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Tfr2 is a key regulator of brain iron homeostasis and propose a role for Tfr2 alpha in the regulation of anxiety circuits.
erythroid Tfr2 is essential for an appropriate erythropoietic response in iron-deficient anemia
These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin (Montrer SLC40A1 Anticorps) and thus macrophage iron homeostasis
Tfr2 is a novel target gene for HNF4alpha (Montrer HNF4A Anticorps), and hepatic HNF4alpha (Montrer HNF4A Anticorps) plays a critical role in iron homeostasis.
There is an essential role for TFR2 in erythropoiesis that may provide new targets for the treatment of anaemia.
We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo (Montrer EPO Anticorps) sensitivity.
We propose that TFR2 is a limiting factor for erythropoiesis, particularly in conditions of iron restriction.
These results support in vivo studies which suggest that Hfe (Montrer HFE Anticorps) and Tfr2 can independently regulate hepcidin (Montrer HAMP Anticorps).
we used microarray and real-time reverse transcription polymerase chain reaction to assess brain transcriptome profiles of transferrin receptor 2 mutant mice a model of a rare type of hereditary hemochromatosis (Montrer HFE Anticorps)
Double mutant mice lacking functional Hfe (Montrer HFE Anticorps) or Tfr2 and Tmprss6 (Montrer TMPRSS6 Anticorps) exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 (Montrer TMPRSS6 Anticorps) demonstrating that Hfe (Montrer HFE Anticorps) and Tfr2 are not substrates for Tmprss6 (Montrer TMPRSS6 Anticorps).
In agreement with previous studies with truncated forms of these receptors, holo-Tf binds to the TfR1 (Montrer TFRC Anticorps) homologue significantly stronger than to TfR2.
Authors retrospectively investigated whether TFR2 isoforms and EPOR (Montrer EPOR Anticorps) are differentially expressed in MDS (Montrer PAFAH1B1 Anticorps) patients and whether the expression is associated with patients' clinical outcomes.
unreported iron metabolism-related genes in non-classic hereditary hemochromatosis (Montrer HFE Anticorps) patients that were predicted to be potentially pathogenic were three novel mutations in TFR2 [two missense (p.Leu750Pro and p.Ala777Val) and one intronic splicing mutation (c.967-1G>C)], one missense mutation in HFE (Montrer HFE Anticorps) (p.Tyr230Cys), and one mutation in the 5'-UTR (Montrer UTS2R Anticorps) of HAMP (Montrer HAMP Anticorps) gene (c.-25G>A)
TFR2 expression altered within 4h of HAMP (Montrer HAMP Anticorps) treatment, while HFE (Montrer HFE Anticorps) expression altered later at 24h and 48h, suggesting that TFR2 may function prior to HFE (Montrer HFE Anticorps) in HAMP (Montrer HAMP Anticorps) regulation.
Of the non-HFE (Montrer HFE Anticorps) forms of iron overload, TFR2-, HFE2 (Montrer HFE2 Anticorps)-, and HAMP (Montrer HAMP Anticorps)-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 (Montrer SLC40A1 Anticorps) variants that have been previously associated with autosomal-dominant ferroportin (Montrer SLC40A1 Anticorps) disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
Transferrin (Montrer Tf Anticorps) facilitates the formation of DNA double-strand breaks (DNA-DSBs) via transferrin receptor TfR1 but not TfR2.
In line with a status of iron deficiency, gene expression studies suggested decreased expression of transferrin (Montrer Tf Anticorps) and transferrin receptor 2 in non-alcoholic steatohepatitis livers
Our results indicate that membrane transferrin receptor-2, a sensor of circulating iron, is released from the cell membrane in iron deficiency.
results suggest that down-regulation of CD81 (Montrer CD81 Anticorps) by GRAIL (Montrer RNF128 Anticorps) targets TfR2 for degradation
Polymorphisms of the TRF2 (Montrer TERF2 Anticorps) gene may be associated with age-related macular degeneration occurrence, either directly or by modulation of risk factors.
One novel SNPs was identified in TFR2 which tended to be associated (P < 0.013) with skeletal muscle iron content.
TfR2 is coexpressed with transferrin-a (Montrer Tf Anticorps) in the liver of the zebrafish embryo. Knockdown of TfR2 fails to produce anemia or a morphologic defect.
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
transferrin receptor 2
, transferrin receptor protein 2-like
, transferrin receptor protein 2