Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Human GRHL2 Anticorps:
anti-Rat (Rattus) GRHL2 Anticorps:
anti-Mouse (Murine) GRHL2 Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Human Polyclonal GRHL2 Primary Antibody pour ICC, IF - ABIN4316153
Varma, Cao, Tagne, Lakshminarayanan, Li, Friedman, Morell, Warburton, Kotton, Ramirez: The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. dans The Journal of biological chemistry 2012
Show all 8 Pubmed References
Human Polyclonal GRHL2 Primary Antibody pour ELISA, WB - ABIN566411
Kang, Chen, Kim, Kang, Park: Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. dans Oncogene 2009
Show all 4 Pubmed References
Human Polyclonal GRHL2 Primary Antibody pour IF, WB - ABIN529152
Dompe, Rivers, Li, Cordes, Schwickart, Punnoose, Amler, Seshagiri, Tang, Modrusan, Davis: A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. dans Proceedings of the National Academy of Sciences of the United States of America 2011
Show all 2 Pubmed References
The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.
This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.
GRHL2 gene may have a role in orbital innervations and the defect in this gene (deletion) may be related to the Congenital fibrosis of the extraocular muscles type 1 phenotype.
In this study, we demonstrated for the first time that GRHL2 has a functional role in the regulation of epithelial plasticity of PDAC cells.
data analysis and modeling results highlight the relationships among multiple crucial Epithelial-to-Mesenchymal Transition /Mesenchymal-to-Epithelial Transition drivers including ZEB1 (Montrer ZEB1 Anticorps), GRHL2, CD24 (Montrer CD24 Anticorps), and ESRP1 (Montrer ESRP1 Anticorps), particularly in basal-like breast cancers, which are most similar to triple-negative breast cancer (TNBC) and are considered the most dangerous subtype
Data indicate a 'phenotypic stability factors' (PSFs) such as GRHL2 that couple to the core epithelial-to-mesenchymal transition (EMT (Montrer ITK Anticorps)) decision-making circuit (miR (Montrer MLXIP Anticorps)-200/ZEB (Montrer ZEB1 Anticorps)) and stabilize hybrid epithelial/mesenchymal (hybrid E/M) E/M phenotype.
All of these processes involve epithelial-mesencyhmal transition (EMT (Montrer ITK Anticorps)), MET or a sequence of both, suggesting that the GRHL (Montrer GHRL Anticorps) factors((GRHL1 (Montrer GRHL1 Anticorps), GRHL2 and GRHL3 (Montrer GRHL3 Anticorps)), could potentially affect tumor initiation and progression via EMT (Montrer ITK Anticorps)
Silencing of GRHL2 expression in non-tumorigenic kidney cell line results in increased cell proliferation, increased resistance to apoptosis, as well as changes in the levels of selected proteins involved in the pathogenesis of clear cell renal cell carcinoma (Montrer MOK Anticorps) (ccRCC). These changes support the potential role for GRHL2 as a suppressor of ccRCC.
Results demonstrate a mechanistic role for GRHL2 in promoting anoikis through metabolic alterations.
GRHL2 maintained AR expression in multiple prostate cancer model systems, was required for cell proliferation, enhanced AR's transcriptional activity, and colocated with AR at specific sites on chromatin to regulate genes relevant to disease progression.
Studies indicate that Grainyhead-like transcription factor 2 (Montrer HNF1B Anticorps) (GRHL2) controls the expression of E-cadherin (CDH1 (Montrer CDH1 Anticorps)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4 (Montrer CLDN4 Anticorps)) in tight junctions.
results indicated GRHL2 might be a noise-induced hearing loss (NIHL) susceptibility gene, but the effect of POU4F3 (Montrer POU4F3 Anticorps) on NIHL could only be detected when taking noise exposure into account and their effects were enhanced by higher levels of noise exposure
Results indicate GRHL2 as a novel progenitor cell maker in the developing pituitary that may contribute to progenitor cell function and maintenance.
GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (Montrer ITK Anticorps)) transition through novel downstream EMT (Montrer ITK Anticorps) suppressors.
a Grhl2/Ovol2 (Montrer OVOL2 Anticorps) network controls Cldn4 (Montrer CLDN4 Anticorps) and Rab25 (Montrer RAB25 Anticorps) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.
expression of GRHL2 is directly suppressed by the ZEB1 (Montrer ZEB1 Anticorps), which in turn is a direct target for repression by GRHL2, suggesting that the EMT (Montrer ITK Anticorps) transcription factors GRHL2 and ZEB1 (Montrer ZEB1 Anticorps) form a double negative regulatory feedback loop
Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (Montrer ITK Anticorps) and tumor progression
the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (Montrer CLDN3 Anticorps) and Cldn4 (Montrer CLDN4 Anticorps), as well as of Rab25 (Montrer RAB25 Anticorps), which increases the Cldn4 (Montrer CLDN4 Anticorps) protein and its localization at TJs
Grhl2 and Nkx2-1 (Montrer NKX2-1 Anticorps) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.
Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse
tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (Montrer TFAP2A Anticorps) null mutants and AP-2alpha (Montrer TFAP2A Anticorps) has been shown to bind to the promoter of E-cadherin (Montrer CDH1 Anticorps)
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
, grainyhead-like 2b protein
, grainyhead-like protein 2 homolog
, grainyhead-like 2 (Drosophila)
, brother of mammalian grainyhead
, transcription factor CP2-like 3
, grainyhead like 2
, grainyhead-like 2a
, grainyhead-like transcription factor 2a