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ACE Inhibitor Pathway

ACE Inhibitor Pathway

L'enzyme de conversion de l'angiotensine, ou ECA, est un composant central du système rénine-angiotensine (SRA), qui contrôle la pression artérielle en régulant le volume des liquides dans l'organisme. Les inhibiteurs de l'ECA sont utilisés en médecine pour le traitement des maladies cardiovasculaires...

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Apoptose

Apoptose

L'apoptose est un processus très réglé permettant à un organisme d'éliminer de façon organisée les cellules qui ne sont plus utiles. Il est initié soit par une catégorie spécifique de récepteurs de mort soit par des facteurs intrinsèques tels que des dommages à l'ADN. L'apoptose est principalement due à des protéases de caspase et régulée également par les protéines Bcl-2 et inhibitrices. La dérégulation de cette mort programmée de cellules est souvent associée au cancer.

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Autophagy

Autophagy

Autophagy is the regulated, self-degradative process of the cell that disassembles unnecessary or dysfunctional components. The lysosomal pathway is evolutionarily conserved and initiates engulfment, degradation and recycling of cellular contents including long-lived proteins and organelles thus promoting cell survival.

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BCR Signaling

BCR Signaling

La signalisation du récepteur des cellules B (BCR) est essentielle pour la survie et le développement des cellules B et la production d'anticorps dans des conditions physiologiques et pathologiques. La signalisation d'amorçage pilotée par l'antigène est importante pour l'initiation de l'activation des cellules B et leur différenciation en cellules sécrétrices d'anticorps. D'autre part, la signalisation tonique du BCR est nécessaire à la survie et au développement des cellules B alors que la signalisation chronique est essentielle à la prolifération des cellules de lymphome à cellules B.

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Cancer Immune Checkpoints

Cancer Immune Checkpoints

Les points de contrôle immunitaire ("Immune Checkpoints") sont des récepteurs situés sur la membrane des lymphocytes T qui peuvent alterner leur réponse immunitaire. Ils régulent ainsi la réponse immunitaire soit par stimulation, soit par inhibition. Cette voie est cruciale pour promouvoir l'autotolérance et prévenir l'auto-immunité et les maladies associées.

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Cycle Cellulaire

Cycle Cellulaire

La division cellulaire se déroule en quatre étapes - phase G1, S, G2 et M - en fonction d'un certain nombre de signaux internes ou externes. La progression à travers les différentes phases est pilotée par les kinases dépendantes des cyclines (CDK) et leurs activateurs, les cyclines. En outre, leur activité est modulée par les inhibiteurs des CDK. Un contrôle étroit du cycle cellulaire est essentiel pour maintenir une homéostasie cellulaire adéquate.

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Dynamique des Microtubules

Dynamique des Microtubules

Les microtubules sont des routes intracellulaires structurelles et fonctionnelles hautement dynamiques. Le terme cytosquelette évoque l'image d'une structure rigide, immuable et permanente. En réalité, le cytosquelette est un réseau interconnecté fortement dynamique constitué de trois différents composants principaux : les microtubules...

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Human Leukocyte Antigen (HLA) in Adaptive Immune Response

Human Leukocyte Antigen (HLA) in Adaptive Immune Response

The Major Histocompatibility Complex (MHC) comprises a number of genes that occur in many species. The encoded proteins help the immune system to tell the body's own proteins apart from those of pathogens such as viruses, bacteria, and protozoans. In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6.

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Inflammasome

Inflammasome

Les inflammmasomes sont des complexes multiprotéiques situés dans le cytosol. Ils se composent généralement d'une protéine de détection, d'une protéine adaptatrice contenant un domaine de recrutement des caspases et d'une caspase pro-inflammatoire. Dans le cas de l'inflammasome NLRP3, actuellement l'inflammasome le mieux caractérisé, les protéines respectives sont NLRP3, ASC/PYCARD et CASP1.

