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anti-Human LIG1 Anticorps:
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Human Monoclonal LIG1 Primary Antibody pour ICC, IF - ABIN4305490
Wang, Lindsey-Boltz, Sancar, Bambara: Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex. dans The Journal of biological chemistry 2006
Show all 23 Pubmed References
Human Polyclonal LIG1 Primary Antibody pour ELISA, WB - ABIN4305493
Ferrari, Rossi, Arosio, Vindigni, Biamonti, Montecucco: Cell cycle-dependent phosphorylation of human DNA ligase I at the cyclin-dependent kinase sites. dans The Journal of biological chemistry 2003
Cow (Bovine) Monoclonal LIG1 Primary Antibody pour ELISA, IHC - ABIN4305494
Liang, Deng, Nguyen, Zhao, Maulion, Shao, Tischfield: Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. dans Nucleic acids research 2008
The AtLIG1 is an important component of the active DNA demethylation machinery.
LIG1 is required for both single-nucleotide or long-patch base excision repair.
In the study, we show that loss-of-function of the major DNA LIGASE I (AtLIG1) in Arabidopsis thaliana causes maternal effects in the endosperm, which is the seed tissue that nurtures embryo development.
Nuclear or mitochondrial targeting of LIG1 is accomplished through an evolutionarily conserved translation initiation mechanism. [AtLIG1]
DNA ligase 1 functions in both DNA replication and in repair of both ss and dsDNA strand breaks.
single-stranded break repair by human DNA ligase III (Montrer LIG3 Anticorps) isoforms reveal biochemical differences from DNA ligase
A histone H3K9-like mimic within LIG1 is methylated by G9a (Montrer EHMT2 Anticorps) and GLP (Montrer RCBTB1 Anticorps) and avidly binds UHRF1 (Montrer UHRF1 Anticorps). Interaction with methylated LIG1 promotes the recruitment of UHRF1 (Montrer UHRF1 Anticorps) to DNA replication sites and is required for DNA methylation (Montrer HELLS Anticorps) maintenance.
The rs156641 polymorphism of DNA ligase 1 (LIG1) was significantly associated with lung cancer risk, whereas no association was found between rs3730931/rs439132/rs20579 polymorphisms and lung cancer.
Data suggest that DNA ligase I (LigI)-deficient 46BR.1G1 cells represent a model to investigate the biological effects of sub-lethal levels of DNA insults.
The LIG1 CC genotype was associated with susceptibility to non-small cell lung cancer, and the AA genotype demonstrated increased radiosensitivity compared to the AC and CC genotypes.
Ppolymorphisms in LIG1 affect its expression and may therefore change its function.
there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women
DNA ligase I also interacts with replication factor C, the factor that loads the PCNA (Montrer PCNA Anticorps) trimeric ring onto DNA.
Data indicate that Ku70 (Montrer XRCC6 Anticorps)/Ku80 (Montrer XRCC5 Anticorps) facilitates the cooperative binding of multiple XRCC4 (Montrer XRCC4 Anticorps)/Ligase IV (XL) and XLF (Montrer NHEJ1 Anticorps) molecules to DNA.
Single nucleotide polymorphisms in LIG1 are associated with myelodysplastic syndromes.
Increased presynaptic glutamate (Montrer GRIN1 Anticorps) release is a key early event resulting from Lgi1 (Montrer LGI1 Anticorps)-deficiency, which likely contributes to epileptogenesis.
Lig1 (Montrer Lrig1 Anticorps) is not absolutely required for cellular DNA replication and repair in Lig1 (Montrer Lrig1 Anticorps)-null cell line.
LigI has a highly specific role in CTG repeat maintenance in the maternal germline, involved in mediating CTG expansions and in the avoidance of maternal CTG contractions.
DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
DNA ligase 1
, polydeoxyribonucleotide synthase [ATP] 1
, DNA ligase (ATP) 1
, DNA ligase I
, LIG1, ligase I, DNA, ATP-dependent