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Stewart, Nijmeh, Brightling, Sayers: uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium. dans Thorax 2012
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Human PLG Kit ELISA pour Sandwich ELISA - ABIN780340
Andersen, Friis, Hansen, Svenningsen, Henriksen, Jensen: Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells. dans Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2015
Human PLG Kit ELISA pour Sandwich ELISA - ABIN612752
Forsgren, Råden, Israelsson, Larsson, Hedén: Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. dans FEBS letters 1987
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Mouse (Murine) PLG Kit ELISA pour Sandwich ELISA - ABIN820647
Ly, Taylor, Tsatsaronis, Monteleone, Skora, Donald, Maddocks, Nizet, West, Ranson, Walker, McArthur, Sanderson-Smith: Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. dans Journal of innate immunity 2014
Human PLG Kit ELISA pour Sandwich ELISA - ABIN416924
Wang, Yuan, Zhong, Wen, Deng, Liang, Zheng: The anticoagulant effect of PGI2S and tPA in transgenic umbilical vein endothelial cells is linked to up-regulation of PKA and PKC. dans International journal of molecular sciences 2014
Ikezoe, Yang, Nishioka, Isaka, Iwabu, Sakai, Taniguchi, Honda, Yokoyama: Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells. dans Experimental hematology 2012
plasmin cleaves surface-bound CCL21 (Montrer CCL21 Kits ELISA) to release the C-terminal peptide responsible for CCL21 (Montrer CCL21 Kits ELISA) binding to glycosaminoglycans on the extracellular matrix and cell surfaces, thereby generating the soluble form.
Analysis of plasminogen genetic variants in multiple sclerosis patients has been reported.
Enolase of Mtb (Montrer NCAPG2 Kits ELISA) is present on its surface and binds human plasminogen with high affinity.
Data suggest that protein aggregates interact with tissue-type plasminogen activator (Montrer PLAT Kits ELISA) and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin (Montrer Alpha2 Antiplasmin Kits ELISA) and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
The mechanism for plasminogen/M protein (Montrer MYOM2 Kits ELISA) binding uncovered here may facilitate targeting of group A Streptococcus pyogenes virulence factors for disease management
t-PA (Montrer PLAT Kits ELISA) binds to Lys91 in the MBP (Montrer MBL2 Kits ELISA) NH2-terminal region and PLG binds to Lys122 in the MBP (Montrer MBL2 Kits ELISA) COOH-terminal region. This proximity promotes the activation of PLG by t-PA (Montrer PLAT Kits ELISA).
in the presence of platelet polyphosphate and the downstream substrate fibrin, alphaFXIIa is a highly efficient and favorable plasminogen activator.
Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer
Our findings indicate a new pathway for bradykinin formation in patients with HAE, in which FXII (Montrer F12 Kits ELISA) is cleaved and activated by plasmin.
VWF (Montrer VWF Kits ELISA) susceptibility to plasmin proteolysis at K1491-R1492 is modulated by local N-linked glycan expression within A1A2A3, and specifically inhibited by heparin binding to the A1 domain.
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
The current study suggests the existence of an active TNF-alpha (Montrer TNF Kits ELISA)-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.
examination of interaction with streptococcal plasminogen activator PauA
Variation in blood plasminogen levels, within the range seen in normal individuals, had marked effects on experimental ischemic brain injury
plasmin protease activity prevents dystrophic calcification within injured skeletal muscle independent of its canonical fibrinolytic function.
Plasminogen-deficient mice have extensive fibrin and neutrophil depositions in the wounded area long after re-epithelialisation, indicating inefficient debridement and chronic inflammation. Delayed formation of granulation tissue suggests that fibroblast function is impaired in the absence of plasminogen.
confirmed the ability of Plg/Pla to both promote efferocytosis and override the prosurvival effect of LPS (Montrer TLR4 Kits ELISA) via annexin A1 (Montrer ANXA1 Kits ELISA).
findings identify plasmin as a decisive checkpoint in the inflammatory response during Macrophage activation syndrome (MAS (Montrer MAS1 Kits ELISA)) and a potential novel therapeutic target for MAS (Montrer MAS1 Kits ELISA).
Deficiency of plasminogen delays onset of autoimmune neuroinflammatory disease and protects from the development of paralysis.
Plasminogen may regulate DPP-4 (Montrer DPP4 Kits ELISA) activity and glucose metabolism.
Plasminogen-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein (Montrer SLC11A2 Kits ELISA) C (Montrer PROC Kits ELISA) (MntC) is an extracellular matrix- and plasminogen-binding protein (Montrer ENO1 Kits ELISA)
Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (Montrer Lp-PLA2 Kits ELISA)), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
, lipoprotein, Lp(a)
, plasmin heavy chain A
, plasmin light chain B