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Human Polyclonal H2AFX Primary Antibody pour ICC, IHC (fro) - ABIN152063
Kaneko, Igarashi, Kataoka, Miura: Heat shock induces phosphorylation of histone H2AX in mammalian cells. dans Biochemical and biophysical research communications 2005
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Human Polyclonal H2AFX Primary Antibody pour ICC, IF - ABIN151847
Masutomi, Possemato, Wong, Currier, Tothova, Manola, Ganesan, Lansdorp, Collins, Hahn: The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. dans Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Polyclonal H2AFX Primary Antibody pour IHC - ABIN966245
Rogakou, Pilch, Orr, Ivanova, Bonner: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. dans The Journal of biological chemistry 1998
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Human Polyclonal H2AFX Primary Antibody pour IHC - ABIN966246
Rogakou, Boon, Redon, Bonner: Megabase chromatin domains involved in DNA double-strand breaks in vivo. dans The Journal of cell biology 1999
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Human Monoclonal H2AFX Primary Antibody pour BI - ABIN1177063
Burma, Chen, Murphy, Kurimasa, Chen: ATM phosphorylates histone H2AX in response to DNA double-strand breaks. dans The Journal of biological chemistry 2001
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Human Monoclonal H2AFX Primary Antibody pour BI, ICS - ABIN1177065
Fernandez-Capetillo, Lee, Nussenzweig, Nussenzweig: H2AX: the histone guardian of the genome. dans DNA repair 2004
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Human Monoclonal H2AFX Primary Antibody pour BI, ICS - ABIN1177064
Kuo, Yang: Gamma-H2AX - a novel biomarker for DNA double-strand breaks. dans In vivo (Athens, Greece) 2008
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Human Polyclonal H2AFX Primary Antibody pour IF, IHC - ABIN362952
Yaneva, Li, Marple, Hasty: Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. dans Nucleic acids research 2005
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Human Monoclonal H2AFX Primary Antibody pour WB - ABIN1882251
Park, Chan, Park, Oettinger, Kwon: DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner. dans Nucleic acids research 2003
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Human Polyclonal H2AFX Primary Antibody pour ICC, IF - ABIN2668325
Kondo, Obitsu, Ohta, Matsunami, Otsuka, Teshima: Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition. dans The Journal of biological chemistry 2010
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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage.
This study confirms that H2AFX variants are associated with an increased risk of BC. The above-reported sequence variants of MRE11 genes may not constitute a risk factor of breast cancer in the Polish population.
gamma-irradiation also decreased the number of cells in the G1 phase, characterized by no interaction between H3S10ph and gammaH2AX.
The topology of clusters of gammaH2AX foci can be categorized depending on the distance to heterochromatin. The here presented new method opens up new possibilities to categorize spatial organization of point patterns by parameterization of topological similarity.
this study suggests that individual and co-expression pattern of nuclear oxidized-PTP and gamma-H2AX might be used as a prognostic marker of gastric carcinoma
Low pH2AX expression is associated with mouth Cancer.
Results show that the H2AX 3'U TR is targeted by miR328 and its expression inhibited in osteosarcoma cells under radiation conditions.
The results propose a model in which Aurora B-mediated H2AX-phosphorylated serine 121 probably provide a platform for Aurora B autoactivation circuitry at centromeres and thus play a pivotal role in proper chromosome segregation.
Data indicate that nuclear H2A histone family, member X protein (gammaH2AX) expression is positively associated with the programmed death-ligand 1 (PD-L1) expression in lung squamous cell carcinoma.
phosphorylated histone H2AX was predictive of disease progression epithelial dysplasia of the oral cavity.
Gamma-H2AX, phosphorylated KAP-1 and 53BP1 play an important role in the repair of heterochromatic radon-induced DNA double-strand breaks.
in a series of human biopsies, non-metastatic SCCs displayed a higher degree of chromosomal alterations and higher expression of the S phase regulator Cyclin E and the DNA damage signal gammaH2AX than the less aggressive, non-squamous, basal cell carcinomas. However, metastatic Squamous cell carcinoma lost the gammaH2AX signal and Cyclin E, or accumulated cytoplasmic Cyclin E.
