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Human Monoclonal POLD1 Primary Antibody pour WB - ABIN151923
Kundu, Balusu, Jaiswal, Narayan: Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways. dans Carcinogenesis 2007
Show all 3 Pubmed References
DNA polymerase delta catalytic subunit controls noncentrosomal gammaTuRC activity and regulates the organization of Golgi-derived microtubules.
POLH (Montrer POLH Anticorps) & POLK (Montrer PAPD7 Anticorps) are both able to exchange with PolD1 stalled at repetitive CFS (common fragile sites) sequences. POLD1 synthesis was inhibited by replication stress caused by aphidicolin, preventing any replication past CFS. Importantly, POLH (Montrer POLH Anticorps) & POLK (Montrer PAPD7 Anticorps) were still proficient in rescuing this stalled POLD1 synthesis. POLD1 stalling at CFSs allows for free exchange with specialized polymerase that is not driven by PCNA (Montrer PCNA Anticorps).
To our knowledge, the four Valencian families included in the present study are the only families where the POLD1 Leu474Pro mutation has been found.
We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2 (Montrer BRCA2 Anticorps)], rs1805389 [ LIG4 (Montrer LIG4 Anticorps)], rs8079544 [ TP53 (Montrer TP53 Anticorps)], rs25489 [ XRCC1 (Montrer XRCC1 Anticorps)], rs1673041 [ POLD1], and rs11615 [ ERCC1 (Montrer ERCC1 Anticorps)]) and subsequent CNS tumors in survivors of childhood cancer treated by radiation therapy.
The proofreading activity of DNA polymerase delta plays a role in shunting DNA mismatch repair to an EXO1 (Montrer EXO1 Anticorps)-dependent excision pathway as opposed to directly participating in gap formation via its 3'-5' exonuclease (Montrer EXOSC10 Anticorps) activity.
Frameshift mutation in POLD1 gene is associated with mismatch repair-deficiency and Lynch syndrome.
the pathogenic role of the POLD1-R689W mutation in the development of the human tumor and emphasize the need to experimentally determine the significance of Poldelta variants present in sporadic tumors.
Our work highlights that mutations in different POLD1 domains can lead to phenotypic variability, ranging from dominantly inherited cancer predisposition syndromes, to mild MDPL phenotypes
Germline or somatic variants in the POLE/POLD1 were identified in unresolved suspected Lynch syndrome cancers with mismatch repair defect.
WRN (Montrer RECQL2 Anticorps) or the Bloom syndrome helicase (BLM (Montrer BLM Anticorps)) stimulates DNA polymerase delta progression across telomeric G-rich repeats, only WRN (Montrer RECQL2 Anticorps) promotes sequential strand displacement synthesis and FEN1 (Montrer FEN1 Anticorps) cleavage.
in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription
reducing expression of individual PRMT7 (Montrer PRMT7 Anticorps) target DNA repair genes showed that only the catalytic subunit of DNA polymerase (Montrer POLB Anticorps), POLD1, was able to resensitize PRMT7 (Montrer PRMT7 Anticorps) knock-down cells to DNA-damaging agents.
A point mutation (D400A) in the proofreading domain of DNA polymerase delta, encoded by the Pold1 gene, inactivates the 3' --> 5' exonuclease (Montrer EXOSC10 Anticorps) of poldelta and causes a mutator and epithelial cancer phenotype in a recessive manner.
Heterozygous mutation at L604 in the polymerase active site of DNA polymerase delta reduces life span, increases genomic instability, and accelerates tumorigenesis in an allele-specific manner, novel findings that have implications for human cancer.
DNA polymerase delta is essential for mammalian early embryogenesis, and the 3'-5' exonuclease (Montrer EXOSC10 Anticorps) activity of DNA polymerase delta is dispensable for normal development but necessary to suppress tumorigenesis
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
, DNA polymerase delta catalytic subunit
, DNA polymerase subunit delta p125
, polymerase (DNA directed), delta 1, catalytic subunit 125kDa
, DNA polymerase delta
, DNA polymerase-delta
, lethal (3) 72Ac
, DNA-directed DNA polymerase delta 1
, DNA polymerase delta catalytic subunit-like
, DNA polymerase delta 1, catalytic domain
, DNA polymerase delta, catalytic subunit
, DNA-dependent DNA polymerase
, DAN polymerase delta 1, catalytic subunit
, polymerase (DNA directed), delta 1, catalytic subunit
, DNA polymerase delta1 catalytic subunit
, flat head