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The present study shows that sustained activation of P2Y6R may contribute to intestinal tumorigenesis by blocking the apoptotic process and by contributing to chemoresistance, a substantial concern in the treatment of patients with CRC (Montrer CALR Protéines).
UDP/P2Y6 receptor signaling is involved in the regulation of IgE-dependent degranulation in basophils, which might stimulate the P2Y6 receptor via the autocrine secretion of UTP. Thus, this receptor represents a potential target to regulate IgE-dependent degranulation in basophils during allergic diseases.
Expression levels of P2Y6 receptor were higher in Parkinson's disease patients compared to healthy controls.
These data suggest that, without infection, inactivated-H5N1 induces mRNA expression of IL-6 (Montrer IL6 Protéines) and CXCL8 (Montrer IL8 Protéines) by a mechanism, or mechanisms, requiring interaction between viral hemagglutinin (Montrer HA Protéines) and alpha-2,3 sialic acid receptors at the cell membrane of host cells, and involves activation of P2Y6 purinergic receptors.
Rescuing miR (Montrer MLXIP Protéines)-185 expression to inhibit P2Y6 may represent a therapeutic strategy against human aortic vascular smooth muscle cells dysfunction and hypertension.
data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells.
nucleotides released during the airway inflammatory processes will activate P2Y6 receptors, which will lead to further release of inflammatory cytokines.
high millimolar concentrations of ATP increased IL-8 (Montrer IL8 Protéines) and MCP-1 (Montrer CCL2 Protéines) release by the glioma cells stimulated with suboptimal LPS (Montrer IRF6 Protéines) concentration which were blocked by P2X7 (Montrer P2RX7 Protéines) and P2Y6 antagonists
Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA).
Using rat P2Y6 recombinant protein expressed in human astrocytoma cells, the authors found that the P2Y6 receptor is highly selective for UDP over UTP.
Results demonstrated that P2Y6 signaled through Ca(2 (Montrer CA2 Protéines)+) influx and RhoA (Montrer RHOA Protéines)/ROCK to reorganize cytoskeleton and promote migration in myoblasts.
the P2Y6 receptor in the central nervous system, dorsal root ganglion, or both is involved in inhibition of bladder afferent signalling or sensitivity in the pontine micturition centre and that the receptor in the detrusor may be implicated in facilitation to sustain bladder contraction force.
The present study shows that sustained activation of P2Y6R may contribute to intestinal tumorigenesis by blocking the apoptotic process and by contributing to chemoresistance, a substantial concern in the treatment of patients with CRC (Montrer SCRIB Protéines).
P2Y6 contributes to allergic airway inflammation and remodeling by enhancing the functions of mast cells in ovalbumin (Montrer OVA Protéines)-induced asthmatic mice
these findings suggest that the P2Y6 receptor plays a critical role in mediating microglial phagocytosis in radiation-induced brain injury.
P2Y6 UDP receptor, the most expressed P2Y (Montrer P2RY1 Protéines) receptor in mouse resistance arteries, is required for maintaining proper arterial tone.
The present study identifies mouse P2Y6 receptor as a regulator of cardiac development and cardiomyocyte function. P2Y6 receptor could constitute a therapeutic target to regulate cardiac hypertrophy.
These results suggest that increased formation of AT1R (Montrer AGTRAP Protéines)-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II (Montrer AGT Protéines).
Study demonstrates that AgRP (Montrer AGRP Protéines) neurons express the purinergic receptor (Montrer P2RX7 Protéines) 6 (P2Y6), which is activated by uridine-diphosphate (UDP). In vivo, UDP induces ERK (Montrer EPHB2 Protéines) phosphorylation and cFos expression in AgRP (Montrer AGRP Protéines) neurons and promotes action potential firing of these neurons in brain slice recordings.
P2Y (Montrer P2RY1 Protéines)(6) receptor augments pro-inflammatory responses in macrophages
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
G-coupled nucleotide receptor
, P2 purinoceptor
, P2Y purinoceptor 6
, P2Y6 receptor
, P2Y ATP receptor 6
, G protein-coupled P2 receptor
, P2Y purinoceptor 3
, nucleoside diphosphate receptor
, P2Y6 nucleotide receptor
, pyrimidinergic receptor P2Y6