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anti-Mouse (Murine) IREB2 Anticorps:
anti-Rat (Rattus) IREB2 Anticorps:
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Mouse (Murine) Polyclonal IREB2 Primary Antibody pour GS, ICC - ABIN151305
Regan, Chen, Li, Zhang, Benvenisti-Zarom, Chen-Roetling: Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. dans Neurobiology of disease 2008
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Human Polyclonal IREB2 Primary Antibody pour ICC, IF - ABIN151304
Maeda, Hasegawa, Hyodo, Ito, Asano, Yuang, Funasaka, Shimokata, Hasegawa, Hamaguchi, Senga: ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. dans Molecular biology of the cell 2011
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Human Polyclonal IREB2 Primary Antibody pour ELISA, IHC - ABIN4327648
Wang, Di, DAgostino, Torti, Torti: Excess capacity of the iron regulatory protein system. dans The Journal of biological chemistry 2007
The Irp2(-/-) mice develop microcytic anemia, erythropoietic protoporphyria (Montrer FECH Anticorps) and a progressive neurological disorder, indicating that Irp2 has important functions in the nervous system and erythropoietic homeostasis
Irp2 mRNA transcription is promoted by circadian clock genes, including BMAL1 (Montrer ARNTL Anticorps), and the CLOCK heterodimer.
Irp2 increased mitochondrial iron loading and levels of cytochrome c oxidase, which led to mitochondrial dysfunction and subsequent experimental COPD.
IRP1 (Montrer ACO1 Anticorps) and IRP2 mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.
aged Irp2-/- mice show marked iron deposition in white matter and in oligodendrocytes while iron content is significantly reduced in neurons. mice show impairments in locomotion, exploration, motor coordination/balance and nociception .
misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy
A wide network of mRNAs and proteins with iron-dependent regulation, IRP (Montrer WNT2 Anticorps)-dependent regulation, or both.
The FBXL5 (Montrer FBXL5 Anticorps)-IRP2 axis is integral to control of iron metabolism in vivo.
Iron regulatory protein 1 (Montrer ACO1 Anticorps) outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.
Mice lacking both IRP2 in their hepatocytes suffer from mitochondrial iron deficiency and dysfunction associated with alterations of the ISC and heme biosynthetic pathways, leading to liver failure and death.
Five of these SNPs acted as cis (Montrer CISH Anticorps)-eQTLs, being associated with the transcription of IREB2 (rs2568494, rs16969968, rs11634351, rs6495309), PSMA4 (Montrer PSMA4 Anticorps) (rs6495309) and ERCC1 (Montrer ERCC1 Anticorps) (rs735482), out of 10,821 genes analyzed in lung. For these three genes, we obtained experimental evidence of differential allelic expression in lung tissue, pointing to the existence of in-cis (Montrer CISH Anticorps) genomic variants that regulate their transcription.
Iron loading caused cell proliferation in cancer cell lines, which were less able to regulate IREB2 expression than primary bronchial epithelial cells (PBECs). Iron chelation resulted in a return of proliferation rates to baseline levels; knockdown of IREB2 had a similar effect. IRP2-positive tumours were larger and higher percentage staining related to poorer survival.
The rs13180 (IREB2), rs16969968 (CHRNA5 (Montrer CHRNA5 Anticorps)) and rs1051730 (CHRNA3 (Montrer CHRNA3 Anticorps)) were significantly associated with Chronic obstructive pulmonary disease (COPD (Montrer ARCN1 Anticorps)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (Montrer ARCN1 Anticorps) in our population (Padj =0.0005, OR=0.61).
IRP2 expression was associated with mutations in BRAF (Montrer BRAF Anticorps).
The current results revealed that there was significant association between IREB2 gene rs2568494 polymorphism with susceptibility to Chronic Obstructive Pulmonary Disease.
This study confirms that the IREB2 variants contribute to an increased risk of lung cancer, whereas FAM13A predisposes to increased susceptibility to chronic obstructive pulmonary disease.
IREB2 - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies.
Irp2 expression is increased in airway epithelial cells exposed to cigarette smoke.
IRP2 can regulate the expression of TfR (Montrer TFRC Anticorps) and Fn by changing its own protein expression and thereby regulate iron metabolism.
Genetic variants near IREB2 and GALC (Montrer GALC Anticorps) likely contribute to genetic susceptibility to PAE associated with COPD (Montrer ARCN1 Anticorps).
RNA-binding proteins that bind iron-responsive elements (IREs)
iron-responsive element binding protein 2
, iron regulatory protein 2
, Iron-responsive element-binding protein 2
, iron-responsive element-binding protein 2-like
, IRE-BP 2
, iron-responsive element-binding protein 2
, iron-regulatory protein 2