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anti-Human LRP1 Anticorps:
anti-Rat (Rattus) LRP1 Anticorps:
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Human Polyclonal LRP1 Primary Antibody pour IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. dans Journal of lipid research 2013
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Human Monoclonal LRP1 Primary Antibody pour FACS - ABIN2472830
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. dans Cell and tissue research 1992
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Human Monoclonal LRP1 Primary Antibody pour ELISA, FACS - ABIN2472827
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. dans Leukemia research 1992
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LRP1 has a role in insulin (Montrer INS Anticorps) signaling and is a potential role as a link between lipoprotein and glucose metabolism in diabetes [review]
Results indicate that holo-Lf, but not apo (Montrer C9orf3 Anticorps)-Lf, increases TE expression through LRP-1 in human dermal fibroblasts and suggest that holo-Lf and TGF-beta1 (Montrer TGFB1 Anticorps) enhance TE expression by activating the PI3K (Montrer PIK3CA Anticorps)/Akt1 (Montrer AKT1 Anticorps) and PI3K (Montrer PIK3CA Anticorps)/Akt2 (Montrer AKT2 Anticorps) pathways, respectively.
Development of a monoclonal anti-ADAMTS-5 (Montrer ADAMTS5 Anticorps) antibody that specifically blocks the interaction with LRP1.
MMP-13 (Montrer MMP13 Anticorps) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 (Montrer MMP13 Anticorps) and its internalization is independent of the levels of ADAMTS-4 (Montrer ADAMTS4 Anticorps), -5 and TIMP-3 (Montrer TIMP3 Anticorps).
Dissecting the interaction between TIMP3 (Montrer TIMP3 Anticorps) and LRP1 using a synthetic analog of the LRP1 receptor has been reported.
FVIIa-antithrombin (Montrer SERPINC1 Anticorps) but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin (Montrer SERPINC1 Anticorps) in vivo
Activated alpha2 -Macroglobulin (Montrer A2M Anticorps) Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1
Study demonstrated that LRP1 expression is significantly upregulated by myeloid cells in active multiple sclerosis lesions in comparison to the surrounding healthy tissue. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult.
Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (Montrer CXCL12 Anticorps) antagonize shedding through a TSP-1 (Montrer THBS1 Anticorps)-dependent pathway and ligation of CD28 (Montrer CD28 Anticorps) antagonizes shedding independent of TSP-1 (Montrer THBS1 Anticorps).
Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting
MMP-9 (Montrer MMP9 Anticorps) activation by hypoxia requires LRP1 and Pyk2 (Montrer PTK2B Anticorps) phosphorylation in fibroblasts.
Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE (Montrer APOE Anticorps)). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE (Montrer APOE Anticorps) seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK (Montrer MAPK1 Anticorps) and Akt (Montrer AKT1 Anticorps) activation.
Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli.
both LRP1 and LDLR (Montrer LDLR Anticorps) expression and agLDL uptake are regulated by P2Y2R (Montrer P2RY2 Anticorps) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (Montrer P2RY2 Anticorps) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (Montrer P2RY2 Anticorps) binding to FLN-A (Montrer FLNA Anticorps)
In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (Montrer PRKAA1 Anticorps) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (Montrer MAPK8 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III (Montrer APOC3 Anticorps) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (Montrer LDLR Anticorps)/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK (Montrer MAPK14 Anticorps) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1