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anti-Mouse (Murine) LCP2 Anticorps:
anti-Rat (Rattus) LCP2 Anticorps:
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Human Monoclonal LCP2 Primary Antibody pour IP, WB - ABIN2476521
Sarrafian: Fasciotomy of the foot: an anatomical study with special reference to release of the calcaneal compartment. dans Foot & ankle 1990
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Human Monoclonal LCP2 Primary Antibody pour ICS - ABIN1177174
Fang, Motto, Ross, Koretzky: Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. dans Journal of immunology (Baltimore, Md. : 1950) 1996
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Human Monoclonal LCP2 Primary Antibody pour ICS - ABIN1177173
Wu, Koretzky: The SLP-76 family of adapter proteins. dans Seminars in immunology 2004
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Human Monoclonal LCP2 Primary Antibody pour ICS - ABIN1176934
Bonilla, Fujita, Pivniouk, Chan, Geha: Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III. dans Proceedings of the National Academy of Sciences of the United States of America 2000
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Human Polyclonal LCP2 Primary Antibody pour IHC, ELISA - ABIN1532089
Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... dans The Journal of biological chemistry 2012
Human Polyclonal LCP2 Primary Antibody pour ELISA, WB - ABIN2476520
Ackermann: [Change and new knowledge in infectious diseases of the nervous system]. dans Der Internist 1978
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Human Monoclonal LCP2 Primary Antibody pour ICS - ABIN1176936
Bubeck Wardenburg, Fu, Jackman, Flotow, Wilkinson, Williams, Johnson, Kong, Chan, Findell: Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. dans The Journal of biological chemistry 1996
Human Polyclonal LCP2 Primary Antibody pour ELISA, WB - ABIN250246
Jackman, Motto, Sun, Tanemoto, Turck, Peltz, Koretzky, Findell: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. dans The Journal of biological chemistry 1995
Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cgamma1 and the protein kinases AKT and ERK1/2, was increased
slp-76 contributes to the regulation of the tissue distribution, PLZF (Montrer ZBTB16 Anticorps), and cytokine expression of iNKT cells via ADAP (Montrer APP Anticorps)-dependent and -independent mechanisms.
findings identify ACK1 (Montrer TNK2 Anticorps) as a novel SLP-76-associated protein-tyrosine kinase (Montrer YES1 Anticorps) that modulates early activation events in T cells.
immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (Montrer RANGAP1 Anticorps) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (Montrer NFATC1 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) p65 (Montrer NFkBP65 Anticorps) nuclear entry in T cells
these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice
Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees.
this analysis identified 65 proteins not associated before with the Zap70 (Montrer ZAP70 Anticorps)-Lat (Montrer LAT Anticorps)-SLP-76 network and thus should provide cues for future functional experiments.
A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1 (Montrer PRAM1 Anticorps)/SKAP-HOM (Montrer SKAP2 Anticorps) and SLP-76/Vav (Montrer VAV1 Anticorps)/PLCgamma2 (Montrer PLCG2 Anticorps) signaling hubs may be critical for Yersinia survival.
analysis of a costimulatory mechanism by which CXCL12 (Montrer CXCL12 Anticorps) and antigen converge at SLP-76 microcluster formation to enhance T cell responses
Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI (Montrer FCER1A Anticorps) and the IL-3 (Montrer IL-3 Anticorps) receptor.
a previously unappreciated role for PLC-gamma1 (Montrer PLCG1 Anticorps) in the positive regulation of Zap-70 (Montrer ZAP70 Anticorps) and T-cell receptor tyrosine phosphorylation. Conversely, PLC-gamma1 (Montrer PLCG1 Anticorps) negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck (Montrer LCK Anticorps) substrate phosphorylation sites within this complex.
These data are consistent with a model in which bivalent recruitment of a GADS (Montrer GRAP2 Anticorps)/SLP-76 complex is required for costimulation by CD6 (Montrer CD6 Anticorps).
LAT (Montrer ORC3 Anticorps) and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling.
findings identify ACK1 (Montrer TNK2 Anticorps) as a novel SLP-76-associated protein-tyrosine kinase (Montrer EPHA8 Anticorps) that modulates early activation events in T cells.
Data strongly suggest that chemokine (Montrer CCL1 Anticorps)-stimulated associations between Vav1 (Montrer VAV1 Anticorps), SLP-76, and ADAP (Montrer FYB Anticorps) facilitate Rac1 (Montrer RAC1 Anticorps) activation and alpha4beta1-mediated adhesion, whereas Pyk2 (Montrer PTK2B Anticorps) opposes this adhesion by limiting Rac1 (Montrer RAC1 Anticorps) activation.
TSAD (Montrer SH2D2A Anticorps) binds to and co-localizes with Nck (Montrer NCK1 Anticorps). Expression of TSAD (Montrer SH2D2A Anticorps) increases both Nck (Montrer NCK1 Anticorps)-Lck (Montrer LCK Anticorps) and Nck (Montrer NCK1 Anticorps)-SLP-76 interaction in T cells.
immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (Montrer RANGAP1 Anticorps) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (Montrer NFATC1 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) p65 (Montrer GORASP1 Anticorps) nuclear entry in T cells
SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
SH2 domain-containing leukocyte protein of 76 kDa
, SLP-76 tyrosine phosphoprotein
, lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
, 76 kDa tyrosine phosphoprotein
, SH2 domain-containing leukocyte protein of 76kD
, lymphocyte cytosolic protein 2
, tyrosine phosphoprotein slp-76