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Human Polyclonal ZCCHC11 Primary Antibody pour IHC (p), IHC - ABIN256311
Piskounova, Polytarchou, Thornton, LaPierre, Pothoulakis, Hagan, Iliopoulos, Gregory: Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. dans Cell 2011
Show all 2 Pubmed References
Mouse (Murine) Polyclonal ZCCHC11 Primary Antibody pour ELISA, WB - ABIN4366734
Minoda, Saeki, Aki, Takaki, Sanada, Koga, Kobayashi, Takaesu, Yoshimura: A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. dans Biochemical and biophysical research communications 2006
The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU).
For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA (Montrer DROSHA Anticorps) rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 (Montrer ESR1 Anticorps) rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR (Montrer MLXIP Anticorps)-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s
Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase (Montrer TUT1 Anticorps)) Zcchc11 (TUT4) activity.
Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.
miR (Montrer MLXIP Anticorps)-26a directly targets Lin28B (Montrer LIN28B Anticorps) and Zcchc11-two critical repressors of let-7 maturation.
Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
Lin28 (Montrer LIN28A Anticorps) uses two different TUTases to control let-7 expression .
Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity
TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer (Montrer DICER1 Anticorps) processing. Knockdown of TUT4 and Lin28 (Montrer LIN28A Anticorps) reduces the level of stem cell markers
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (Montrer IL22 Anticorps) after LPS (Montrer IRF6 Anticorps) treatment and suppresses the TRAF6 (Montrer TRAF6 Anticorps)-dependent activation of NF-kappaB (Montrer NFKB1 Anticorps).
We conclude that the Zcchc11-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF-1 (Montrer IGF1 Anticorps) expression and enhancing postnatal growth and survival
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (Montrer TIFA Anticorps) after LPS (Montrer TLR4 Anticorps) treatment and suppresses the TRAF6 (Montrer TRAF6 Anticorps)-dependent activation of NF-kappaB (Montrer NFKB1 Anticorps).
Zcchc11 fine tunes IL-6 (Montrer IL6 Anticorps) production by uridylating miR (Montrer MLXIP Anticorps)-26a.
Lin28 (Montrer LIN28A Anticorps) recruits the TUTase (Montrer TUT1 Anticorps) Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
ZCCHC11 is an RNA uridyltransferase (EC 188.8.131.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009
PAP associated domain containing 3
, TUTase 4
, terminal uridylyltransferase 4
, zinc finger CCHC domain-containing protein 11
, zinc finger, CCHC domain containing 11
, Caffeine Induced Death (S. pombe Cid) homolog family member (cid-1)-like
, terminal uridylyltransferase 4-like