GBP1 anticorps (AA 400-592)

N° du produit ABIN7864722

Cet anticorps Souris Monoclonal détecte spécifiquement GBP1 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour GBP1 anticorps (AA 400-592) (ABIN7864722)

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GBP1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: GBP1-7617

Détail du produit anti-GBP1 anticorps

Épitope: AA 400-592

Fonction: GBP1 Antibody

Specificité: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa400-592) of human GBP1 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur GBP1

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Autre désignation: GBP1

Sujet:

GTP binding protein 1, Guanine nucleotide binding protein 1, Guanylate binding protein 1 interferon inducible 67 kDa, HuGBP1, Interferon induced guanylate binding protein 1, OTTHUMP00000012352

Human colon or cerebral cortex tissue.

Poids moléculaire: 67kDa

ID gène: 2633, 62661

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin