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anti-Human TTF2 Anticorps:
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replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation
The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to papillary thyroid carcinoma, while a contributing role of the FOXE1 (Montrer FOXE1 Anticorps) poly-Ala polymorphism could not be confirmed.
FOXE1 (Montrer FOXE1 Anticorps) interacts with ELK1 (Montrer ELK1 Anticorps) on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT (Montrer TERT Anticorps) suggests a mechanism by which allelic variants in/near FOXE1 (Montrer FOXE1 Anticorps) are associated with thyroid cancer risk.
In a Cuban population, differentiated thyroid cancer risk was positively and strongly associated with the number of copies in the minor allele (A) for SNP rs965513 near FOXE1 (Montrer FOXE1 Anticorps) among people who consumed less iodine than the median.
methylation-mediated silencing of FOXE1 (Montrer FOXE1 Anticorps) expression may contribute to the progression of CRC (Montrer CALR Anticorps).
Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
We identified a FOXE1 (Montrer FOXE1 Anticorps): c.532_537delGCCGCC p.(Ala178_Ala179del) variant that predisposes to thyroid ectopia. Taken together, this is the first report of mosaic 11p13 deletion in association with thyroid dysgenesis
Our results implicate FOXE1 (Montrer FOXE1 Anticorps) as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting.
FOXE1 (Montrer FOXE1 Anticorps) polyalanine repeat polymorphisms are associated with thyroid cancer, but only for tumours larger than 1 cm, suggesting a role in disease progression.
In the analysis of all OFCs combined, SNPs near FOXE1 (Montrer FOXE1 Anticorps) reached genome-wide significance
Overexpression of TTF-2 during the palatogenesis may contribute to cleft palate.
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
, RNA polymerase II termination factor
, human factor 2
, lodestar homolog
, lodestar protein
, transcription release factor 2
, transcription termination factor 2
, transcription termination factor, RNA polymerase II
, transcription termination factor 2-like