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Human Transcription Termination Factor, RNA Polymerase I (TTF1) interaction partners

1. TTF1 expression is an independent predictor of survival of patients with advanced lung adenocarcinoma

2. the TTF-1 protein and mRNA are specifically expressed in schwannomas

3. Human TTF-I localizes in the nucleolus and N-terminus (1-224) of hTTF-I which include nucleolus localization sequence and the expression of Human TTF-I 521-732 increased HIV-I production by regulating transactivation of the LTR promoter.

4. These findings collectively suggest that the triple combination of survivin knockdown with ABT-263 and trametinib treatment, may be a potential strategy for the treatment of KRAS-mutant lung adenocarcinoma. Furthermore, our findings indicate that the welldifferentiated type of KRAS-mutant lung tumors depends, at least in part, on TTF1 for growth.

5. TTF-1 expression may serve as a predictive marker to identify lung cancer patients who may benefit from the addition of bevacizumab to platinum doublet therapy.

6. Our results showed that an approach of using only a two-antibody panel (p40 and TTF-1) might help in reduction of diagnostic category of NSCLC-NOS significantly and contribute in saving tissue for future molecular testing

7. Single nucleotide polymorphism in TTF1 gene is associated with Systemic lupus erythematosus

8. Case Report: KRAS mutation-positive bronchial surface epithelium type lung adenocarcinoma with strong expression of TTF-1.

9. Overexpression of Transcription Termination Factor 1 is Associated with Colorectal Cancer

10. Depletion of TTF-I recapitulates the effects of ARF on ribosomal RNA synthesis and is rescued by the introduction of a TTF-I transgene.

Mouse (Murine) Transcription Termination Factor, RNA Polymerase I (TTF1) interaction partners

1. Together with results showing involvement of TTF-1 in the TNF-alpha-induced increase in interleukin 1 beta and monocyte chemotactic protein 1 production, this study suggests that TTF-1 plays an important role in the mouse hypothalamus TNF-alpha-induced inflammatory response for regulating HO-1 gene expression.

2. this study shows that in a mouse model of thyrocyte hyperplasia, proliferating thyrocytes were thyroid transcription factor (TTF1)-positive

3. TTF-1 is expressed in lung during different stages of development.

4. Interaction of TTF-I with target sites upstream and downstream of the rDNA transcription unit connects these distal DNA elements by forming a chromatin loop between the rDNA promoter and the terminators.

5. ErbB4 is a critical upstream regulator of TTF-1 in type II epithelial cells and that this interaction is important for Sftpb regulation.

6. Otp and TTF-1 are essential for the normal morphological development of the hypothalamus, including the arcuate nucleus [review]

7. Depletion of TTF-I recapitulates the effects of ARF on ribosomal RNA synthesis and is rescued by the introduction of a TTF-I transgene.

8. Mediates interaction between promoter and terminator regions, which brings the beginning and end of active ribosomal RNA genes into close contact.

Cow (Bovine) Transcription Termination Factor, RNA Polymerase I (TTF1) interaction partners

1. Ribosomal RNA is maternally inherited and target to DNA independent of transcription, and de novo transcription is required for proper nucleologenesis in cattle.