anti-Souris IL17A anticorps pour Blocking Antibody

Recommended IL17A Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Interleukin 17A (IL17A) Anticorps
  • CTLA8
  • IL-17
  • IL-17A
  • IL17
  • Ctla-8
  • Ctla8
  • Il17
  • ChIL-17
  • IL-17F
  • IL17A
  • CTLA-8
  • interleukin 17A
  • IL17A
  • Il17a
Reactivité
Souris
371
130
40
7
7
5
3
3
2
2
Hôte
Rat
248
131
76
40
3
3
Clonalité
Monoclonal
Conjugué
Cet anticorp IL17A est non-conjugé
56
32
27
22
20
16
15
15
11
11
7
7
7
7
7
5
5
5
4
4
4
4
4
4
3
2
2
1
Application
Blocking Antibody (Inhibition), Neutralization (Neut), ELISA, Western Blotting (WB)
267
227
195
42
29
20
18
16
8
8
7
7
7
6
6
4
4
3
3
3
2
1
1
1
1
1
1
1
Options
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N° du produit ABIN2689741
Produit non disponible pour cette région.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN636682 Inhibition ELISA WB Rabbit Connectez-vous pour afficher Polyclonal
1 ABIN2689742 Inhibition Neut ELISA WB Rat IgG1, kappa Connectez-vous pour afficher TC11

General

Antigène Interleukin 17A (IL17A) Anticorps
Reactivité Souris
(371), (130), (40), (7), (7), (5), (3), (3), (2), (2)
Hôte Rat
(248), (131), (76), (40), (3), (3)
Clonalité (Clone)
Monoclonal   ( )
Conjugué Cet anticorp IL17A est non-conjugé
(56), (32), (27), (22), (20), (16), (15), (15), (11), (11), (7), (7), (7), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (1)
Application Blocking Antibody (Inhibition), Neutralization (Neut), ELISA, Western Blotting (WB)
(267), (227), (195), (42), (29), (20), (18), (16), (8), (8), (7), (7), (7), (6), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 2 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-IL17A anticorps

Détail du antigène IL17A Information d'application Stockage References for anti-IL17A antibody (ABIN2689741) Images
Marque BD Pharmingen™
Attributs du produit The TC11-18H10 antibody reacts with recombinant and natural mouse IL-17A proteins. IL-17A, also known as CTLA-8, is a T cell-derived cytokine that promotes inflammatory responses. Mouse IL-17A is a proinflammatory cytokine that can induce the release of IL-6 by mouse stromal cells. It has been shown to support the growth of hemopoietic progenitors in vitro, it can also stimulate granulopoiesis in vivo. The TC11-18H10 antibody has been reported to neutralize IL-17A activity. Recent studies have shown that IL-17A is produced by a unique subset of Th17 cells that develop along a pathway distinct from the Th1- and Th2- cell differentiation pathways. The mouse IL-17A cDNA was isolated from a cDNA library generated from TCRαβ+CD4-CD8-thymocytes. Characterization of IL-17A-producing cells within a stimulated mouse EL4 thymoma cell population. EL4 cells were cultured overnight in the presence of GolgiPlug™ (1 μg/mL final concentration, Cat. No. 555029) without (left panel) or with PMA (5 ng/mL final concentration, Sigma, Cat. No. P-8139) and Ionomycin (500 ng/mL final concentration, Sigma, Cat. No.I-0634) (middle and right panels). The cells were fixed, permeabilized and subsequently stained with 0.125 μg of PE conjugated anti-mouse IL-17A (PE-TC11-18H10, Cat. No.559502) using BD Pharmingen I/C staining protocol (left and middle panels) . To demonstrate the specificity of staining, the binding of PE-TC11-18H10 was blocked by the preincubation of the fixed/permeabilized, stimulated EL4 cells with unlabeled TC11-18H10 antibody (10 μg, right panel). The quadrant markers for the bivariate dot plots were set based on the autofluorescence control, and verified with the unstimulated stained (left panel) and unlabeled antibody blocking (right panel) controls.

BD Pharmingen™ Purified Rat Anti-Mouse IL-17A - Purified - Clone TC11-18H10 - Isotype Rat IgG1, κ - Reactivity Ms - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogène Recombinant Mouse IL-17 Protein
Clone TC11
Isotype IgG1, kappa

Détail du antigène IL17A

Détail du produit anti-IL17A anticorps Information d'application Stockage References for anti-IL17A antibody (ABIN2689741) Images Haut de la page
Antigène
Autre désignation IL-17A (IL17A Antibody Extrait)

Information d'application

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Stockage References for anti-IL17A antibody (ABIN2689741) Images Haut de la page
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Stockage

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Information d'application References for anti-IL17A antibody (ABIN2689741) Images Haut de la page
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store undiluted at 4°C.

References for anti-IL17A antibody (ABIN2689741)

Détail du produit anti-IL17A anticorps Détail du antigène IL17A Information d'application Stockage Images Haut de la page
Produit citée dans:

Schwarzenberger, La Russa, Miller, Ye, Huang, Zieske, Nelson, Bagby, Stoltz, Mynatt, Spriggs, Kolls: "IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6383-9, 1998

Prussin, Metcalfe: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." dans: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, 1996