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anti-Rat (Rattus) DVL2 Anticorps:
anti-Mouse (Murine) DVL2 Anticorps:
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Cow (Bovine) Polyclonal DVL2 Primary Antibody pour IHC, WB - ABIN2779458
Lee, Zhao, Moon, Yoon, Kim, An, Kwon, Hwang, Choi, Shim, Kim, Yang: Differential involvement of GABA system in mediating behavioral and neurochemical effect of acupuncture in ethanol-withdrawn rats. dans Neuroscience letters 2008
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we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (Montrer ROR2 Anticorps), which influenced Ras Homology Family Member A (Montrer CXCL14 Anticorps) (RhoA (Montrer RHOA Anticorps)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (Montrer ROCK1 Anticorps)) activity downstream of Dishevelled-2 (Dvl2).
Epsins are required for Dishevelled stability and Wnt (Montrer WNT2 Anticorps) signalling activation in colon cancer development.
Dpr1 (Montrer DACT1 Anticorps) promotes the ubiquitination of Dvl2 by pVHL (Montrer VHL Anticorps) and mediates the protein aggregate-elicited autophagy initiation
Dvl2 binds to Rab35 (Montrer RAB35 Anticorps) and activation is required for MCF-7 cell migration
Dvl-2 and Dvl-3 (Montrer DVL3 Anticorps) have a widespread distribution in both the olfactory epithelium and olfactory bulb
Dullard (Montrer DULLARD Anticorps) may play a role in the fine-tuning of WNT (Montrer WNT2 Anticorps) signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage.
loss of Dvl2 function in Vangl2(Lp (Montrer VANGL2 Anticorps)/+) embryos did not exacerbate the Vangl2(Lp (Montrer VANGL2 Anticorps)/+) neuronal migration phenotype
Identification of a novel Wnt5a (Montrer WNT5A Anticorps)-CK1varepsilon-Dvl2-Plk1 (Montrer PLK1 Anticorps)-mediated primary cilia disassembly pathway.
These findings suggest that Wnt5a (Montrer WNT5A Anticorps)-Ror-Dishevelled signaling constitutes a core noncanonical Wnt (Montrer WNT2 Anticorps) pathway that is conserved through evolution and is crucial during embryonic development.
Dvl2 has an inhibitory role in myogenesis and Stau1 (Montrer STAU1 Anticorps) coordinates myogenesis through the regulation of Dvl2 mRNA.
we found that Wnt3a (Montrer WNT3A Anticorps) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3 (Montrer DVL3 Anticorps). Our findings suggest a model of positive regulation of PKCzeta (Montrer PRKCZ Anticorps)-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a (Montrer WNT3A Anticorps) treatment by stabilizing Dvl protein levels.
Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP (Montrer ZDHHC21 Anticorps) domain in Wnt (Montrer WNT2 Anticorps) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling.
Data show that RAP1B (Montrer RAP1B Anticorps) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (Montrer RAP1B Anticorps) interacted with DVL2 and activated Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1 (Montrer DVL1 Anticorps), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (Montrer SFRP2 Anticorps) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
In pancreatic cancer cells, AF6 (Montrer MLLT4 Anticorps) is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (Montrer FOXE1 Anticorps)-induced trans-activation of Snail (Montrer SNAI1 Anticorps), which promotes proliferation and metastasis.
CapZIP (Montrer RCSD1 Anticorps), which has been shown to regulate ciliogenesis, is an ERK7 (Montrer MAPK15 Anticorps) substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 (Montrer MAPK15 Anticorps) phosphorylation of CapZIP (Montrer RCSD1 Anticorps) through binding to both ERK7 (Montrer MAPK15 Anticorps) and CapZIP (Montrer RCSD1 Anticorps).
Different Dvl proteins (Dvl1 (Montrer DVL1 Anticorps), Dvl2, Dvl3 (Montrer DVL3 Anticorps)) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (Montrer WNT2 Anticorps) signaling in Xenopus gastrulation.
these findings suggest that regulation of Dvl protein levels by NEDD4L (Montrer NEDD4L Anticorps) is essential for convergent extension during early Xenopus embryogenesis.
findings reveal that, in response to Wnt (Montrer WNT2 Anticorps) signalling, Dishevelled inhibits CSL (Montrer SMPX Anticorps) transcription factors to regulate Notch (Montrer NOTCH1 Anticorps) signalling and cell-fate decisions in vivo
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin (Montrer Actbeta Anticorps).
The archenteron elongation is independent of Xdsh signaling, especially during the second half of gastrulation.
Subcellular localization is insufficient to account for the pathway specificity of Dishevelled in the canonical Wnt (Montrer WNT2 Anticorps) versus PCP (Montrer PRCP Anticorps) signaling cascades.
both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells
Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 (Montrer EFNB1 Anticorps) and mediates ephrinB1 (Montrer EFNB1 Anticorps) signalling through downstream members of the PCP (Montrer PRCP Anticorps) pathway during eye field formation.
The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.
demonstrate that during early zebrafish development Nkd1 (Montrer NKD1 Anticorps) does not alter either endogenous or exogenous levels of Dvl2
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
DSH homolog 2
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2
, dishevelled 2
, dishevelled, dsh homolog 2 (Drosophila)
, dishevelled 2 (homologous to Drosophila dsh)
, dishevelled homolog
, dishevelled 2, dsh homolog