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anti-Rat (Rattus) GABRA6 Anticorps:
anti-Human GABRA6 Anticorps:
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Mouse (Murine) Polyclonal GABRA6 Primary Antibody pour WB - ABIN550208
McKernan, Rosahl, Reynolds, Sur, Wafford, Atack, Farrar, Myers, Cook, Ferris, Garrett, Bristow, Marshall, Macaulay, Brown, Howell, Moore, Carling, Street, Castro, Ragan, Dawson, Whiting: Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. dans Nature neuroscience 2000
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Mouse (Murine) Polyclonal GABRA6 Primary Antibody pour ICC, IF - ABIN152537
Nusser, Ahmad, Tretter, Fuchs, Wisden, Sieghart, Somogyi: Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene. dans The European journal of neuroscience 1999
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Rat (Rattus) Polyclonal GABRA6 Primary Antibody pour IHC, WB - ABIN1742463
Joensuu, Tegelberg, Reinmaa, Segerstråle, Hakala, Pehkonen, Korpi, Tyynelä, Taira, Hovatta, Kopra, Lehesjoki: Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation. dans PLoS ONE 2014
Mouse (Murine) Polyclonal GABRA6 Primary Antibody pour IHC, WB - ABIN152496
Brandon, Delmas, Kittler, McDonald, Sieghart, Brown, Smart, Moss: GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. dans The Journal of biological chemistry 2001
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Cow (Bovine) Polyclonal GABRA6 Primary Antibody pour ELISA, WB - ABIN4273248
Green, Grozeva, Moskvina, Hamshere, Jones, Jones, Forty, Caesar, Gordon-Smith, Fraser, Russell, St Clair, Young, Ferrier, Farmer, McGuffin, Holmans, Owen, ODonovan, Craddock: Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. dans American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010
stress-associated suicide risk is elevated in carriers of the GABRA6 rs3219151 T allele with several independent markers and predictors of suicidal behaviours converging to this increased risk.
TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals
NOS3, GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity.
The gene-gene interaction at two loci involving GABRA6 and Synapsin II revealed a significant association for development of idiopathic generalized epilepsy.
genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA.
GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression
Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability.
significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population
studies have found prefrontal cortical GABA(A) receptor alpha subunit alterations in schizophrenia
These findings suggest that common variation in the GABRA2, GABRA3, GABRA6, and GABRG2 genes does not play a major role in liability to anxiety spectrum disorders.
These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits.
alpha1 and alpha6 subunits immobilize recombinant GABA A receptor in transfected cells
The T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress.
GABRA6 expression is regulated by NFI in cerebellar granule neurons
Findings support a role for GABRA6 (Pro385Ser) in perceived parenting.
polymorphisms of the GABAA alpha1 and GABAA alpha6 receptor gene may be associated with the development of alcoholism and the GG genotype of the GABAA alpha1 receptor may cause early onset and a severe type of alcoholism
Polymorphism not associated with panic disorder.
Chinese patients with certain psychiatric characteristics and GABRA6 heterozygosity are probably predisposed to functional heartburn
The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence.
Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism.
The GABRA6 SNP rs3219151 has been significantly associated with alcohol dependence in studies on the Taiwanese Han, Korean, Finnish and South-western Native American populations.
D3R modulates GABAA receptors function in striatum: chronic blockade of D3R increases alpha6 subunit expression and induces insensitivity to the anxiolytic effect of diazepam
This study demonstrated that Ectopic Expression of alpha6 GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
results indicate that in addition to the central role of homologous gamma-aminobutyric acid (GABA) A receptor subunit alpha 6-100R/Q (alpha1-101H) residue in benzodiazepine(BZ) binding this critical BZ binding site has a major impact on BZ binding kinetics
Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling.
ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition
Abnormal cerebellar P/Q-type VGCC activity results in a deficit of CGC-specific subtype(s) of GABA(A) receptors which may contribute to, or may be a consequence of the impaired cerebellar network signaling that occurs in cacna1a(tg) mice.
some aspects of assembly, trafficking, targeting, and/or expression of extrasynaptic alpha6-containing GABA(A) receptors in cerebellar granule cells are selectively regulated by AMPA receptor-mediated signaling
These findings suggest that the higher CNS depressant level achieved by ketamine may be the result of its selective actions on alpha6beta2/3delta receptors.
We tested the hypothesis that homocysteine (Hcy) antagonizes the GABA(A) receptor and behaves as an excitotoxic neurotransmitter that causes blood brain barrier (BBB) permeability and vascular dementia.
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
GABA(A) receptor subunit alpha-6
, GABA-A receptor alpha-6 subunit
, gamma-aminobutyric acid A receptor, alpha 6
, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6
, gamma-aminobutyric acid A receptor, alpha 6
, gamma-aminobutyric acid receptor subunit alpha-6
, GABA subunit A receptor alpha 6
, GABA(A) receptor, alpha 6
, gamma-aminobutyric acid (GABA) A receptor, alpha 6
, gamma-aminobutyric acid receptor subunit alpha-6-like
, gamma-aminobutyric acid A recptor, subunit alpha 6
, subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor
, GABA-A receptor a6 subunit