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Human CX3CL1 Protein expressed in Escherichia coli (E. coli) - ABIN803628
Yoong, Too: Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Show all 2 Pubmed References
Human CX3CL1 Protein expressed in Human Cells - ABIN2003167
Bazan, Bacon, Hardiman, Wang, Soo, Rossi, Greaves, Zlotnik, Schall: A new class of membrane-bound chemokine with a CX3C motif. dans Nature 1997
Show all 3 Pubmed References
Human CX3CL1 Protein expressed in - ABIN621641
Kim, Rooper, Xie, Kajdacsy-Balla, Barbolina: Fractalkine receptor CX(3)CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells. dans Molecular cancer research : MCR 2012
The chemokine (Montrer CCL1 Protéines) CX3CL1 was established as a central NF-kappaB (Montrer NFKB1 Protéines) target gene mediating therapy resistance. While no direct impact of CX3CL1 expression on cancer cell apoptosis was identified in co-culture assays it became apparent that CX3CL1 is acting in a paracrine fashion, leading to an increased recruitment of inflammatory cells.
TRAF1 (Montrer TRAF1 Protéines), CTGF (Montrer CTGF Protéines), and CX3CL1 genes are hypomethylated in osteoarthritis
Low shear stress ( approximately 4.58 dyne/cm) for more than 1 h promoted Fractalkine expression and activated the extracellular signal-regulated kinase (ERK)1 (Montrer MAPK3 Protéines)/2, p38 (Montrer CRK Protéines), and Jun N-terminal kinase (JNK (Montrer MAPK8 Protéines)) mitogen-activated protein kinases signaling pathways by their phosphorylation.
The results strongly suggest that glutaminyl cyclase (Montrer QPCT Protéines)-catalysed N-terminal pyroglutamate formation of CX3CL1 is important for the stability or the interaction with its receptor and opens new insights into the function of glutaminyl cyclase (Montrer QPCT Protéines) in inflammation.
Serum fractalkine levels were significantly higher in the impaired glucose tolerance and type 2 diabetes groups compared to the normal glucose tolerance group.
Reduced fractalkine levels were found in follicular fluid and granulosa cells, accompanied by decreased progesterone production and reduced steroidogenic acute regulatory protein (Montrer STAR Protéines) (StAR) expression in the granulosa cells of patients with polycystic ovary syndrome. Administration of fractalkine reversed the inhibition of progesterone and StAR expression.
The US28 gene product has maintained the function of the ancestral gene and has the ability to bind and signal in response to human CX3CL1, the natural ligand for CX3CR1 (Montrer CX3CR1 Protéines).
we conclude that fractalkine may be involved in vulnerability of human carotid plaque
CX3CL1/CX3CR1 (Montrer CX3CR1 Protéines) axis plays a key role in the development of ischemia-induced oligodendrocyte injury via p38MAPK (Montrer MAPK14 Protéines) signaling pathway.
miR (Montrer MLXIP Protéines)-223 controls the expression of CX3CL1 by targeting HDAC2 (Montrer HDAC2 Protéines) in chronic obstructive pulmonary disease patients and mouse models of the disease.
the CX3CL1/CX3CR1 (Montrer CX3CR1 Protéines) axis contributes to the proliferative and pro-inflammatory effects of Ang II (Montrer AGT Protéines) in VSMCs.
that CX3CL1-CX3CR1 (Montrer CX3CR1 Protéines) signaling is a molecular mechanism capable of modulating microglial-mediated degeneration
CXCR4 (Montrer CXCR4 Protéines)(+) CD45 (Montrer PTPRC Protéines)(-) bone marrow cells are niche forming for osteoclastogenesis via the SDF-1 (Montrer CXCL12 Protéines), CXCL7 (Montrer PPBP Protéines), and CX3CL1 signaling pathways in bone marrow.
Increased fractalkine and its receptor CX3CR1 (Montrer CX3CR1 Protéines) may cause a cross-talk between activated glial cells and neurons, playing an important role in the development of neuroinflammation in fructose-fed mice.
in this study, CX3CL1 is identified as a novel substrate of MMP-19 (Montrer MMP19 Protéines)
The CX3CL1/CX3CR1 (Montrer CX3CR1 Protéines) system is essential for restricting coxsackievirus B3-induced myocarditis.
changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine (Montrer CCL1 Protéines) involved in the immune response that has been linked to AD and to other different neurological disorders.
the individual and combined actions of CCL2 (Montrer CCL2 Protéines)/CCR2 (Montrer CCR2 Protéines) and CX3CL1/CX3CR1 (Montrer CX3CR1 Protéines) in hypoxia-induced pulmonary hypertension in mice, is reported.
Medial ganglionic eminence (MGE) interneurons secrete fractalkine that promotes genesis of oligodendrocytes from glially biased cortical precursors in culture. Moreover, when MGE interneurons are genetically ablated in vivo prior to their migration, this causes a deficit in cortical oligodendrogenesis.
Chemotactic factor. Binds to CX3CR1.
, chemokine (C-X3-C motif) ligand 1
, CX3CL1 chemokine
, C-X3-C motif chemokine 1
, CX3C membrane-anchored chemokine
, small inducible cytokine subfamily D, 1
, small-inducible cytokine D1
, small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
, small inducible cytokine subfamily D (Cys-X3-Cys), member-1