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anti-Human LRP1 Anticorps:
anti-Rat (Rattus) LRP1 Anticorps:
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Human Polyclonal LRP1 Primary Antibody pour IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. dans Journal of lipid research 2013
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Human Monoclonal LRP1 Primary Antibody pour ELISA, FACS - ABIN2472827
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. dans Cell and tissue research 1992
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Human Monoclonal LRP1 Primary Antibody pour FACS - ABIN2472830
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. dans Leukemia research 1992
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Dissecting the interaction between TIMP3 (Montrer TIMP3 Anticorps) and LRP1 using a synthetic analog of the LRP1 receptor has been reported.
FVIIa-antithrombin (Montrer SERPINC1 Anticorps) but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin (Montrer SERPINC1 Anticorps) in vivo
Activated alpha2 -Macroglobulin (Montrer A2M Anticorps) Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1
Study demonstrated that LRP1 expression is significantly upregulated by myeloid cells in active multiple sclerosis lesions in comparison to the surrounding healthy tissue. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult.
Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (Montrer CXCL12 Anticorps) antagonize shedding through a TSP-1 (Montrer THBS1 Anticorps)-dependent pathway and ligation of CD28 (Montrer CD28 Anticorps) antagonizes shedding independent of TSP-1 (Montrer THBS1 Anticorps).
Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting
LRP1 single-nucleotide polymorphism is associated with migraine.
Electrostatic potential calculations suggested a competition between negatively charged GAGs and highly negatively charged complement-like domains of LRP-1 for the binding to a positively charged area of TIMP-3 (Montrer TIMP3 Anticorps) as an underlying mechanism.
findings revealed a pH-dependent release of the ligand associated with a conformational change of the receptor. In summary, this investigation of the complete LRP1 ectodomain significantly advances our understanding of this important receptor and provides the basis for further elucidating the mechanism of action of LRP1 in a whole and integrated system.
although fVIII (Montrer F8 Anticorps) bound avidly to soluble forms of clusters II and IV from LRP1, only soluble cluster IV competed with the binding of fVIII (Montrer F8 Anticorps) to full-length LRP1, revealing that cluster IV represents the major fVIII (Montrer F8 Anticorps) binding site in LRP1.
Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE (Montrer APOE Anticorps)). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE (Montrer APOE Anticorps) seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK (Montrer MAPK1 Anticorps) and Akt (Montrer AKT1 Anticorps) activation.
Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli.
both LRP1 and LDLR (Montrer LDLR Anticorps) expression and agLDL uptake are regulated by P2Y2R (Montrer P2RY2 Anticorps) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (Montrer P2RY2 Anticorps) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (Montrer P2RY2 Anticorps) binding to FLN-A (Montrer FLNA Anticorps)
In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (Montrer PRKAA1 Anticorps) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (Montrer MAPK8 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III (Montrer APOC3 Anticorps) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (Montrer LDLR Anticorps)/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK (Montrer MAPK14 Anticorps) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
BMPER (Montrer BMPER Anticorps)/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1