We found that phosphorylation of histone H2AX on Ser139 (gamma-H2AX), a biomarker of DSBs, and phosphorylation of ATM at Ser1981, Chk2 at Thr68, and p53 at Ser15, part of signaling pathways associated with DSBs, are elevated in these cells.
number of gammaH2AX foci did not significantly change following cardiac MR (median foci per cell pre-MR = 0.11, post-MR = 0.11, p = .90), but the number of 53BP1 foci significantly increased following MR
Study provides evidence that phosphorylated H2AX binds to the promoter of miR-3196 and regulate its expression leading to lung cancer cell apoptosis.
there may not be a link between low level phosphorylation gammaH2AX sites and double-strand DNA breaks in cells exposed to topoisomerase I or II inhibitors
Residual gammaH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells.
miR-24-mediated knockdown of H2AX may be a novel negative regulator of mitochondrial function and insulin signaling.
suggest that pH2AX alone or better in combination with MAP17 may become a novel and valuable prognostic biomarker for patients with laryngeal carcinoma treated with preservation approaches.
The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
In pachytenes immediate colocalisation of gammaH2AX and 53BP1, which participates in non-homologous end-joining repair pathway, was followed by dissociation from the major focal area of gH2AX by 4 h demonstrating ongoing DSB repair. These results confirm the differential radiosensitivity and repair kinetics of DSBs in male germ cells at different stages.
H2AX has a physiologic function in mediating influences of oxidative stress on NRF2-transcriptional targets and behavior
14days of variable stress, but not a single stress exposure, was associated with increased bed nucleus of the stria terminalis levels of gammaH2AX 24h after termination of the stress paradigm. Phosphorylation levels of a pair of kinases associated with the DNA damage response, glycogen synthase kinase 3 beta (GSK3beta) and p38 mitogen-activated protein kinase (MAPK) were also elevated following variable stress.
The expansion of all three waves of H2AX phosphorylation from the leptotene to pachytene stages is regulated by MOF in meiosis.
TSSK6 is required for gammaH2AX formation during spermiogenesis, and also link gammaH2AX to the histone-to-protamine transition and male fertility.
Our data show that gammaH2AFX enrichment extends as far as 9-15 Mb of the annotated genomic sequence of the q-arms of the translocated chromosomal trivalents and that both gammaH2AFX and H3.3 levels are reduced over the X chromosome. Our data are also suggestive of an asymmetry in gammaH2AFX and H3.3 enrichment with a bias toward the non-translocated homolog.
Results suggest activation of H2AX via promoter demethylation in specific populations of basal mammary cells that is induced by a signal from neighboring luminal cells with hyper STAT5 activity.
A report on a role of H2AX in non-homologous end joining that repairs a site-specific chromosomal DNA double strand breaks
The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX formation, and failure to remove H2BK120ub inhibits ATM- and DNAPK-induced gammaH2AX formation.
The authors observe that persistent accumulation of reactive oxygen species, due to a deficient JunD-/Nrf2-antioxidant response, reduces H2AX protein levels. This effect is mediated by an enhanced interaction of H2AX with the E3 ubiquitin ligase RNF168, which is associated with H2AX poly-ubiquitination and promotes its degradation by the proteasome.
TRAF6 and H2AX overexpression and gammaH2AX-mediated HIF1alpha enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha-driven tumorigenesis, glycolysis and metastasis.
The findings highlight specific non-overlapping functions of PARP1 and PARP2 at H2AX-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 in nonhomologous end-joining-deficient cells.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 and 53BP1 were recruited to these sites. H2AX was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX foci formation and DSB repair, whereas H2AX was barely stabilized in response to secondary DSBs, in which gammaH2AX foci were small and DSBs were not efficiently repaired
this study shows that T cells and thyrocytes in a mouse model of thyrocyte hyperplasia has foci of phosphorylated histone protein H2A.X, indicative of cellular senescence
The role of H2AX phosphorylation and H3K56 acetylation on normal stem cell response to radiation
H2AX knockout mice showed cell-autonomous anaemia and erythroid dysplasia, mimicking dyserythropoiesis in MDS.
These data suggest a role for FoxO3a in the maintenance of genome integrity in response to DNA damage that is mediated by H2AX via yet unknown mechanisms.
overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation
These findings suggest a dimerize-then-rearrange model for H2A-H2B dimers.
Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr(16) by Chk1.
H2Ax phosphorylated protein was detected in in parthenogenetically activated, in vitro fertilized and cloned bovine embryos.
In this communication, we present the first evidence that heat shock induces the phosphorylated form of histone H2AX, which is thought to be generated at the chromatin proximal to DSB sites.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
, histone H2A.x
, histone 5 protein 2ax
, histone H2A type 1