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anti-Human ZFP36L2 Anticorps:
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Cow (Bovine) Polyclonal ZFP36L2 Primary Antibody pour WB - ABIN2780810
Hudson, Martinez-Yamout, Dyson, Wright: Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. dans Nature structural & molecular biology 2004
Significantly mutated gene ZFP36L2 displayed strong antiproliferation function in Esophageal Squamous Cell Carcinoma but not in Esophageal Adenocarcinomas.
silencing ZFP36L2 inhibited cancer cell aggressiveness in pancreatic ductal adenocarcinoma cell lines, and overexpression of ZFP36L2 was confirmed in pancreatic ductal adenocarcinoma clinical specimens
Study of the role of the C-terminal residues in the structure of unbound TIS11d, the E220A mutant and the truncation mutant lacking the last two residues (D219/E220) using molecular dynamics, NMR spectroscopy, and biochemical methods
The roles of TTP and BRF proteins in regulated mRNA decay.
Data suggest that the dysregulation of TIS11D function is associated with the pathogenesis of certain types of leukemia.
ZFP36L2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
Multiple nanosecond timescale molecular dynamics trajectories of TIS11d wild-type and E157R/E195K mutant with different RNA sequences were performed to investigate the molecular basis for RNA binding specificities of this TZF domain.
polymorphisms sequenced in genomic DNA encoding the TTP protein (ZFP36) and those of its two known mammalian relatives, ZFP36L1 and ZFP36L2, from 72 to 92 anonymous human subjects from various geographical and ethnic backgrounds
Sequence specificity in RNA recognition is achieved by a network of intermolecular hydrogen bonds, mostly between TIS11d main-chain functional groups and the Watson-Crick edges of the bases
These data suggest TIS11D as a candidate p53 target gene that may be part of the network of genes responsible for p53-dependent apoptosis.
Loss of ZFP36L2 is associated with female infertility.
The Zfp36l2 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 signaling with DNA damage and cell cycle control.
Study tested for the first time a role of ZFP36L2 in the decay of LHR mRNA, when transcription was inhibited; results of our cell-based assay support the conclusion that LHR mRNA expression is controlled post-transcriptionally by ZFP36L2.
ZFP36L1 and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle.
In mature peripheral neurons, ZFP36L2 mediates post-transcriptional mechanisms by promoting axonal integrity.
lack of the physiological down regulation of luteinizing hormone receptor mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest
ZFP36L2 therefore functions as part of a molecular switch promoting BFU-E self-renewal and a subsequent increase in the total numbers of colony-forming unit-erythroid (CFU-E) progenitors and erythroid cells that are generated
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
ZFP36L2 has a critical role in lymphocyte development and may function as a tumor suppressor.
model of disruption of the earliest stages of embryogenesis, implicating Zfp36l2, a probable mRNA-binding and destabilizing protein, in the physiological control of female fertility at the level of early embryonic development
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.
EGF-response factor 2
, ZFP36-like 2
, butyrate response factor 2
, zinc finger protein 36, C3H type-like 1
, zinc finger protein 36, C3H type-like 2
, zinc finger protein 36, C3H1 type-like 2
, zinc finger protein, C3H type, 36-like 2
, zinc finger protein 36, C3H type-like 2-like
, CCCH zinc finger protein 3-B
, CCCH zinc finger protein C3H-3
, zinc finger protein 36, C3H1 type-like 2-B
, LOW QUALITY PROTEIN: zinc finger protein 36, C3H1 type-like 2
, mRNA decay activator protein ZFP36L2