Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
Tal1 plays an essential role in regulating neurotransmitter phenotype in the developing thalamic nuclei.
Genome-wide analysis indicated that LMO2 (Montrer LMO2 Protéines) is required at the hemangioblast stage to position the TAL1/LMO2 (Montrer LMO2 Protéines)/LDB1 (Montrer LDB1 Protéines) complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
TAL1 and GATA1 (Montrer GATA1 Protéines) form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations
SCL-LMO1 (Montrer LMO1 Protéines) upregulated a stem cell gene signature in DN3 thymocytes.
TAL1 binds specifically to many genomic locations in multilineage precursor and erythroid progenitor cells, before GATA1 (Montrer GATA1 Protéines) is produced abundantly.
Ectopic Runx1 (Montrer RUNX1 Protéines) expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
Tal1 has a role in severe renal disease and patchy alopecia in Hairpatches (Hpt) mice
Only Scl but not Map17 (Montrer PDZK1IP1 Protéines) could rescue the Scl(Delta40/Delta40) ES phenotype.
Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch (Montrer NOTCH1 Protéines) pathways during the embryonic endothelial-to-hematopoietic transition.
a novel role for GATA-4 (Montrer GATA4 Protéines) and TAL1 to affect skeletal myogenic differentiation and EPO (Montrer EPO Protéines) response via cross-talk with Sirt1 (Montrer SIRT1 Protéines).
HOPX (Montrer HOPX Protéines) is functionally regulated by SCL (Montrer KRT7 Protéines) in hematoendothelial differentiation of mesoderm progenitor cells.
NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR
mutations of SF3B1 (Montrer SF3B2 Protéines) may block erythropoiesis via dysregulation of alternative RNA splicing of transcription factor TAL1
a novel role of FOXP3 (Montrer FOXP3 Protéines) as a tumor suppressor in T-ALL through modulation of TAL1 transcriptional activity.
Review emphasizes recent findings that shed light into the intricacies of TAL1 (epi (Montrer TFPI Protéines))genetic regulation and the transcription network orchestrated by this major T-cell oncogene (Montrer RAB1A Protéines).[reiew]
Deletions of TAL1 is associated with acute T-lymphoblastic leukemia.
SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis.
Upregulation of TAL1 is associated with T-cell acute lymphoblastic leukemia.
Concurrent exogenous expression of three transcription factors, GATA1 (Montrer GATA1 Protéines), FLI1 (Montrer FLI1 Protéines) and TAL1, enables large-scale production of megakaryocytes from human pluripotent stem cells.
analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter
The latter data suggest that Stil play a role in retina cell proliferation through the Shh (Montrer SHH Protéines) signal transduction pathway.
Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions.
Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC (Montrer FUT1 Protéines) development.
Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation
Ets1-related protein (Montrer ETV2 Protéines) plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2 (Montrer LMO2 Protéines)-induced haemangioblasts differentiate into endothelial cells
Zebrafish scl has a role in hematopoietic and endothelial development, downstream of hemangioblast development.
scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium
Scl participates in multiple processes requiring different levels and functions
While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification.
Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.
T-cell acute lymphocytic leukemia 1
, T-cell acute lymphocytic leukemia protein 1 homolog
, stem cell protein
, T-cell acute lymphocytic leukemia protein 1
, T-cell leukemia/lymphoma protein 5
, class A basic helix-loop-helix protein 17
, tal-1 product
, stem cell leukaemia
, stem cell leukemia protein SCL
, Avian SCL
, stem-cell leukemia hematopoietic transcription factor
, transcription factor