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anti-Human GAB2 Anticorps:
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Human Polyclonal GAB2 Primary Antibody pour FACS, WB - ABIN1881358
Yamasaki, Nishida, Hibi, Sakuma, Shiina, Takeuchi, Ohnishi, Hirano, Saito: Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. dans The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human Polyclonal GAB2 Primary Antibody pour IF (p), IHC (p) - ABIN681178
Zhan, Xu, Chen, Wang, Yanfeng, Dan, Zhan, Shi: Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. dans Synapse (New York, N.Y.) 2014
Human Polyclonal GAB2 Primary Antibody pour ELISA, WB - ABIN253292
Bentires-Alj, Gil, Chan, Wang, Wang, Imanaka, Harris, Richardson, Neel, Gu: A role for the scaffolding adapter GAB2 in breast cancer. dans Nature medicine 2006
Human Polyclonal GAB2 Primary Antibody pour IHC, IHC (p) - ABIN4313051
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. dans Molecular & cellular proteomics : MCP 2006
PIK3R1 loss activates AKT and p110-independent JAK2/STAT3 signaling through inducing changes in the phosphorylation of the docking protein Gab2, thereby relieving the negative inhibition on AKT and promoting the assembly of JAK2/STAT3 signalosome, respectively.
Alzheimer's Disease risk variant rs2373115 is associated with increased NARS2 expression in brain. GAB2 expression is increased in AD brain tissue.
Knockdown of Gab2 suppressed the activity of both PI3K/AKT and MAPK/ERK pathways in HER2-overexpressing breast cancer cells.
these findings demonstrate that miR-485 may play tumour suppressive roles in Colorectal cancer (CRC)by directly targeting GAB2 and indirectly regulating AKT and ERK signalling pathways, suggesting that miR-485 may be a potential therapeutic target for patients with this disease
Gab2 is overexpressed in UMs and plays an important role in UM invasion. Moreover, our findings suggest a novel role for Gab2 in modulating MMP-2, MMP-9, and fascin expression in regulating the invasion of UM tumor cells
a common locus (rs3740677) in 3' UTR of GAB2 sequence which is targeted by the miRNA-185 was explored the probable associations of rs3740677 with risk for late-onset AD (LOAD) in a large scale case-control study from Chinese Han populations.
we provided evidences to imply that miR-302c-3p downregulation in human RCC cells causes Gab2 over-expression, Akt hyper-activation and cell proliferation.
study identified that GAB2 as an adaptor protein was preferentially induced in Th2 differentiation and regulated Th2 immune responses
The proto-oncogene GAB2 (11q14.1) was significantly amplified in non-smokers patients and GAB2 protein was relatively up-regulated in non-smoker than smoker tissues. GAB2 may represent a potential biomarker for lung SCC in non-smokers
There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 rs2373115 (G > T) and PICALM rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 were significantly associated with AD.
Results show that up-regulation of Gab2 expression was found to be positively correlated with VEGF in colorectal cancer (CRC) tissues, and suggest that Gab2 promotes intestinal tumor growth and angiogenesis through upregulation of VEGF expression mediated by the MEK/ERK/c-Myc pathway.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 and their complexes with Shp2. VEGFR2 recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 complexes more transiently than Gab1, VEGFR2 complexes can recycle and continue to participate in other signaling pathways.
The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.
Studied BAK1, SPRY4 and GAB2 SNPs in pediatric germ cell tumors(GCT); found a variant in SPRY4 was associated with reduced risk of GCT; a variant in BAK1 was positively associated with GCT with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT.
overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1, CXCL2 and CXCL8 that is IKKbeta-dependent.
GAB2 is a key intermediary between YAP/TAZ and the PI3K/AKT pathway.
The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population.
ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation.
GAB2 is a functional downstream target of miR-302a in glioma. GAB2 role in cell proliferation, migration and invasion of glioma.
overexpression of GAB2 suppressed the expression of miR197 in glioblastoma cells.
The results of this study showed that the reactive Schwann cells exhibit migratory features dependent on the expression of a scaffolding oncoprotein Grb2-associated binder-2 (Gab2), which was transcriptionally induced by neuregulin 1-ErbB2 signaling following nerve injury.
we demonstrated for the first time that Gab2 deficiency has a profound effect on the course of disease in an in vivo chronic myeloid leukemia model
High Gab2 expression is associated with myeloproliferative neoplasm.
Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r, synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r = interleukin-4 receptor)
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin gene expression and GCH; these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
Data indicate that fetal liver cells isolated from homozygous STAT5 mutant mice lacking Gab2 showed significant reduction in HSC number and survival.
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.
comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat
Transfected Gab2 is a limiting signaling component for Erk MAP kinase activation and terminal differentiation of K562 CML cells.
Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.
role in beta1-integrin signaling pathway hematooietic stem cell adhesion and migration
distinct recruitment and function in Met receptor-mediated epithelial morphogenesis
Gads/Grb2-mediated LAT association is critical for the inhibitory function of Gab2
Gab2 is recruited to the nascent phagosome, where de novo PI3K lipid production occurs. Gab2 recruitment requires the pleckstrin homology domain of Gab2.
data propose that Lyn, not Jak2, phosphorylates Gab2 and that maximal phosphorylation of Gab2 requires Y764, a Grb2-binding site.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97