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Human Polyclonal RIMS1 Primary Antibody pour ICC, IHC - ABIN1742305
Bello, Zanetti, Mayorga, Michaut: RIM, Munc13, and Rab3A interplay in acrosomal exocytosis. dans Experimental cell research 2012
Show all 11 Pubmed References
Rat (Rattus) Polyclonal RIMS1 Primary Antibody pour ICC, IHC - ABIN1742306
Limbach, Laue, Wang, Hu, Thiede, Hultqvist, Kilimann: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site. dans Proceedings of the National Academy of Sciences of the United States of America 2011
This is the first reported case of bilateral cystoid macular edema in association with the RIM1 mutation. Overall, our findings were more consistent with a phenotype of retinitis pigmentosa.
The study identified a region on chromosome 6 comprising the genes SMAP1, B3GAT2, and RIMS1 as novel susceptibility locus for pediatric venous thromboembolism.
Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
a novel functional coupling between RIM1 and the L-type Ca(V) channels via the Ca(V)beta auxiliary subunit that contribute to determine insulin secretion.
Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.
Rim1 is a component of the presynaptic active zone and modulator of exocytosis and binds 14-3-3 through its N terminus
Even though the absence of pathogenic mutations suggests that RIM1 is notinvolved in autosomal recessive retinitis pigmentosa.
A possible role for RIMS1 in the enhancement of cognitive function at least in this kindred is suggested.
The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene.
regulating synaptic membrane exocytosis 1
, regulating synaptic membrane exocytosis protein 1-like
, regulating synaptic membrane exocytosis protein 1
, RIM 1
, Rab3 effector
, Rab3 interacting protein 1
, rab-3-interacting molecule 1
, rab-3-interacting protein 1
, rab3-interacting molecule 1
, rab3-interacting protein 1
, synaptic exocytosis regulator 1
, RAB3-interacting protein 2
, rab-3-interacting protein 2
, Rim1b protein