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Mouse (Murine) Polyclonal IL17RD Primary Antibody pour CyTOF, FACS - ABIN4900068
Miraoui, Dwyer, Sykiotis, Plummer, Chung, Feng, Beenken, Clarke, Pers, Dworzynski, Keefe, Niedziela, Raivio, Crowley, Seminara, Quinton, Hughes, Kumanov, Young, Yialamas, Hall, Van Vliet, Chanoine et al.: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. ... dans American journal of human genetics 2013
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miR (Montrer MLXIP Anticorps)-193a-3p is downregulated in ulcerative colitis neoplasia, and its loss promotes carcinogenesis through upregulation of IL17RD. These findings provide novel insight into inflammation-driven colorectal cancer and could suggest new therapeutic targets in this high-risk population
Low SEF (Montrer TFCP2 Anticorps) expression is associated with Epithelial-Mesenchymal Transition in Breast Cancer and thus Metastasis in breast Cancer.
Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT (Montrer ITK Anticorps).
IL17RD negatively regulates Toll-like receptor (TLR)-induced responses.
Demonstrate SEF (Montrer TFCP2 Anticorps) expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis.
These results reveal Sef-S actives Lys63-linked TAK1 (Montrer MAP3K7 Anticorps) polyubiquitination on lysine 209, induces TAK1 (Montrer MAP3K7 Anticorps)-mediated JNK (Montrer MAPK8 Anticorps) and p38 (Montrer CRK Anticorps) activation and also results apoptosis in 293T cells.
FGF17 (Montrer FGF17 Anticorps) and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism.
Downregulation of SEF (Montrer TFCP2 Anticorps) mRNA is associated with prostate cancer.
Orphan receptor (Montrer NR1D2 Anticorps) IL-17RD tunes IL-17A (Montrer IL17A Anticorps) signalling and is required for neutrophilia.
Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock.
Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
these studies indicate that Sef has specific roles in osteoblast and osteoclast lineages and that its absence results in increased osteoblast and osteoclast activity with a net increase in cortical bone mass.
Since expression of IL-17 (Montrer IL17A Anticorps) is elevated in 3-month-old MRL/lpr (Montrer FAS Anticorps) mice, we suggest that it plays a role in the pathophysiology of autoimmune dacryoadenitis in these mice.
Over-expressing Sef specifically in the lens of transgenic mice led to impaired lens and eye development that resulted in microphthalmia.
Fgf8 (Montrer FGF8 Anticorps), Spry2 (Montrer SPRY2 Anticorps) and Sef belong to a synexpression group and may functionally interact during mouse embryonic development
Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling
Sef and Sproutys function synergistically to regulate Gbx2 (Montrer GBX2 Anticorps) expression in the anterior hindbrain.
Here we demonstrated that both extracellular and transmembrane domains of Sef contributed to Sef-mediated negative regulation of FGF signaling.
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367).
interleukin 17 receptor D
, interleukin-17 receptor D-like
, IL-17 receptor D
, interleukin-17 receptor D
, interleukin-17 receptor-like protein
, sef homolog
, similar expression to FGF genes protein