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anti-Human SKI Anticorps:
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Human Polyclonal SKI Primary Antibody pour FM, ELISA - ABIN1003140
Li, Turck, Teumer, Stavnezer: Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene. dans Journal of virology 1986
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Human Polyclonal SKI Primary Antibody pour IF, WB - ABIN541156
Derynck, Akhurst, Balmain: TGF-beta signaling in tumor suppression and cancer progression. dans Nature genetics 2001
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Ski is required for the fitness of hematopoietic stem cells , in which it suppresses TGF-beta signaling and abnormal RNA splicing. Active TGF-beta signaling and abnormal RNA splicing occur in a subset of patients with myelodysplastic syndrome who exhibit loss of SKI because of miR-21.
Our work demonstrates for the first time the predominant co-repressive function of SKI in acute myeloid leukemia cells on a genome-wide scale and uncovers the transcription factor RUNX1 as an important mediator of SKI-dependent transcriptional repression.
Findings suggest that c-Ski suppresses transforming growth factor beta (TGF-beta) signaling in clear cell renal carcinoma (ccRCC) cells, which, in turn, attenuates the tumor-suppressive effect of TGF-beta.
The correlation between serum concentrations of IgG4 and SKI methylation levels suggest SKI might be involved in the pathogenesis of autoimmune pancreatitis (AIP).
A microRNA miR-155 regulates transforming growth factor-beta TGF-beta-induced human coronary artery endothelial cells fibrogenic endothelial-mesenchymal transition via the regulator of TGF-beta signaling c-Ski to affect cardiac fibrosis, and miR-155/c-Ski may represent novel biomarkers and therapeutic targets for cardiac fibrosis.
Study identified Ski as a functional tumor suppressor with frequent epigenetic inactivation in lung cancer.
Transforming Growth Factor beta inhibitor peptide P144 downregulates SKI and an upregulates SMAD7 at both transcriptional and translational levels in glioblastoma cell lines.
miR-1908 had a positive role in scar formation by suppressing Ski-mediated inflammation and fibroblast proliferation in vitro and in vivo.
Overexpression of Ski wild type, but not S326D and S383D mutants inhibited centrosome amplification and cellular transformation induced by AURKA.
our findings suggest that Ski represses TGF-b-induced EMT and invasion by inhibiting SMAD-dependent signaling in non-small cell lung cancer
Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.
Eight recurrent and three novel SKI mutations from eleven SGS patients were located in the R-SMAD binding domain, except for one in the DHD domain.
acetaldehyde up-regulates COL1A2 by modulating the role of Ski and the expression of SMADs 3, 4, and 7.
c-Ski is an important regulator in the activation of CAFs and may serve as a potential therapeutic target to block breast cancer progression.
Ski expression is a novel negative feedback mechanism acting on retinoic acid signaling
Overall, these studies demonstrate altered Ski protein levels, degradation and localization in human papillomavirus16-transformed human keratinocytes and in cervical cancer.
The 1p36.33-1p36.32 deletion encompassing SKI may represents a previous undescribed microdeletion disorder.
Transgenic K562 cells have distinct gene expression profiles both in steady state and during terminal erythroid differentiation, with GATA1s expression characterised by lack of repression of MYB, CCND2 and SKI.
The study data provide limited support for the hypothesis that common SKI variants are susceptibility factors for non-syndromic cleft lip/palate.
We identified causative variation in ten individuals with SGS in the proto-oncogene SKI, a known repressor of TGF-beta activity.
study reveals a critical mechanism by which TGFbeta controls TH17 cell differentiation and uncovers the SKI-SMAD4 axis as a potential therapeutic target for treating TH17-related diseases
our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease.
Trnsgenic mice overexpressing chicken Ski (c-Ski) have marked decrease in adipose mass with skeletal muscle hypertrophy Results suggest Ski plays a major role in skeletal muscle metabolism and adipogenesis and hence influences risk of obesity and diabetes
After Qingyi Huaji treatment, Ski expression was reduced and pancreatic tumor growth slowed down significantly.
Satb2 recruits Ski to the Ctip2 locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex.
Data on expression of Ski suggest that Ski is involved in follicular development, oogenesis, ovulation, and luteinization. During the estrous cycle, Ski expression was apparent at proestrus and estrus, faint at metestrus, highest at diestrus.
The presented data support a new role for Ski in the mitotic process and in maintenance of genetic stability
Ski regulates several genetic programs and signalling pathways that regulate skeletal muscle and adipose mass to influence body composition development, suggesting that Ski may have a role in risk for obesity and metabolic disease.
Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice
SnoN and Ski proteins are up-regulated during liver regeneration
c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity
Ski corepressor binds to Gli3 and recruits the histone deacetylase complex.Furthermore, a Ski mutation enhanced the digit abnormalities caused by the Gli3 gene mutation.
The protein degradation rate is significantly reduced in the fast twitch muscles of c-ski transgenic animals with respect to controls
c-ski hyperexpression prevents Lewis lung carcinoma-induced muscle wasting in the extensor digitorum longus muscle
The results show that normal ocular development requires the function of the Ski proto-oncogene, and mice lacking Ski have many features associated with PHPV(persistent hyperplastic primary vitreous), and some similarities with Peters anomaly in humans.
c-Ski induces myogenic differentiation through acting on MyoD and inhibiting HDAC activity in the nucleus of myogenic cells.
These results suggest that Arkadia targets Ski-bound, inactive phospho-Smad2/3 to regulate positively Myostatin/TGF-beta signaling.
Ski is necessary for muscle terminal differentiation and that it exerts this role, at least in part, through its association with Six1 and Eya3 to regulate the Myog transcription
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation.
, ski oncogene
, ski oncoprotein
, v-ski sarcoma viral oncogene homolog (avian)
, avian sarcoma viral (v-ski) oncogene homolog natural resistance-associated macrophage protein 1
, v-ski avian sarcoma viral oncogene-like protein
, Sloan-Kettering viral oncogene homolog
, ski sarcoma viral oncogene homolog
, v-ski sarcoma viral oncogene homolog
, nuclear oncoprotein skia