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NKAP is required for T cell maturation and the acquisition of functional competency
NKAP is a novel nuclear regulator of TNF (Montrer TNF Protéines)- and IL-1 (Montrer IL1A Protéines)-induced NF-kappaB (Montrer NFKB1 Protéines) activation
NKAP functions as a transcriptional repressor, acting on Notch (Montrer NOTCH1 Protéines) target genes, and is required for alphabeta T cell development.
NKAP regulates multiple steps in Invariant NKT (Montrer CTSL1 Protéines) cell development and differentiation.
we provide first evidence for the expression of NKAP in neurogenic cells of the adult mammalian brain
Transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development.
Inducible deletion of NKAP in adult mice leads to lethality within 2 weeks, at which point hematopoiesis in the bone marrow has halted and hematopoietic stem cells have disappeared.
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6.
, NF-kappaB activating protein
, NFKB activating protein-like
, chromosome 6 open reading frame 194-like
, nuclear NF-kappaB activating protein
, uncharacterized protein LOC779418
, NFKB activating protein like