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anti-Human TERT Anticorps:
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Human Polyclonal TERT Primary Antibody pour ELISA, FM - ABIN6655270
Gizard, Heywood, Findeisen, Zhao, Jones, Cudejko, Post, Staels, Bruemmer: Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages. dans Arteriosclerosis, thrombosis, and vascular biology 2011
Show all 19 Pubmed References
Human Monoclonal TERT Primary Antibody pour ICC, FACS - ABIN151783
Masutomi, Yu, Khurts, Ben-Porath, Currier, Metz, Brooks, Kaneko, Murakami, DeCaprio, Weinberg, Stewart, Hahn: Telomerase maintains telomere structure in normal human cells. dans Cell 2003
Show all 20 Pubmed References
Human Monoclonal TERT Primary Antibody pour FACS, ICC - ABIN151763
Zhang, Eguchi, Kruse, Gomez, Fakhrai, Schroter, Ma, Hoa, Minev, Delgado, Wepsic, Okada, Jadus: Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2007
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Dog (Canine) Polyclonal TERT Primary Antibody pour ICC, IF - ABIN265626
Walshe, Harkin: Serial explant culture provides novel insights into the potential location and phenotype of corneal endothelial progenitor cells. dans Experimental eye research 2014
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Monoclonal TERT Primary Antibody pour IF, WB - ABIN534102
Masutomi, Possemato, Wong, Currier, Tothova, Manola, Ganesan, Lansdorp, Collins, Hahn: The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. dans Proceedings of the National Academy of Sciences of the United States of America 2005
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Mouse (Murine) Polyclonal TERT Primary Antibody pour WB - ABIN3043095
Qiu, Li, Sui, Sun, Huang, Si, Ge: Immunization with truncated sequence of Telomerase Reverse Transcriptase induces a specific antitumor response in vivo. dans Acta oncologica (Stockholm, Sweden) 2007
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Human Polyclonal TERT Primary Antibody pour DB, ELISA - ABIN545856
Sekaric, Cherry, Androphy: Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT. dans Journal of virology 2007
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Human Polyclonal TERT Primary Antibody pour ELISA, WB - ABIN543452
Okawa, Michaylira, Kalabis, Stairs, Nakagawa, Andl, Johnstone, Klein-Szanto, El-Deiry, Cukierman, Herlyn, Rustgi et al.: The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and ... dans Genes & development 2007
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Human Polyclonal TERT Primary Antibody pour ELISA, ICC - ABIN6266278
Zhang, Chen, Wang, Yang, Li, Wang, Liu, Ye: Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase. dans Oncotarget 2018
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Human Polyclonal TERT Primary Antibody pour IF (cc), IF (p) - ABIN686167
Gao, Zhao, Song, Yang: Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs. dans Molecular biology reports 2012
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TERT knockdown significantly contributes to the efficacy of HNSCC treatment.
hTERT expression was negative in 93 (67.4%) and positive in 45 (32.6%) patients. Twenty-three (46.0%) of 50 PC, 12 (36.0%) of 33 FA, 1 (10.0%) of 10 FC, 4 (13.0%) of 31 MNG, 2 (66.0%) of 3 medullary carcinoma (MC) patients were found hTERT (+), showing that the difference between PC and FC was significant (p=0.034).
hTERTN mRNA levels in urine were higher in patients with bladder tumors compared to patients with a history of bladder tumor and with negative cystoscopy, as well as in the control group. This determination showed a higher diagnostic yield compared with the detection of NMP22 and urinary cytology
rs4402960 (IGF2BP2) and rs2736098 (TERT) are identified as independent risk factors for type 2 diabetes. The simultaneous presence of both risk alleles confers a three-fold increased risk of developing the disease.
TERT promoter mutation is associated with in-situ melanomas.
These data suggest that hTERT promoter mutations are common in high grade conventional chondrosarcomas.
HTERT promoter methylation and single nucleotide polymorphism is associated with renal cell carcinoma.
TERT promoter mutation is associated with metastatic medulloblastoma.
The K902N and R631Q mutations might stop the catalytic activity preventing the exit of the pyrophosphate from the catalytic pocket. Additionally, evidence that the same mechanism probably applies to the K626A, R631A, and K902A mutations is presented.
hTERT splicing occurs both in glioma cell lines and glioma patients' tissues. The telomerase activity was related to the expression level of the full-length hTERT, rather than the total hTERT transcript level. AON-Ex726 was complementary to the sequence of the intronic splicing enhancer (ISE) in intron six, and significantly altered the splicing pattern of hTERT pre-mRNA.
TERT promoter mutations are associated with cancer.
