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anti-Human TERT Anticorps:
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Human Monoclonal TERT Primary Antibody pour ICC, FACS - ABIN151783
Masutomi, Yu, Khurts, Ben-Porath, Currier, Metz, Brooks, Kaneko, Murakami, DeCaprio, Weinberg, Stewart, Hahn: Telomerase maintains telomere structure in normal human cells. dans Cell 2003
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Human Monoclonal TERT Primary Antibody pour FACS, ICC - ABIN151763
Zhang, Eguchi, Kruse, Gomez, Fakhrai, Schroter, Ma, Hoa, Minev, Delgado, Wepsic, Okada, Jadus: Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2007
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Dog (Canine) Polyclonal TERT Primary Antibody pour ICC, IF - ABIN265626
Walshe, Harkin: Serial explant culture provides novel insights into the potential location and phenotype of corneal endothelial progenitor cells. dans Experimental eye research 2014
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Human Polyclonal TERT Primary Antibody pour IF (cc), IF (p) - ABIN686167
Gao, Zhao, Song, Yang: Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs. dans Molecular biology reports 2012
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Human Polyclonal TERT Primary Antibody pour DB, IF - ABIN390002
Radan, Hughes, Teichroeb, Vieira Zamora, Jewer, Postovit, Betts: Microenvironmental regulation of telomerase isoforms in human embryonic stem cells. dans Stem cells and development 2014
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Mouse (Murine) Polyclonal TERT Primary Antibody pour WB - ABIN3043095
Qiu, Li, Sui, Sun, Huang, Si, Ge: Immunization with truncated sequence of Telomerase Reverse Transcriptase induces a specific antitumor response in vivo. dans Acta oncologica (Stockholm, Sweden) 2007
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Human Polyclonal TERT Primary Antibody pour FACS, IF - ABIN388165
Sekaric, Cherry, Androphy: Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT. dans Journal of virology 2007
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These data suggest that TERT promoter mutations contribute to tumorigenesis by promoting immortalization and genomic instability in two phases.
Our data suggest that Kras mutations increase telomerase activity and telomere length by activating the RAS/MEK (Montrer MAP2K1 Anticorps) pathway, which contributes to an aggressive phenotype of NSCLC.
mutations in TERT promoter disclose the significance of both nuclear and cytoplasmic TERT in HCC (Montrer FAM126A Anticorps). Cytoplasmic TERT should also be considered when determining prognosis and treatment of HCCs (Montrer HCCS Anticorps).
expression of TERT does not differ in neoplastic and nonneoplastic pituitary tissues
TERT mutations may be associated with shorter survival of glioma patients.
We demonstrate that mature HCV core protein of 173 amino acids, but not the full-length form of 191 amino acids, can suppress miR (Montrer MLXIP Anticorps)-138 expression. TERT can be a direct target of miR (Montrer MLXIP Anticorps)-138 in hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) cells. Further, TERT-targeting miR (Montrer MLXIP Anticorps)-138 supplementation can prevent HCV core protein from repressing HCC (Montrer FAM126A Anticorps) cell replicative senescence.
We may conclude that hTERT promotes GIM by up-regulating CDX2 (Montrer CDX2 Anticorps) via NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway.
Our study indicates that TERT rs2853676 polymorphisms correlate with glioma survival and recurrence rates in a Chinese population, which suggests that they could potentially serve as prognostic markers in glioma patients.
Tianshengyuan-1 induced hypomethylation within TERT core promoter in HL60 cells but induced hypermethylation within TERT core promoter in normal peripheral blood mononuclear cells and CD34 (Montrer CD34 Anticorps)+ hematopoietic stem cells.
pediatric papillary thyroid carcinomas in Japan are characterized by more advanced clinicopathological features, lower BRAF (Montrer BRAF Anticorps) (V600E) frequency, and absence of TERT mutation
The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (Montrer TP53 Anticorps)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomere shortening is more rapid in fas (Montrer FASN Anticorps) tert double mutants than in fas1 (Montrer FAS Anticorps), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (Montrer POT1 Anticorps) protein, POT1A (Montrer POT1 Anticorps) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (Montrer DKC1 Anticorps) associates with active telomerase RNP (Montrer RNPC3 Anticorps) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.
Nrf2 (Montrer NFE2L2 Anticorps)-driven TERT regulates pentose phosphate pathway in glioblastoma.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (Montrer E2F1 Anticorps) target gene expression in smooth muscle cells.
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (Montrer MYC Anticorps), Cyc (Montrer CYCS Anticorps)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a (Montrer WNT10A Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins (Montrer INS Anticorps)-i1[1-102] (Insi1 for short) and Del-e12 (Montrer ELSPBP1 Anticorps)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (Montrer MLXIP Anticorps)-29a-ITGB1 (Montrer ITGB1 Anticorps) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (Montrer NFKB1 Anticorps) signaling, but has limited effect on M2 macrophages polarization in vitro.
TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signalling pathway
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
telomerase catalytic subunit
, telomerase-associated protein 2
, Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, telomerase reverse transcriptase beta
, Telomerase catalytic subunit