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anti-Mouse (Murine) Ankyrin G Anticorps:
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Mammalian Monoclonal Ankyrin G Primary Antibody pour ISt, IHC - ABIN1304536
Komulainen, Zdrojewska, Freemantle, Mohammad, Kulesskaya, Deshpande, Marchisella, Mysore, Hollos, Michelsen, Mågard, Rauvala, James, Coffey: JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination. dans Frontiers in cellular neuroscience 2014
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Mammalian Monoclonal Ankyrin G Primary Antibody pour ISt, IHC - ABIN1304537
Winterflood, Platonova, Albrecht, Ewers: Dual-Color 3D Superresolution Microscopy by Combined Spectral-Demixing and Biplane Imaging. dans Biophysical journal 2015
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Mammalian Monoclonal Ankyrin G Primary Antibody pour ISt, IHC - ABIN1304534
Yamankurt, Wu, McCarthy, Cunha: Exon organization and novel alternative splicing of Ank3 in mouse heart. dans PLoS ONE 2015
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Our data suggest that alterations of Ank3 expression and function may contribute to the effects of ELS on the development of psychiatric disorders.
Studied effect of reduced expression of the large isoforms of Ank3 on cognition and behavior using a heterozygous knockout mouse model; found evidence for increased anxiety and observed specific neuroanatomical defects in heterozygous knockout mice, including a smaller cingulate cortex, granular retrosplenial cortex, primary motor cortex and fimbria of the hippocampus.
Interaction of Ankyrin-G with EB1 (Montrer MAPRE1 Anticorps) protein drives axon initial segment formation and neuronal polarity.
Ank3 is subject to complex alternative splicing regulation resulting in a diverse population of ankyrin-G isoforms in heart.
This study found that ankyrin-G regulates canonical Wnt (Montrer WNT2 Anticorps) signaling by altering the subcellular localization and availability of beta-catenin (Montrer CTNNB1 Anticorps) in proliferating cells.
The data support a model where ankyrinG-binding is required for preferential Nav1.6 (Montrer SCN8A Anticorps) insertion into the axon initial segment plasma membrane during development.
CK2 (Montrer CSNK2A1 Anticorps)-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance.
the structures of ANK (Montrer ANKH Anticorps) repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 (Montrer SCN2A Anticorps) peptide, are reported.
The giant exon of AnkG is required for assembly of the AIS (Montrer AR Anticorps) and nodes of Ranvier and was a transformative innovation in evolution of the vertebrate nervous system that now is a potential target in neurodevelopmental disorders.
giant ankyrin-G promotes GABAergic synapse stability through opposing endocytosis of GABAA (Montrer GABRg1 Anticorps) receptors, and requires a newly described interaction with GABARAP (Montrer GABARAP Anticorps), a GABAA receptor-associated protein (Montrer GABARAP Anticorps).
In embryonic mouse axons, AnkG is expressed at the beginning of axonogenesis at E9.5 and initially distributed homogeneously along the entire growing axon. From E11.5 the protein progressively becomes restricted to the proximal axon.
an association between ANK3 rs10994336, rs10994338, rs4948418 and rs958852 and schizophrenia risk in a northern Chinese Han population.
The combination of tract-based spatial statistics (TBSS) with genotyping can be powerful to unveil the role of white matter in bipolar disorder, in conjunction with risk genes, ANK3 and ZNF804A.
A significant association was found between bipolar disorder and rs10994336 (OR=1.18; 95% confidence interval: 1.06-1.31; P=0.0027) as well as rs1938526 (OR=1.16; 95% confidence interval: 1.06-1.28; P=0.0016) in ANK3.
Thus ANK3's important association with human bipolar susceptibility may arise from imbalance between AnkG function in interneurons and principal cells and resultant excessive circuit sensitivity and output.
ANK3 expression is associated with androgen receptor (Montrer AR Anticorps) stability, invasiveness, and lethal outcome in prostate cancer patients.
Nonsense mutation in ANK3 was identified in a patient with speech impairment, intellectual disability and autistic features.
Decreases in UF FA were observed among BD subjects carrying the ANK3 rs9804190 risk allele (T), compared to CC and T-carrier control subjects and BD CC homozygotes.
This study identified a SNP in ANK3 with a strong protective effect for Bipolar Disorder and Schizophrenia.
The haplotype analysis results suggest that ANK3 variants rs1938526 and rs10994336 may confer susceptibility for BD in the Korean population. Association analysis revealed a probable genetic difference between Korean and Caucasian populations in the degree of ANK3 involvement in BD pathogenesis.
The ankyrin 3 genotype may be associated with pathogenesis of age-related neurodegeneration, and, in part, of bipolar disorder.
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats\; a central region with a highly conserved spectrin binding domain\; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.
, ankyrin 3, node of Ranvier (ankyrin G)
, ankyrin 3, node of Ranvier (ankyrin G)-like
, brain-specific ankyrin-G
, ankyrin G119