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anti-Human GAB2 Anticorps:
anti-Rat (Rattus) GAB2 Anticorps:
anti-Mouse (Murine) GAB2 Anticorps:
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Human Polyclonal GAB2 Primary Antibody pour FACS, WB - ABIN1881358
Yamasaki, Nishida, Hibi, Sakuma, Shiina, Takeuchi, Ohnishi, Hirano, Saito: Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. dans The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human Polyclonal GAB2 Primary Antibody pour IHC, IHC (p) - ABIN4313051
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. dans Molecular & cellular proteomics : MCP 2006
Human Polyclonal GAB2 Primary Antibody pour IF (p), IHC (p) - ABIN681178
Zhan, Xu, Chen, Wang, Yanfeng, Dan, Zhan, Shi: Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. dans Synapse (New York, N.Y.) 2014
Human Polyclonal GAB2 Primary Antibody pour ELISA, WB - ABIN253292
Bentires-Alj, Gil, Chan, Wang, Wang, Imanaka, Harris, Richardson, Neel, Gu: A role for the scaffolding adapter GAB2 in breast cancer. dans Nature medicine 2006
Gab2 is overexpressed in UMs (Montrer TBX3 Anticorps) and plays an important role in UM invasion. Moreover, our findings suggest a novel role for Gab2 in modulating MMP-2 (Montrer MMP2 Anticorps), MMP-9 (Montrer MMP9 Anticorps), and fascin (Montrer FSCN1 Anticorps) expression in regulating the invasion of UM tumor cells
a common locus (rs3740677) in 3' UTR of GAB2 sequence which is targeted by the miRNA-185 was explored the probable associations of rs3740677 with risk for late-onset AD (LOAD) in a large scale case-control study from Chinese Han populations.
we provided evidences to imply that miR (Montrer MLXIP Anticorps)-302c-3p downregulation in human RCC (Montrer XRCC1 Anticorps) cells causes Gab2 over-expression, Akt (Montrer AKT1 Anticorps) hyper-activation and cell proliferation.
study identified that GAB2 as an adaptor protein was preferentially induced in Th2 differentiation and regulated Th2 immune responses
The proto-oncogene (Montrer RAB1A Anticorps) GAB2 (11q14.1) was significantly amplified in non-smokers patients and GAB2 protein was relatively up-regulated in non-smoker than smoker tissues. GAB2 may represent a potential biomarker for lung SCC (Montrer CYP11A1 Anticorps) in non-smokers
There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 rs2373115 (G > T) and PICALM (Montrer PICALM Anticorps) rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM (Montrer PICALM Anticorps) was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 (Montrer SORL1 Anticorps) were significantly associated with AD.
Results show that up-regulation of Gab2 expression was found to be positively correlated with VEGF (Montrer VEGFA Anticorps) in colorectal cancer (CRC (Montrer CALR Anticorps)) tissues, and suggest that Gab2 promotes intestinal tumor growth and angiogenesis through upregulation of VEGF (Montrer VEGFA Anticorps) expression mediated by the MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps)/c-Myc (Montrer MYC Anticorps) pathway.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 and their complexes with Shp2 (Montrer PTPN11 Anticorps). VEGFR2 (Montrer KDR Anticorps) recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 (Montrer KDR Anticorps) complexes more transiently than Gab1, VEGFR2 (Montrer KDR Anticorps) complexes can recycle and continue to participate in other signaling pathways.
The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.
Studied BAK1 (Montrer BAK1 Anticorps), SPRY4 (Montrer SPRY4 Anticorps) and GAB2 SNPs in pediatric germ cell tumors(GCT (Montrer QPCT Anticorps)); found a variant in SPRY4 (Montrer SPRY4 Anticorps) was associated with reduced risk of GCT (Montrer QPCT Anticorps); a variant in BAK1 (Montrer BAK1 Anticorps) was positively associated with GCT (Montrer QPCT Anticorps) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (Montrer QPCT Anticorps).
The results of this study showed that the reactive Schwann cells exhibit migratory features dependent on the expression of a scaffolding oncoprotein Grb2-associated binder-2 (Gab2), which was transcriptionally induced by neuregulin 1 (Montrer NRG1 Anticorps)-ErbB2 (Montrer ERBB2 Anticorps) signaling following nerve injury.
we demonstrated for the first time that Gab2 deficiency has a profound effect on the course of disease in an in vivo chronic myeloid leukemia (Montrer BCL11A Anticorps) model
High Gab2 expression is associated with myeloproliferative neoplasm.
Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r (Montrer IL4R Anticorps), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (Montrer IL4R Anticorps) = interleukin-4 receptor (Montrer IL4R Anticorps))
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin (Montrer SLC13A2 Anticorps) gene expression and GCH (Montrer GCH1 Anticorps); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97