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Cow (Bovine) Monoclonal ARF1 Primary Antibody pour ICC, FACS - ABIN152664
Lu, Horstmann, Ng, Hong: Regulation of Golgi structure and function by ARF-like protein 1 (Arl1). dans Journal of cell science 2002
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Arabidopsis thaliana Polyclonal ARF1 Primary Antibody pour IF, WB - ABIN2688655
Pimpl, Movafeghi, Coughlan, Denecke, Hillmer, Robinson: In situ localization and in vitro induction of plant COPI-coated vesicles. dans The Plant cell 2001
Show all 8 Pubmed References
The zebrafish-metastasis model confirms that the ARF1 gene depletion suppresses breast cancer cells to metastatic disseminate throughout fish body.
ARF1 is a critical regulator in prostate cancer progression
our findings demonstrate that ARF1 is a molecular switch for cancer progression and thus suggest that limiting the expression/activation of this GTPase (Montrer RACGAP1 Anticorps) could help improve outcome for breast cancer patients.
changes in distinct lipid ratios may converge on ARF1 to increase SBP-1 (Montrer MEGF8 Anticorps)/SREBP-1 (Montrer SREBF1 Anticorps) activity.
Experiments using a mutant form of ARF1 affecting GTP (Montrer AK3 Anticorps) hydrolysis suggest that ARF1[GTP (Montrer AK3 Anticorps)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (Montrer PLIN2 Anticorps) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (Montrer PLIN2 Anticorps) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
ARF1 may reverse CAM-DR by regulating phosphorylation of p27 (Montrer PAK2 Anticorps) at T157 in MM. our data shed new light on the molecular mechanism of CAM-DR in MM, and targeting ARF1 may be a novel therapeutic approach for improving the effectiveness of chemotherapy in MM.
We report here that 2-methylcoprophilinamide (M-COPA (Montrer COPA Anticorps)), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), suppresses Stx (Montrer ST8SIA2 Anticorps)-induced apoptosis. M-COPA (Montrer COPA Anticorps) inhibited transport of Stx (Montrer ST8SIA2 Anticorps) from the plasma membrane to the Golgi apparatus and suppressed degradation of anti-apoptotic proteins and the activation of caspases
observations indicate that Arf1 and Arf3 (Montrer ARF3 Anticorps) as well as Arf6 (Montrer ARF6 Anticorps) play important roles in cytokinesis.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a, Arf1 and p53 (Montrer TP53 Anticorps) delays age-associated central nervous system functional decline.
ARF1/TBCE (Montrer TBCE Anticorps)-mediated cross-talk that coordinates COPI formation and tubulin (Montrer TUBB Anticorps) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf modulates LRP6 (Montrer LRP6 Anticorps) phosphorylation for the transduction of Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
termination of Arf1 signals mediated through GGA require that Arf1.GTP (Montrer AK3 Anticorps) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (Montrer AK3 Anticorps)
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (Montrer NCS1 Anticorps) in mitochondrial function via its association with several mitochondrial proteins.
Vascular endothelial growth factor receptor-2 (Montrer KDR Anticorps) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (Montrer NOS3 Anticorps) activation and nitric oxide release from endothelial cells
Data show that AP-1 (Montrer JUN Anticorps) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (Montrer AK3 Anticorps) or nonhydrolyzable GTP (Montrer AK3 Anticorps)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (Montrer NCS1 Anticorps)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (Montrer CA2 Anticorps)+)-dependent and ARF-dependent pathways in TGN (Montrer TG Anticorps) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (Montrer JUN Anticorps) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (Montrer AK3 Anticorps).
Study shows that ARF DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (Montrer ARF5 Anticorps)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (Montrer ARF5 Anticorps) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP-ribosylation factor 1
, adp-ribosylation factor 1
, ADP-ribosylation factor domain protein 1