anti-Souris IL17A anticorps pour Intracellular Flow Cytometry

Recommended IL17A Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Interleukin 17A (IL17A) Anticorps
  • CTLA8
  • IL-17
  • IL-17A
  • IL17
  • Ctla-8
  • Ctla8
  • Il17
  • ChIL-17
  • IL-17F
  • IL17A
  • CTLA-8
  • interleukin 17A
  • IL17A
  • Il17a
Reactivité
Souris
371
130
40
7
7
5
3
3
2
2
Hôte
Rat
248
131
76
40
3
3
Clonalité
Monoclonal
Conjugué
Cet anticorp IL17A est conjugé à/à la FITC
56
32
26
22
20
16
15
15
11
11
7
7
7
7
7
5
5
5
4
4
4
4
4
4
3
2
2
1
Application
Intracellular Flow Cytometry (ICFC)
268
228
195
42
30
20
18
16
8
8
7
7
7
6
6
4
4
3
3
3
2
1
1
1
1
1
1
1
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N° du produit ABIN2661940
Produit non disponible pour cette région.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN2661939 ICFC FITC Rat IgG1 kappa Connectez-vous pour afficher TC11-18H10-1 11

General

Antigène Interleukin 17A (IL17A) Anticorps
Reactivité Souris
(371), (130), (40), (7), (7), (5), (3), (3), (2), (2)
Hôte Rat
(248), (131), (76), (40), (3), (3)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp IL17A est conjugé à/à la FITC
(56), (32), (26), (22), (20), (16), (15), (15), (11), (11), (7), (7), (7), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (1)
Application Intracellular Flow Cytometry (ICFC)
(268), (228), (195), (42), (30), (20), (18), (16), (8), (8), (7), (7), (7), (6), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 11 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-IL17A anticorps

Détail du antigène IL17A Information d'application Stockage References for anti-IL17A antibody (ABIN2661940) Images
Purification The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone TC11-18H10-1
Isotype IgG1 kappa

Détail du antigène IL17A

Détail du produit anti-IL17A anticorps Information d'application Stockage References for anti-IL17A antibody (ABIN2661940) Images Haut de la page
Antigène
Autre désignation IL-17A (IL17A Antibody Extrait)
Sujet IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Information d'application

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Stockage References for anti-IL17A antibody (ABIN2661940) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Information d'application References for anti-IL17A antibody (ABIN2661940) Images Haut de la page
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Protect from prolonged exposure to light. Do not freeze.
Stock 4 °C
Stockage commentaire The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL17A antibody (ABIN2661940)

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Information d'application Stockage Images Haut de la page
Background publications

Smith, Stark, Zarbock, Burcin, Bruce, Vaswani, Foley, Ley: "IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 2, pp. 1357-64, 2008

Ehirchiou, Xiong, Xu, Chen, Shi, Zhang: "CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation." dans: The Journal of experimental medicine, Vol. 204, Issue 7, pp. 1519-24, 2007

Kang, Lim, Andrisani, Broxmeyer, Kim: "Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 6, pp. 3724-33, 2007

Dong: "Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells." dans: Nature reviews. Immunology, Vol. 6, Issue 4, pp. 329-33, 2006

Hofstetter, Ibrahim, Koczan, Kruse, Weishaupt, Toyka, Gold: "Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis." dans: Cellular immunology, Vol. 237, Issue 2, pp. 123-30, 2006

Yen, Cheung, Scheerens, Poulet, McClanahan, McKenzie, Kleinschek, Owyang, Mattson, Blumenschein, Murphy, Sathe, Cua, Kastelein, Rennick: "IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6." dans: The Journal of clinical investigation, Vol. 116, Issue 5, pp. 1310-6, 2006

Schubert, Maier, Morawietz, Krenn, Kamradt: "Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 4503-9, 2004

Infante-Duarte, Horton, Byrne, Kamradt: "Microbial lipopeptides induce the production of IL-17 in Th cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6107-15, 2000

Yao, Spriggs, Derry, Strockbine, Park, VandenBos, Zappone, Painter, Armitage: "Molecular characterization of the human interleukin (IL)-17 receptor." dans: Cytokine, Vol. 9, Issue 11, pp. 794-800, 1998

Kennedy, Rossi, Zurawski, Vega, Kastelein, Wagner, Hannum, Zlotnik: "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells." dans: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 16, Issue 8, pp. 611-7, 1997

Fossiez, Djossou, Chomarat, Flores-Romo, Ait-Yahia, Maat, Pin, Garrone, Garcia, Saeland, Blanchard, Gaillard, Das Mahapatra, Rouvier, Golstein, Banchereau, Lebecque: "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." dans: The Journal of experimental medicine, Vol. 183, Issue 6, pp. 2593-603, 1996

Images

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Information d'application Stockage References for anti-IL17A antibody (ABIN2661940) Haut de la page
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 17A (IL17A) antibody (FITC) (ABIN2661940) anti-Interleukin 17A (IL17A) antibody (FITC)