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TCR beta Anticorps

(T Cell Receptor (TCR) beta (TCR beta))
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes several trypsinogen genes. [provided by RefSeq, Jul 2008]

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Catégories TCR beta en vedette

TCR beta Anticorps

High quality antibodies with extensive validation data.

TCR beta recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Application FACS
Validations
  • (1)
N° du produit ABIN7278222
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Application FACS
Validations
  • (1)
N° du produit ABIN7278032
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (1)
N° du produit ABIN3180910
Quantité 100 μL
Fiche technique Fiche technique

Dernières publications sur nos produits TCR beta

Flores-Villanueva, Ganachari, Guio, Mejia, Granados: "An Isolated TCR αβ Restricted by HLA-A*02:01/CT37 Peptide Redirecting CD8+ T Cells To Kill and Secrete IFN-γ in Response to Lung Adenocarcinoma Cell Lines." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 8, pp. 2965-2977, (2018) (PubMed).

Saint-Ruf, Panigada, Azogui, Debey, von Boehmer, Grassi: "Different initiation of pre-TCR and gammadeltaTCR signalling." dans: Nature, Vol. 406, Issue 6795, pp. 524-7, (2000) (PubMed).

Vicari, Zlotnik: "Mouse NK1.1+ T cells: a new family of T cells." dans: Immunology today, Vol. 17, Issue 2, pp. 71-6, (1996) (PubMed).

Wagner, Hagman, Linsley, Hodsdon, Freed, Newell: "Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2." dans: The Journal of experimental medicine, Vol. 184, Issue 5, pp. 1631-8, (1996) (PubMed).

Atsuta, Nishimura, Nakamura, Emoto, Iwatsuki, Yoshikai: "Diversity of V gamma gene segments rearranged to the J gamma 4 gene in mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 2, pp. 676-84, (1995) (PubMed).

Davenport, Kumar, Bennett: "Rapid rejection of H2k and H2k/b bone marrow cell grafts by CD8+ T cells and NK cells in irradiated mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 8, pp. 3742-9, (1995) (PubMed).

van der Heyde, Elloso, Chang, Kaplan, Manning, Weidanz: "Gamma delta T cells function in cell-mediated immunity to acute blood-stage Plasmodium chabaudi adami malaria." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 8, pp. 3985-90, (1995) (PubMed).

Bendelac, Killeen, Littman, Schwartz: "A subset of CD4+ thymocytes selected by MHC class I molecules." dans: Science (New York, N.Y.), Vol. 263, Issue 5154, pp. 1774-8, (1994) (PubMed).

Ohno, Ono, Hirayama, Shimada, Saito: "Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia." dans: The Journal of experimental medicine, Vol. 179, Issue 1, pp. 365-9, (1994) (PubMed).

Saint-Ruf, Ungewiss, Groettrup, Bruno, Fehling, von Boehmer: "Analysis and expression of a cloned pre-T cell receptor gene." dans: Science (New York, N.Y.), Vol. 266, Issue 5188, pp. 1208-12, (1994) (PubMed).

Synonymes et noms alternatifs relatifs à TCR beta

T cell receptor beta chain (Tcrb), TCRbeta, Tib

Protein level used designations for TCR beta

  • T-cell receptor beta chain
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