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the overall architecture of Dare-C1qAgD is similar to human C1qA, residues involved in C1qBgD, C1qCgD, and CRP (Montrer CRP Protéines) binding are somewhat different while residues involved in IgG binding are not present in zebrafish. The structure gives insight into how human and fish C1qA evolved from an ancestral protein
C1qA globular domain (C1qAgD) was expressed, purified and crystallized.
We, for the first time, identified the associations between C1q gene SNPs and autoimmune thyroid diseases, and our findings suggested that five common SNPs in C1q gene were not associated with autoimmune thyroid diseases susceptibility in Chinese Han population
exposure of neural stem cells to neutrophil-synthesized concentrations of C1q and C3a (Montrer C3 Protéines) promoted astrogliogenesis and cell migration
this studies show binding of VWF (Montrer VWF Protéines) to C1q and thus a direct interaction between starter molecules of hemostasis and the classical pathway of complement
Cerebrospinal fluid (CSF (Montrer CSF2 Protéines)) soluble complement receptor 2 (sCR2 (Montrer RBMS1 Protéines)) levels correlated significantly both with CSF (Montrer CSF2 Protéines) complements C3 and C1q as well as to a disease severity measure.
This study reveled that C1QA having a central role in the bipolar disease and schizophrenia manifestation.
no significant association found to either rs15940 (C1QA) or rs172378 (C1QC (Montrer C1QC Protéines)) when analysed in just Parkinson disease cases , just controls or combined
Our findings showed that Brugia malayi Calreticulin (Montrer CALR Protéines) (BmCRT) is responsible for the prevention of classical complement pathway activation via its interaction with the first component C1q of the human host
interaction with calreticulin (Montrer CALR Protéines) controls the phagocyte inflammatory status
A newly characterized leech calreticulin (Montrer CALR Protéines) (HmCalR) has been shown to interact with C1q and participate to the HmC1q-dependent microglia accumulation.
findings show that C1q rather than FcgammaRs controls the Ab-mediated Ag uptake and its presentation by spleen APC (Montrer APC Protéines) subsets to T cells
Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (Montrer PTPRC Protéines)-positive cells in kidney fibrosis.
Deleting C1qa gene significantly reduces synaptic pruning by Grn (Montrer GRN Protéines)(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn (Montrer GRN Protéines)(-/-) mice; results uncover a previously unrecognized role of progranulin (Montrer GRN Protéines) in suppressing aberrant microglia activation during aging.
developmental mechanisms of C1qa may be re-engaged during injury response
C1q is involved in the pristane-mediated enhanced inflammatory response to TLR7 (Montrer TLR7 Protéines) stimulation.
Data (including data from studies in mutant mice) suggest exercise prevents age-related neurovascular decline, up-regulation of C1qa, and down-regulation of astrocytic Apoe (Montrer APOE Protéines); this preventive effect of exercise does not occur in Apoe (Montrer APOE Protéines)-deficient mice.
critical role in activation of beta-catenin (Montrer CTNNB1 Protéines) signalling in hypertensive arterial remodelling
Data (including data on knockout mice) suggest, in absence of Trem2 (triggering receptor expressed on myeloid cells 2 (Montrer TREM2 Protéines)), pulmonary macrophages selectively produce elevated levels of C1q resulting in enhanced phagocytosis during pneumococcal pneumonia.
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.
complement component 1, q subcomponent, alpha polypeptide
, complement C1q subcomponent subunit A
, complement component 1, q subcomponent, A chain
, complement component C1q, A chain
, complement C1qA