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Human Monoclonal INPP5D Primary Antibody pour ELISA, WB - ABIN2476468
Rohrschneider, Fuller, Wolf, Liu, Lucas: Structure, function, and biology of SHIP proteins. dans Genes & development 2000
We investigated the role of SHIP1 as a tumor suppressor in myeloid leukemia (Montrer BCL11A Anticorps) cells in an in vivo xenograft transplantation model. The AML (Montrer RUNX1 Anticorps)-derived SHIP1Y643H mutant, which has a strongly reduced enzymatic activity showed significant reversion of SHIP1-induced prolongation of the survival time. In addition, analysis of 290 patients revealed a correlation between expression of SHIP1 and overall survival of the AML (Montrer RUNX1 Anticorps) patients.
High SHIP1 expression is associated with lymphoma and colon cancer.
These results show that SHIP-1 is required for the maintenance of B10 cells and production of IL-10 (Montrer IL10 Anticorps), and collectively suggests that SHIP-1 could be a new potential therapeutic target for the treatment of autoimmune diseases.
Rictor (Montrer RICTOR Anticorps) positively regulates B cell receptor signaling via up-regulating Btk (Montrer BTK Anticorps) and down-regulating SH2-containing inositol phosphatase
MiR (Montrer MLXIP Anticorps)-155 promotes experimental colitis by repressing SHIP-1 expression.
Results are consistent with predicted/observed reduction in the Lyn-SHIP-1-PTEN-SHP-1 axis function in B cells from systemic lupus
SHIP has a role in extracellular matrix accumulation via suppressing PI3K/Akt (Montrer AKT1 Anticorps)/CTGF (Montrer CTGF Anticorps) signaling in diabetic kidney dise
this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a (Montrer INPP4A Anticorps), and accelerates phagosome acidification
Data (including data from studies in knockout mice) suggest that up-regulation of signaling in colonic mucosa via interleukin-10 (Montrer IL10 Anticorps)/microRNA-155/SHIP-1 (Src homology 2 domain-containing inositol-5-phosphatase) is involved in development of colitis due to dysbiosis.
Our results describe a critical role for SHIP-1 in regulating the ability of dendritic cells to efficiently prime Th2-type responses.
Overall evidence did not indicate that inositol polyphosphate-5-phosphatase (Montrer INPP5E Anticorps) (INPP5D) rs35349669 single nucleotide polymorphism play a role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in Chinese population.
JARID1B (Montrer KDM5B Anticorps) directly bound to PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps) signaling inhibitor SHIP1 gene promoter and decreased SHIP1 gene expression.
Study shows that SHIP1 activity is decreased in adult Crohn's disease (CD) patients either through reduced intrinsic enxymatic activity or reduced protein expression, and propose that in addition to ATG16L1 (Montrer ATG16L1 Anticorps), SHIP1 may contribute to the risk conferred by the 2q37 CD risk locus.
results indicate that FcgammaRIIB is not uniquely able to promote membrane recruitment of SHIP, but rather modulates its function via formation of distinct signaling complexes. Membrane recruitment of SHIP via Syk (Montrer SYK Anticorps)-dependent mechanisms may be an important factor modulating immunoreceptor signaling.
SHIP has a role in extracellular matrix accumulation via suppressing PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/CTGF (Montrer CTGF Anticorps) signaling in diabetic kidney dise
SHIP levels and activity are lower in intestinal tissues and peripheral blood samples from patients with Crohn's disease, resulting in induction of Il1-beta (Montrer IL1B Anticorps).
Underexpression of SHIP1 is associated with drug resistance in acute myeloid leukemia (Montrer BCL11A Anticorps).
ectopically expressed SHIP1 accumulates in nucleolar cavities and colocalizes with the tumor suppressor protein p53 (Montrer TP53 Anticorps).
Results show that expression of SHIP1 protein is targeted by miR (Montrer MLXIP Anticorps)-155 in acute myeloid leukemia (Montrer BCL11A Anticorps) (AML (Montrer RUNX1 Anticorps)) suggesting it as an onco-miR (Montrer MLXIP Anticorps). The miR (Montrer MLXIP Anticorps)-155/SHIP1/PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps) signaling pathway could play an important role in the pathogenesis of AML (Montrer RUNX1 Anticorps).
Overexpression of miR (Montrer MLXIP Anticorps)-155 in the gouty synovial fluid mononuclear cells leads to suppress SHIP-1 levels and enhance proinflammatory cytokines.
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
inositol polyphosphate-5-phosphatase, 145kDa
, SH2 containing inositol phosphatase
, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like
, SH2 domain-containing inositol 5'-phosphatase 1
, SH2 domain-containing inositol phosphatase 1
, SH2 domain-containing inositol-5'-phosphatase 1
, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
, SH2 containing inositol phosphotase
, SH2-containing inositol phosphatase SHIP
, Src homology 2 domain-containing inositol-5-phosphatase
, inositol polyphosphate-5-phosphatase of 145 kDa
, inositol polyphosphate-5-phosphatase, 145 kDa
, Inositol polyphosphate-5-phosphatase 145 kDa
, Inositol polyphosphate-5-phosphatase, 145 kDa
, signaling inositol polyphosphate 5 phosphatase SIP-145