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anti-Human MALT1 Anticorps:
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Human Monoclonal MALT1 Primary Antibody pour IHC (p), WB - ABIN2475476
Pincus, Kahan, Mittal: A role for cAMP in the preparation of human platelets for the extraction of histocompatibility antigens. dans Immunochemistry 1976
Show all 3 Pubmed References
Mouse (Murine) Polyclonal MALT1 Primary Antibody pour ELISA, WB - ABIN4332478
Rosebeck, Madden, Jin, Gu, Apel, Appert, Hamoudi, Noels, Sagaert, Van Loo, Baens, Du, Lucas, McAllister-Lucas: Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. dans Science (New York, N.Y.) 2011
A missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1) was identified in a family with siblings with IPEX (Montrer FOXP3 Anticorps)-Like Syndrome. MALT1 deficiency should now be considered as a possible cause of IPEX (Montrer FOXP3 Anticorps)-like syndrome associated with immunodeficiency.
Thrombin (Montrer F2 Anticorps)-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD (Montrer CYLD Anticorps) cleavage.
Authors utilized transcriptomic data and experimental evidences to prove that miR (Montrer MLXIP Anticorps)-181d was a novel regulator of NFkappaB (Montrer NFKB1 Anticorps) signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES (Montrer ME1 Anticorps) genes.
Taken together, this present study indicates that miR (Montrer MLXIP Anticorps)-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies.
These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy.
MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14 (Montrer CARD14 Anticorps)-induced cytokine and chemokine (Montrer CCL1 Anticorps) expression in human primary keratinocytes.
results unveil HOIL1 (Montrer RBCK1 Anticorps) as a negative regulator of lymphocyte activation cleaved by MALT1.
CARD14 (Montrer CARD14 Anticorps)/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review]
Psoriasis mutations disrupt CARD14 (Montrer CARD14 Anticorps) autoinhibition promoting BCL10 (Montrer BCL10 Anticorps)-MALT1-dependent NF-kappaB (Montrer NFKB1 Anticorps) activation
Studies indicate that t(11;18)(q21;q21) translocation involves MALT1 (MALT lymphoma translocation protein 1) gene.
Data show that inhibition of the protease activity of MALT1 might be a strategy to treat inflammatory bowel disease and the NLRP3 (Montrer NLRP3 Anticorps) inflammasome and NF-kappaB (Montrer NFKB1 Anticorps) activation are critical components in MALT1 signaling cascades in this disease model.
MALT1 function is required in B cells for germinal center formation.
Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE)
Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)
TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
MALT1-dependent NF-kappaB (Montrer NFKB1 Anticorps) activation is crucial for the development of EGFR (Montrer EGFR Anticorps)-associated solid-tumor progression
By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB (Montrer NFKB1 Anticorps) pathway.
Results demonstrate that MALT1 protease activity plays key roles in both innate and adaptive immune responses, and in regulating immune homeostasis in vivo.
data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK (Montrer CHUK Anticorps) complexes, thereby directing platelet signals to the NF-kappaB (Montrer NFKB1 Anticorps) pathway.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
mucosa associated lymphoid tissue lymphoma translocation gene 1
, mucosa associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1-like
, MALT associated translocation
, MALT lymphoma-associated translocation
, MALT-lymphoma associated translocation
, caspase-like protein
, mucosa-associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog