anti-Souris IL17A anticorps pour Biochemical Assay

Recommended IL17A Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Interleukin 17A (IL17A) Anticorps
  • CTLA8
  • IL-17
  • IL-17A
  • IL17
  • Ctla-8
  • Ctla8
  • Il17
  • ChIL-17
  • IL-17F
  • IL17A
  • CTLA-8
  • interleukin 17A
  • IL17A
  • Il17a
Reactivité
Souris
371
130
40
7
7
5
3
3
2
2
Hôte
Rat
248
131
76
40
3
3
Clonalité
Monoclonal
Conjugué
Cet anticorp IL17A est non-conjugé
56
32
27
22
20
16
15
15
11
11
7
7
7
7
7
5
5
5
4
4
4
4
4
4
3
2
2
1
Application
Biochemical Assay (BCA)
268
228
195
42
30
20
18
16
8
8
7
7
7
6
6
4
4
3
3
3
2
1
1
1
1
1
1
1
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N° du produit ABIN2665823
Produit non disponible pour cette région.

General

Antigène Interleukin 17A (IL17A) Anticorps
Reactivité Souris
(371), (130), (40), (7), (7), (5), (3), (3), (2), (2)
Hôte Rat
(248), (131), (76), (40), (3), (3)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp IL17A est non-conjugé
(56), (32), (27), (22), (20), (16), (15), (15), (11), (11), (7), (7), (7), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (1)
Application Biochemical Assay (BCA)
(268), (228), (195), (42), (30), (20), (18), (16), (8), (8), (7), (7), (7), (6), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 6 références disponible
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Détail du produit anti-IL17A anticorps

Détail du antigène IL17A Information d'application Stockage References for anti-IL17A antibody (ABIN2665823) Images
Marque LEAF™
Purification The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Stérilité 0.2 μm filtered
niveau d'endotoxine

Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.

Clone TC11-8H4
Isotype IgG1 kappa

Détail du antigène IL17A

Détail du produit anti-IL17A anticorps Information d'application Stockage References for anti-IL17A antibody (ABIN2665823) Images Haut de la page
Antigène
Autre désignation IL-17A (IL17A Antibody Extrait)
Sujet IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. Recent study has shown that IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. The TC11-8H4 antibody antibody reacts with mouse interleukin-17 (IL-17).

Information d'application

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Stockage References for anti-IL17A antibody (ABIN2665823) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Information d'application References for anti-IL17A antibody (ABIN2665823) Images Haut de la page
Concentration 1.0 mg/mL
Agent conservateur Azide free
Conseil sur la manipulation This LEAF™ solution contains no preservative, handle under aseptic conditions
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL17A antibody (ABIN2665823)

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Information d'application Stockage Images Haut de la page
Background publications

Herrada, Contreras, Marini, Amador, González, Cortés, Riedel, Carvajal, Figueroa, Michea, Fardella, Kalergis: "Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 1, pp. 191-202, 2009

Dong: "Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells." dans: Nature reviews. Immunology, Vol. 6, Issue 4, pp. 329-33, 2006

Hofstetter, Ibrahim, Koczan, Kruse, Weishaupt, Toyka, Gold: "Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis." dans: Cellular immunology, Vol. 237, Issue 2, pp. 123-30, 2006

Yao, Spriggs, Derry, Strockbine, Park, VandenBos, Zappone, Painter, Armitage: "Molecular characterization of the human interleukin (IL)-17 receptor." dans: Cytokine, Vol. 9, Issue 11, pp. 794-800, 1998

Kennedy, Rossi, Zurawski, Vega, Kastelein, Wagner, Hannum, Zlotnik: "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells." dans: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 16, Issue 8, pp. 611-7, 1997

Fossiez, Djossou, Chomarat, Flores-Romo, Ait-Yahia, Maat, Pin, Garrone, Garcia, Saeland, Blanchard, Gaillard, Das Mahapatra, Rouvier, Golstein, Banchereau, Lebecque: "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." dans: The Journal of experimental medicine, Vol. 183, Issue 6, pp. 2593-603, 1996