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anti-Human Filamin A Anticorps:
anti-Mouse (Murine) Filamin A Anticorps:
anti-Rat (Rattus) Filamin A Anticorps:
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Human Monoclonal Filamin A Primary Antibody pour IHC (p), PLA - ABIN560922
Valente, Logan, Mougou-Zerelli, Lee, Silhavy, Brancati, Iannicelli, Travaglini, Romani, Illi, Adams, Szymanska, Mazzotta, Lee, Tolentino, Swistun, Salpietro, Fede, Gabriel, Russ, Cibulskis, Sougnez et al.: Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. ... dans Nature genetics 2010
Show all 8 Pubmed References
Human Monoclonal Filamin A Primary Antibody pour WB - ABIN1882243
Gorlin, Yamin, Egan, Stewart, Stossel, Kwiatkowski, Hartwig: Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. dans The Journal of cell biology 1990
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Human Polyclonal Filamin A Primary Antibody pour ICC, IF - ABIN188803
Thoms, Loveridge, Simpson, Clipson, Reinhardt, Dunlop, Stark: Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination. dans Cancer research 2010
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FLNA overexpression suppressed the proliferation of Bladder Carcinoma cells, blocked cell cycle and promoted apoptosis of Bladder Carcinoma cell.
Silencing filamin A (FLNa) expression in lung cancer cell line A549 cells promoted proliferation, migration, and invasiveness of A549 cells by enhancing the activation of epidermal growth factor receptor (Montrer EGFR Anticorps) and ERK (Montrer EPHB2 Anticorps) signaling pathway.
The interaction between tissue factor (Montrer F3 Anticorps) and filamin A is dependent on the differential phosphorylation of Ser253 and Ser258. The interaction with filamin A may translocate cell surface TF to cholesterol-rich lipid rafts, increasing cell surface TF activity as well as TF incorporation and release into microvesicles.
Reduced RNA editing of FLNA gene is associated with psoriasis.
Data indicate mutations in FLNA (Filamin A) associated with Ebstein anomaly.
these observations describe a new mechanism of tissue-specific regulation of FLNA that could reflect the differing mechanical requirements of these cell types during development.
This study also indicates that FLNA may affect white matter integrity in patients with periventricular nodular heterotopia related epilepsy.
The mutations of the FLNA gene were observed in 7 (30.4%) of the 23 patients who with Sporadic periventricular nodular heterotopia.
Data show that AR-deficient and highly metastatic prostate cancer cell lines express higher levels of filamin A compared to normal prostate epithelial cells and AR-positive and less metastatic prostate cancer. Also, the results identified that Cao2+ via CaR-mediated signaling induces filamin A cleavage and promotes the migration in AR-deficient and highly metastatic prostate cancer cells.
FLNA is downregulated in parathyroid tumors and parallels the CASR (Montrer CASR Anticorps) expression levels. Loss of FLNA reduces CASR (Montrer CASR Anticorps) mRNA and protein expression levels and the CASR (Montrer CASR Anticorps)-induced ERK (Montrer EPHB2 Anticorps) phosphorylation. FLNA is involved in receptor expression, membrane localization and ERK (Montrer EPHB2 Anticorps) signaling activation of both 990R and 990G CASR (Montrer CASR Anticorps) variants.
filamin reduces ENaC (Montrer SCNN1A Anticorps) channel function through direct interaction on the cell surface
Knockdown of filamin A or vimentin (Montrer VIM Anticorps) in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells.
FlnA and Fmn2 (Montrer FMN2 Anticorps) are likely essential to cell proliferation, differentiation and cell death in a variety of tissues and organs, further reiterating the importance of vesicle trafficking in regulation of development
both LRP1 (Montrer LRP1 Anticorps) and LDLR (Montrer LDLR Anticorps) expression and agLDL uptake are regulated by P2Y2R (Montrer P2RY2 Anticorps) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (Montrer P2RY2 Anticorps) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (Montrer P2RY2 Anticorps) binding to FLN-A
FlnA is a negative regulator of beta2 integrin-dependent cell adhesion and reactive oxygen species production but is required for neutrophil extracellular traps production in primary murine neutrophils
Here the authors report that intermediate progenitor's neuron production is enhanced by abrogating filamin function, leading to the generation of periventricular neurons independent of normal neocortical neurogenesis and neuronal migration.
These results show that FLNA plays crucial roles in asymmetric division during meiotic maturation by regulating ROCK-cofilin-mediated actin reorganization.
FlnA binding to PACSIN2 (Montrer PACSIN2 Anticorps) F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
FlnA is a critical upstream element of the signaling cascade underlying the myogenic tone.
Bones lacking filamin A are protected from estrogen-mediated post-menopausal osteoporosis
findings suggest a model in which filamin A local translation following axon injury controls localized HDAC5 (Montrer HDAC5 Anticorps) activity to promote axon regeneration.
Deletion of filamin A in endothelial cells aggravated myocardial infarction-induced left ventricle dysfunction and cardiac failure as a result of defective endothelial response
The PDZ domain (Montrer INADL Anticorps) binding motif found in the most C-terminal region of the Sema (Montrer SEMA3B Anticorps)-1a ICD is necessary for interaction with Vari, but not Cher, indicative of distinct binding modalities. Pbl/Sema (Montrer SEMA3B Anticorps)-1a-mediated repulsive guidance is potentiated by both vari and cher Genetic analyses further suggest that scaffolding functions of Vari and Cher play an important role in Pbl-mediated Sema (Montrer SEMA3B Anticorps)-1a reverse signaling.
FLN90, an isoform of the Drosophila ortholog Filamin/cheerio that lacks the actin (Montrer ACTB Anticorps)-binding domain, is here shown to govern the growth of postsynaptic membrane folds and the composition of glutamate (Montrer GRIN2A Anticorps) receptor clusters at the larval neuromuscular junction.
Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc. We identify the filamin domains required for interaction with the titin ortholog Sallimus, and we demonstrate a genetic interaction of filamin with titin and actin.
study identifies Cher as a new target of JNK (Montrer MAPK8 Anticorps) signaling that links cytoskeleton dynamics to tumor progression.
Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.
Filamin is required for ovarian follicle cell motility during oogenesis.
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
actin binding protein 280
, endothelial actin-binding protein
, non-muscle filamin
, filamin A, alpha (actin binding protein 280)
, GENA 379
, actin-binding protein 280
, dilated pupils 2
, filamin A
, Endothelial actin-binding protein 280)
, filamin, alpha
, filamin A, alpha
, filamin B
, filamin isoform B
, shi kong
, 450 kDa protein