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17betaHSD7 is not the key enzyme responsible for androstenone and testosterone metabolism in porcine liver cells
New insights to the transcriptional regulation of 3betaHSD1 and 17betaHSD7 and further hints to their involvement in steroid metabolism.
Substrate affinity of 17beta-hydroxysteroid dehydrogenase type 7 toward estrone and 5alpha-dihydrotestosterone are similar.
Inhibition of 17beta-HSD 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Substrate inhibition of 17beta-HSD1 in tumor epithelial cells and regulation of 17beta-HSD7 by 17beta-HSD1 knockdown has been demonstrated.
the dual functional 17beta-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of estradiol and dihydrotestosterone.
17beta-HSD1 and 17beta-HSD7 are principal reductive 17beta-hydroxysteroid dehydrogenases and major players in the viability of estrogen-dependent breast cancer cells.
The transcriptional activity of the HSD17B7 gene containing the G allele is higher than that of the C allele. This difference in HSD17B7 expression may regulate the risk of peripheral edema as an adverse reaction induced by estramustine phosphate sodium
Data show that apicidin significantly lowers HSD17B1 transcript and protein levels in endometrial adenocarcinoma cells, with no significant effect on HSD17B1 transcript stability.
estradiol stimulates HSD17B7 transcriptional activity in breast cancer cells through a novel mechanism requiring NF1 and strongly suggest a positive feedback mechanism, increasing estradiol synthesis causing growth of estrogen-dependent breast cancers
increased expression of HSD17B7 is associated with breast cancer.
HSD17B7 is a novel candidate for inborn errors of cholesterol metabolism
Comparison of the promoter region of the human and murine gene.
The identified proximal promoter regions of both human and murine HSD17B7 genes contain multiple transcription factor binding sites and show strong similarity to cholesterogenic genes.
Results provide unequivocal evidence for a role of 17beta-hydroxysteroid dehydrogenase type-7 in cholesterol biosynthesis.
17beta-hydroxysteroid dehydrogenase type 7(17beta-HSD type 7)was significantly upregulated in ovarian tissue of patients with ovarian endometriosis.
17-beta hydroxysteroid dehydrogenase type 7 (HSD17B7) -shRNA sequences were designed and tested for their effectiveness.
determined the activity and expression levels of known estrogenic 17beta-HSDs, namely types 1, 7 and 12 17beta-HSD in preadipocytes before and after differentiation into mature adipocytes
There is no difference in catalytic properties between variants of 17beta-HSD types 7 and 12 and wild-type enzymes, while variants p.Glu77Gly and p.Lys183Arg in 17beta-HSD type 5 showed a slightly decreased activity.
a recessive mutation, rudolph, that causes abnormal forebrain development was identified in hydroxysteroid (17-beta) dehydrogenase 7 gene, an enzyme necessary for cholesterol biosynthesis.
Hsd17b7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos
Data show that prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 plays an important role in fetal survival and embryonic development in mice.
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 18.104.22.168) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 22.214.171.1240) in the biosynthesis of cholesterol (Marijanovic et al., 2003
, 17-beta hydroxysteroid dehydrogenase
, hydroxysteroid (17-beta) dehydrogenase 7
, 17-beta-hydroxysteroid dehydrogenase type 7
, 3-keto-steroid reductase-like
, 17 beta-hydroxysteroid dehydrogenase type VII
, 17-beta-HSD 7
, 17-beta-hydroxysteroid dehydrogenase 7
, 17beta hydroxysteroid dehydrogenase
, estradiol 17-beta-dehydrogenase 7
, short chain dehydrogenase/reductase family 37C, member 1
, PRL receptor-associated protein
, hydroxysteroid dehydrogenase 17 beta, type 7