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This study uncovers a previously unrecognized role for PKCepsilon in supporting AML cell survival and disease progression by regulating mitochondrial ROS biology and positions mitochondrial redox regulators as potential therapeutic targets in AML
PKCepsilon isoenzyme mediates the inhibitory action of Angiotensin II on slowly activating delayed rectifier K(+) curren and by phosphorylating distinct sites in KCNQ1/KCNE1, cPKC and PKCepsilon isoenzymes produce the contrary regulatory effects on the channel.
A novel PKCepsilon function that promotes cell growth in prostate cancer cells by increasing aerobic glycolysis through crosstalk between PKCepsilon and Smad2/3.
PKCepsilon interacts with Stat3 during Th17 differentiation and its overexpression results in an enhanced expression of Stat3 and pStat3(Ser727); conversely, when PKCepsilon is forcibly downregulated, CD4+ -T cells show lower levels of pStat3(Ser727) expression and defective in vitro expansion into the Th17-lineage.
Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
PKCvarepsilon directly modulates the Aurora B-dependent abscission checkpoint by phosphorylating Aurora B at S227. This phosphorylation invokes a switch in Aurora B specificity, with increased phosphorylation of a subset of target substrates, including the CPC subunit Borealin.
Results indicate an important role of protein kinase C epsilon (PKCepsilon) in autophagy and as a therapeutic target.
PKC epsilon, activated by DCP-LA, increases elastin and fibulin-5/DANCE in the extracellular space of cultured fibroblasts by the mechanism independent of transcriptional and translational modulation or inhibition of elastolysis.
The downregulation of mi143 promoted cell proliferation by regulating PKCepsilon in the hepatocellular carcinoma cells.
These results demonstrate the relevance of hepatic diacylglycerol-induced PKCepsilon activation in the pathogenesis of NAFLD-associated hepatic insulin resistance in humans.
Data show that protein kinase C epsilon (PKCepsilon) phosphorylates migration and invasion inhibitory protein (MIIP) at Ser303 and promotes its binding to RelA/p65, facilitating colorectal cancer metastasis.
NF-kappaB signaling thus appears to play a critical role in promoting both castration resistance and enzalutamide resistance in PKC/Twist1 signaling in prostate cancer.
results imply that an intimate correlation between miR-218-5p and PRKCE/MDR1 axis abnormal expression is a key determinant of gemcitabine tolerance, and suggest a novel miR-218-5p-based clinical intervention target for Gallbladder cancer patients.
Resistin-associated vascular smooth muscle cell dysfunction and intimal hyperplasia are related to PKCepsilon-dependent Nox activation and ROS generation
PKCepsilon is a key upstream mediator in resistin-induced inflammation that may interact synergistically with TLR4 to promote NF-kB activation in macrophages.
protein kinase C-epsilon regulation, phospholipase D1 protects retinal pigment epithelium cells from lipopolysaccharide-induced damage
PKCdelta and PKCepsilon work as a functional couple with opposite roles on thrombopoiesis, and the modulation of their balance strongly impacts platelet production.
Curcumin inhibited phorbol ester-induced membrane translocation of protein kinase C-epsilon (PKCepsilon) mutants, in which the epsilonC1 domain was replaced with alphaC1, but not the protein kinase C-alpha (PKCalpha) mutant in which alphaC1 was replaced with the epsilonC1 domain, suggesting that alphaC1 is a determinant for curcumin's inhibitory effect.
we demonstrate that PKCepsilon cooperates with the loss of the tumor suppressor Pten for the development of prostate cancer in a mouse model. Mechanistic analysis revealed that PKCe overexpression and Pten loss individually and synergistically upregulate the production of the chemokine CXCL13, which involves the transcriptional activation of the CXCL13 gene
These results indicate that PKC promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 and calcium/calmodulin-dependent kinase II and also by inducing expression of PSD-95 and synaptophysin.
results demonstrate the mechanism for the maintenance of the undifferentiated state of embryonic stem cells via the inhibition of the FGF4-PKCzeta-MEK-ERK1/2 pathway by O-GlcNAcylation on PKCzeta.
Data indicate that sirtuin 5 (SIRT5) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon) activation in the brain.
abnormal PKC-epsilon/PKC-delta ratio promotes the activation of Drp1 signalling, caspase cascades and GSK-3beta-dependent mPTP opening
PKCepsilon deletion in the epidermis resulted in inhibition of UVR-induced Stat3 phosphorylation.
PKCepsilon is a negative regulator of megakaryopoiesis
study establishes that the pseudosubstrate of PKC-epsilon binds phosphatidylinositol 4-phosphate (PI4P), tethering it to the trans-Golgi network (TGN). This TGN-associated pool of PKC-epsilon is necessary for its concentration at the phagocytic cup and Fc [gamma] receptor (FcgammaR)-dependent membrane fusion
that PKC-epsilon activation mediates 1) dysfunction of complexes I and III of the respiratory chain, 2) oxidant production, 3) morphological damage to the kidney, and 4) decreases in renal functions after ischemia
Sstudy provides evidence that PKCepsilon-ALDH2 pathway positively regulates adipocyte differentiation by regulation of PPARgamma transcriptional activity.
Data suggest that PKCe positively regulates beta-catenin expression and stabilization in a glycogen synthase kinase 3beta-independent manner; beta-catenin exhibits a perinuclear localization pattern in podocytes; however, beta-catenin is predominantly localized to nucleus in podocytes from PKCe knockout mice. (PKCe = protein kinase C epsilon)
Results demonstrate that specific inhibition of PKCepsilon reduces ethanol consumption and prolongs ethanol intoxication, support the development of inhibitors of PKCepsilon catalytic activity as a strategy to reduce ethanol consumption, and they demonstrate that the AS- PKCepsilon mouse is a useful tool to study the role of PKCepsilon in behavior.
inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling
PKCepsilon signaling in both the nucleus accumbens and central nucleus of the amygdala is a major contributor to binge alcohol drinking and to the genetic propensity to consume excessive amounts of alcohol.
with strain there was significant PKCepsilon translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin, which was quantified on confocal images.
Protein kinase C epsilon phosphorylates the alpha4 nAChR subunit and regulates recovery from receptor desensitization.
PKCepsilon-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
PKCdelta and PKCepsilon have roles in restraining developmental and reactive heart growth
Pathway analysis indicated that monosaccharide metabolism was affected only upon PKCdelta deletion, while isoprenoid biosynthesis was affected in a PKCepsilon-specific manner.
Study demonstrates that PKCalpha, PKCdelta and PKCepsilon isoforms are differentially expressed in particular cellular components of pre-pubertal, pubertal and adult mouse ovarian follicles.
These data identify PKCepsilon as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury.
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification
Differential expression of protein kinase C epsilon and an elevation of [Ca(2+)]i are important for acquisition of luteolytic response to PGF2 alpha
By regulating VEGFR2 expression and activation, PKC-epsilon expression is critical for activation of Akt and eNOS by VEGF and contributes to VEGF-stimulated Erk activation, whereas PKC-alpha has opposite effects.
Activation of PKC induces the translocation of Nrf2 and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells
Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha-mediated mechanism.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
protein kinase C epsilon type
, protein kinase C, epsilon
, protein kinase C epsilon type-like
, pkc epsilon
, protein kinase C, eta