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Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
PKCvarepsilon directly modulates the Aurora B (Montrer AURKB Protéines)-dependent abscission checkpoint by phosphorylating Aurora B (Montrer AURKB Protéines) at S227. This phosphorylation invokes a switch in Aurora B (Montrer AURKB Protéines) specificity, with increased phosphorylation of a subset of target substrates, including the CPC subunit Borealin (Montrer CDCA8 Protéines).
Results indicate an important role of protein kinase C epsilon (PKCepsilon) in autophagy and as a therapeutic target.
PKC epsilon, activated by DCP (Montrer ACE Protéines)-LA, increases elastin (Montrer ELN Protéines) and fibulin-5 (Montrer FBLN5 Protéines)/DANCE in the extracellular space of cultured fibroblasts by the mechanism independent of transcriptional and translational modulation or inhibition of elastolysis.
The downregulation of mi143 promoted cell proliferation by regulating PKCepsilon in the hepatocellular carcinoma cells.
These results demonstrate the relevance of hepatic diacylglycerol-induced PKCepsilon activation in the pathogenesis of NAFLD-associated hepatic insulin (Montrer INS Protéines) resistance in humans.
Data show that protein kinase C epsilon (PKCepsilon) phosphorylates migration and invasion inhibitory protein (MIIP (Montrer MIIP Protéines)) at Ser303 and promotes its binding to RelA/p65 (Montrer NFkBP65 Protéines), facilitating colorectal cancer metastasis.
NF-kappaB (Montrer NFKB1 Protéines) signaling thus appears to play a critical role in promoting both castration resistance and enzalutamide resistance in PKC (Montrer PRRT2 Protéines)/Twist1 (Montrer TWIST1 Protéines) signaling in prostate cancer.
results imply that an intimate correlation between miR (Montrer MLXIP Protéines)-218-5p and PRKCE/MDR1 axis abnormal expression is a key determinant of gemcitabine tolerance, and suggest a novel miR (Montrer MLXIP Protéines)-218-5p-based clinical intervention target for Gallbladder cancer patients.
Resistin (Montrer RETN Protéines)-associated vascular smooth muscle cell dysfunction and intimal hyperplasia are related to PKCepsilon-dependent Nox activation and ROS (Montrer ROS1 Protéines) generation
Data indicate that sirtuin 5 (SIRT5 (Montrer SIRT5 Protéines)) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon) activation in the brain.
abnormal PKC-epsilon/PKC-delta (Montrer PKCd Protéines) ratio promotes the activation of Drp1 (Montrer CRMP1 Protéines) signalling, caspase (Montrer CASP3 Protéines) cascades and GSK-3beta-dependent mPTP (Montrer PTPN2 Protéines) opening
PKCepsilon deletion in the epidermis resulted in inhibition of UVR-induced Stat3 (Montrer STAT3 Protéines) phosphorylation.
PKCepsilon is a negative regulator of megakaryopoiesis
study establishes that the pseudosubstrate of PKC-epsilon binds phosphatidylinositol 4-phosphate (PI4P), tethering it to the trans-Golgi network (TGN (Montrer TG Protéines)). This TGN (Montrer TG Protéines)-associated pool of PKC-epsilon is necessary for its concentration at the phagocytic cup and Fc [gamma] receptor (FcgammaR)-dependent membrane fusion
that PKC-epsilon activation mediates 1) dysfunction of complexes I and III of the respiratory chain, 2) oxidant production, 3) morphological damage to the kidney, and 4) decreases in renal functions after ischemia
Sstudy provides evidence that PKCepsilon-ALDH2 (Montrer ALDH2 Protéines) pathway positively regulates adipocyte differentiation by regulation of PPARgamma (Montrer PPARG Protéines) transcriptional activity.
Data suggest that PKCe positively regulates beta-catenin (Montrer CTNNB1 Protéines) expression and stabilization in a glycogen synthase kinase 3beta-independent manner; beta-catenin (Montrer CTNNB1 Protéines) exhibits a perinuclear localization pattern in podocytes; however, beta-catenin (Montrer CTNNB1 Protéines) is predominantly localized to nucleus in podocytes from PKCe knockout mice. (PKCe = protein kinase C epsilon)
Results demonstrate that specific inhibition of PKCepsilon reduces ethanol consumption and prolongs ethanol intoxication, support the development of inhibitors of PKCepsilon catalytic activity as a strategy to reduce ethanol consumption, and they demonstrate that the AS- PKCepsilon mouse is a useful tool to study the role of PKCepsilon in behavior.
These data identify PKCepsilon as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury.
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (Montrer NOS3 Protéines) post-translational modification
Differential expression of protein kinase C epsilon and an elevation of [Ca(2 (Montrer CA2 Protéines)+)]i are important for acquisition of luteolytic response to PGF2 alpha
By regulating VEGFR2 (Montrer KDR Protéines) expression and activation, PKC-epsilon expression is critical for activation of Akt (Montrer AKT1 Protéines) and eNOS (Montrer NOS3 Protéines) by VEGF (Montrer VEGFA Protéines) and contributes to VEGF (Montrer VEGFA Protéines)-stimulated Erk (Montrer MAPK1 Protéines) activation, whereas PKC-alpha (Montrer PKCa Protéines) has opposite effects.
Activation of PKC induces the translocation of Nrf2 (Montrer NFE2L2 Protéines) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells
Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha (Montrer HIF1A Protéines)-mediated mechanism.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
protein kinase C epsilon type
, protein kinase C, epsilon
, protein kinase C epsilon type-like
, pkc epsilon
, protein kinase C, eta