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Human Polyclonal NFS1 Primary Antibody pour WB - ABIN522493
Huang, Becker, Whitnall, Suryo Rahmanto, Ponka, Richardson: Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant. dans Proceedings of the National Academy of Sciences of the United States of America 2009
AtFH binds and modulates Nfs1 kinetics in mitochondria.
NFS1 has a role in mediating the assembly of iron-sulfur clusters in mitochondria.
analysis of the NFS1-ISD11 (Montrer LYRM4 Anticorps)-ACP (Montrer NDUFAB1 Anticorps) (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2 (Montrer ISCU Anticorps), frataxin (FXN (Montrer FXN Anticorps)), and ferredoxin to synthesize Fe-S clusters
NFS1 maintains the iron sulfur clusters in proteins that are essential for protecting them from oxidative damage; inactivating NFS1 or iron sulfur clusters can trigger ferroptosis, a non-apoptotic form of cell death, in cancer cells
human NFS1 was almost fully able to complement the role of IscS in Moco biosynthesis when its specific interaction partner protein MOCS3 (Montrer MOCS3 Anticorps) from humans was also present.
The NFS1/ISD11 (Montrer LYRM4 Anticorps) complex further interacts with scaffold protein (Montrer HOMER1 Anticorps) ISCU (Montrer ISCU Anticorps) and regulator protein frataxin (Montrer FXN Anticorps), thereby forming a quaternary complex for Fe-S cluster formation.
FDX1 (Montrer FDX1 Anticorps) and FDX2 both bind NFS1 and donate electrons for iron-sulfur cluster biosynthesis.
Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (Montrer FXN Anticorps)(42-210)]24.[NFS1]24.[ISD11 (Montrer LYRM4 Anticorps)]24.[ISCU (Montrer ISCU Anticorps)]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.
Our findings highlight that the ISD11 (Montrer LYRM4 Anticorps) R68A/R68L mutation display reduced affinity to form a stable subcomplex with NFS1, and thereby fails to prevent NFS1 aggregation resulting in impairment of the Fe-S cluster biogenesis
The data presented here show that the Isu1 suppressor mimics the frataxin (Montrer FXN Anticorps) effects on Nfs1, explaining the bypassing activity.
NFS1 binds preferentially to the D-state of ISCU (Montrer ISCU Anticorps) while mtHSP70 (Montrer HSPA9 Anticorps) binds preferentially to the D-state of ISCU (Montrer ISCU Anticorps) and HSC20 (Montrer HSCB Anticorps) binds preferentially to the S-state of ISCU (Montrer ISCU Anticorps).
the interaction of NFS1 and MOCS3 (Montrer MOCS3 Anticorps) in the cytosol of human cells, is reported.
there is a mechanism that primarily dedicates m-Nfs1 to the biogenesis of mitochondrial Fe-S clusters in order to maintain cell survival
While IFN-gamma (Montrer IFNG Anticorps) alone induced Nfs1 protein instability, LPS (Montrer TLR4 Anticorps) triggered a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability.
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.
cysteine desulfurase NFS1
, cysteine desulfurase, (m-Nfs1)
, cysteine desulfurase
, NFS1 nitrogen fixation 1 homolog
, cysteine desulfurase, mitochondrial
, nitrogen fixation 1 (S. cerevisiae, homolog)
, nitrogen-fixing bacteria S-like protein
, nitrogen fixation gene 1
, NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
, nifS-like (sic)
, nitrogen fixation gene, yeast homolog 1
, LOW QUALITY PROTEIN: cysteine desulfurase, mitochondrial
, NFS1 nitrogen fixation 1