Results showed both in retinoid-treated cell lines and in acute promyelocytic leukemia (APL) patient cells an inverse relationship between the expression of H19 and the expression and activity of hTERT. Exploring the mechanistic link between H19 and hTERT regulation, data showed that H19 is able to impede telomerase function by disruption of the hTERT-hTR interaction.
Either inhibition of telomerase by BIBR 1532 or AR blockages by enzalutamide decreased prostate-specific antigen (PSA) and the catalytic component of telomerase, hTERT, expression. These results suggest that telomerase inhibition therapy may contribute to the efficacy of enzalutamide in the androgen-sensitive prostate cancer model.
Xenobiotic Response Elements (XREs) from Human CYP1A1 Gene Enhance the hTERT Promoter Activity.
the presence of a TERT promoter mutation in meningioma can be associated with worse prognosis, and shorter overall survival (Systematic Review)
TERT promoter mutation proved an independent predictor of distant metastases in patients with follicular-derived thyroid cancers.
Our results indicate that hotspot TERT promoter mutation status may be a useful ancillary parameter for the diagnosis of melanoma
Lower PFKFB2 methylation levels was an independent factor of high relapse risk (Hazard Ratio = 3.2; CI95% = 1.19.5). PFKFB2 promoter methylation analysis has potential applicability to better stratify well-differentiated thyroid carcinomas (WDTC) patients according to the recurrence risk, independently of BRAF and TERT mutations.
hTERT expression correlates with the cytological grade of the cervical lesions and HPV infection status.
This study revealed a dynamic hTERT regulation by chromatin environment and promoter-bound transcription factors during embryonic stem cell differentiation.
The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.
Telomerase may be required to prevent or repair sporadic telomere truncations that are unrelated to the typical 'end-replication' problems.
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
Ectopic expression of human telomerase RNA component results in increased telomerase activity and elongated telomeres in bovine blastocysts.
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase is essential for heart muscle regeneration in zebrafish.
Telomerase-deficient zebrafish show p53-dependent premature aging and reduced lifespan in the first generation.
Thus, telomerase is limiting for zebrafish lifespan, enabling the study of telomere shortening in naturally ageing individuals.
a direct relationship between the expression of telomerase, telomere length and the efficiency of tissue regeneration
telomerase expression and telomere length are unaffected by either age or limb regeneration in Danio rerio
Role of telomerase in vertebrate central nervous system (CNS) other than telomere maintenance, such as regulation of cell cycle progression and maintenance of retinal cell phenotypes.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomere shortening is more rapid in fas tert double mutants than in fas1, fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 protein, POT1A (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 associates with active telomerase RNP particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Results indicate that the architecture for the vertebrate telomerase RNA (TR) template/pseudoknot (t/PK) is conserved from teleost fish to human.
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
Telomerase contributes to lymphocyte proliferation but plays no major role in Treg function, provided that telomere length is not critically short. Oxidative stress may contribute to atherosclerosis via suppression of telomerase and acceleration of telomere attrition in Tregs.
Data show that snail family zinc finger 1 (Snail1)-deficient mesenchymal stem cells (MSC) present higher levels of both telomerase activity and the long non-coding RNA called telomeric repeat-containing RNA (TERRA), an RNA that controls telomere integrity.
Par-4 activation and binding to TERT are key steps required for inducing the apoptosis of islet beta cells under high-glucose/fatty acid conditions in type 2 diabetes.
Tert-deficient but not Terc-deficient mice develop hepatocyte injury and frank steatosis when challenged with liquid high-fat diet.
identification of a subset of hepatocytes that expresses high levels of telomerase and show that this hepatocyte subset repopulates the liver during homeostasis and injury
These preclinical data in mouse models and human cells provide a strong rationale for the development of pharmacological approaches to target BMI1-mediated mitochondrial regulation and protection from DNA damage to sustain the regenerative potential of the skeletal muscle in conditions of chronic muscle wasting.
Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.
Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc, Cyc-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a/beta-catenin signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins-i1[1-102] (Insi1 for short) and Del-e12[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR-29a-ITGB1 regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB signaling, but has limited effect on M2 macrophages polarization in vitro.
The results suggest that the mouse endometrial epithelium and vasculature are foci of stem/progenitor activity expressing mTert.
miR-195 overexpressed in old mesenchymal stem cells (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging.
These findings indicate that telomerase gene therapy represents a novel therapeutic strategy to treat aplastic anemia provoked or associated with short telomeres.
TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt/beta-catenin signalling pathway
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
telomerase catalytic subunit
, telomerase-associated protein 2
, Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, telomerase reverse transcriptase beta
, Telomerase catalytic subunit