Aperçu des produits pour anti-GRHL2 (GRHL2) Anticorps

Zebrafish Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

1. The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.

2. This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.

Human Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

1. GRHL2 gene may have a role in orbital innervations and the defect in this gene (deletion) may be related to the Congenital fibrosis of the extraocular muscles type 1 phenotype.

2. In this study, we demonstrated for the first time that GRHL2 has a functional role in the regulation of epithelial plasticity of PDAC cells.

3. data analysis and modeling results highlight the relationships among multiple crucial Epithelial-to-Mesenchymal Transition /Mesenchymal-to-Epithelial Transition drivers including ZEB1 (Montrer ZEB1 Anticorps), GRHL2, CD24 (Montrer CD24 Anticorps), and ESRP1 (Montrer ESRP1 Anticorps), particularly in basal-like breast cancers, which are most similar to triple-negative breast cancer (TNBC) and are considered the most dangerous subtype

4. Data indicate a 'phenotypic stability factors' (PSFs) such as GRHL2 that couple to the core epithelial-to-mesenchymal transition (EMT (Montrer ITK Anticorps)) decision-making circuit (miR (Montrer MLXIP Anticorps)-200/ZEB (Montrer ZEB1 Anticorps)) and stabilize hybrid epithelial/mesenchymal (hybrid E/M) E/M phenotype.

5. All of these processes involve epithelial-mesencyhmal transition (EMT (Montrer ITK Anticorps)), MET or a sequence of both, suggesting that the GRHL (Montrer GHRL Anticorps) factors((GRHL1 (Montrer GRHL1 Anticorps), GRHL2 and GRHL3 (Montrer GRHL3 Anticorps)), could potentially affect tumor initiation and progression via EMT (Montrer ITK Anticorps)

6. Silencing of GRHL2 expression in non-tumorigenic kidney cell line results in increased cell proliferation, increased resistance to apoptosis, as well as changes in the levels of selected proteins involved in the pathogenesis of clear cell renal cell carcinoma (Montrer MOK Anticorps) (ccRCC). These changes support the potential role for GRHL2 as a suppressor of ccRCC.

7. Results demonstrate a mechanistic role for GRHL2 in promoting anoikis through metabolic alterations.

8. GRHL2 maintained AR expression in multiple prostate cancer model systems, was required for cell proliferation, enhanced AR's transcriptional activity, and colocated with AR at specific sites on chromatin to regulate genes relevant to disease progression.

9. Studies indicate that Grainyhead-like transcription factor 2 (Montrer HNF1B Anticorps) (GRHL2) controls the expression of E-cadherin (CDH1 (Montrer CDH1 Anticorps)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4 (Montrer CLDN4 Anticorps)) in tight junctions.

10. results indicated GRHL2 might be a noise-induced hearing loss (NIHL) susceptibility gene, but the effect of POU4F3 (Montrer POU4F3 Anticorps) on NIHL could only be detected when taking noise exposure into account and their effects were enhanced by higher levels of noise exposure

Mouse (Murine) Grainyhead-Like 2 (Drosophila) (GRHL2) interaction partners

1. Results indicate GRHL2 as a novel progenitor cell maker in the developing pituitary that may contribute to progenitor cell function and maintenance.

2. GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (Montrer ITK Anticorps)) transition through novel downstream EMT (Montrer ITK Anticorps) suppressors.

3. a Grhl2/Ovol2 (Montrer OVOL2 Anticorps) network controls Cldn4 (Montrer CLDN4 Anticorps) and Rab25 (Montrer RAB25 Anticorps) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

4. Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.

5. expression of GRHL2 is directly suppressed by the ZEB1 (Montrer ZEB1 Anticorps), which in turn is a direct target for repression by GRHL2, suggesting that the EMT (Montrer ITK Anticorps) transcription factors GRHL2 and ZEB1 (Montrer ZEB1 Anticorps) form a double negative regulatory feedback loop

6. Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (Montrer ITK Anticorps) and tumor progression

7. the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (Montrer CLDN3 Anticorps) and Cldn4 (Montrer CLDN4 Anticorps), as well as of Rab25 (Montrer RAB25 Anticorps), which increases the Cldn4 (Montrer CLDN4 Anticorps) protein and its localization at TJs

8. Grhl2 and Nkx2-1 (Montrer NKX2-1 Anticorps) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.

9. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

10. tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (Montrer TFAP2A Anticorps) null mutants and AP-2alpha (Montrer TFAP2A Anticorps) has been shown to bind to the promoter of E-cadherin (Montrer CDH1 Anticorps)