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Lipid Metabolism

Lipid Metabolism

Lipids are omnipresent in a multitude of vital cell processes. Cells use lipids to store energy, build membranes, signal within and between cells, sense the environment, covalently modify proteins, form specialized permeability barriers (e.g., in skin), and protect cells from highly reactive chemicals.

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Phosphorylation & l'infection par le SRAS-CoV-2

Phosphorylation & l'infection par le SRAS-CoV-2

Plusieurs vaccins contre le SRAS-CoV-2 ont déjà été approuvés. Le paysage de la phosphorylation de l'infection par le SRAS-CoV-2 présenté ici est une étape vers une meilleure compréhension de la relation virus-hôte et le développement de vaccins.

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Réparation de l'ADN

Réparation de l'ADN

Tout organisme est doté de différents mécanismes de réparation de l’ADN assurant l’intégrité de l’information génétique contenue dans le noyau de chaque cellule. L’importance cruciale que revêt le maintien de l’intégrité de l’ADN se reflète dans la multitude de voies de réparation de l’ADN et dans la diversité des protéines impliquées dans ces processus.

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SARS-CoV-2 Protein Interactome

SARS-CoV-2 Protein Interactome

Le SARS-CoV-2 est un bêta-coronavirus à ARN simple brin, enveloppé, à sens positif, appartenant à l'ordre des nidovirales. Au cours des trois premiers mois depuis son identification initiale en décembre 2019, le SRAS-CoV-2 a causé plus de 800 000 cas confirmés et plus de 40 000 décès dans le monde entier du syndrome respiratoire aigu sévère associé COVID-19 (coronavirus disease 2019).

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Signalisation Hedgehog

Signalisation Hedgehog

La cascade de signaux Hedgehog (Hh) est l’un des éléments les plus importants de nombreux processus de développement. Ce sont les produits génétiques des gènes ciblés qui déterminent le caractère souche des cellules, leur renouvellement, leur survie et leur migration. Un dérèglement des protéines Hh et des effecteurs en aval joue un rôle important dans la progression des cancers.

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Signalisation MAPK

Signalisation MAPK

La phosphorylation est le processus réversible d'addition d'un groupe phosphate à un résidu spécifique d'acide aminé sur une molécule. Sur le plan fonctionnel, la phosphorylation agit comme un simple commutateur moléculaire qui peut activer, désactiver ou moduler la fonction d'une protéine.

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Signalisation NF-kappaB

Signalisation NF-kappaB

Les NF-kappaB (facteurs nucléaires améliorateurs de chaîne légère kappa de cellules B activées) sont un groupe de facteurs de transcription homo- ou hétérodimétriques qui jouent un rôle capital dans un réseau de nombreuses voies de transduction de signaux...

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Signalisation Notch

Signalisation Notch

La voie de signalisation Notch, bien conservée, est unique en son genre car le récepteur Notch et la plupart de ses ligands respectifs (canoniquement ceux de la famille DSL ou Delta/Serrate/LAG-2) sont des protéines transmembranaires fixées à la surface de la cellule. ...

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Signalisation p53

Signalisation p53

p53 est l'un des plus importants suppresseurs de tumeurs, appelé souvent « le Gardien de l'intégrité du génome ». On retrouve des mutations du p53 ou de certaines parties de son circuit de régulation dans presque tous les cancers, ce qui montre son importance. Il conserve la stabilité du génome en prévenant les mutations causées...

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Signalisation PI3K-Akt

Signalisation PI3K-Akt

La transduction de signal PI3K/Akt a un rôle charnière dans l’homéostasie cellulaire, le développement neurologique, le métabolisme et d’autres processus. Elle régule différents aspects du développement cellulaire comme l’apoptose, la progression du cycle cellulaire et la différenciation cellulaire. Le régulateur principal du signal PI3K/Akt est Akt/PKB, une famille de trois protéines kinases...

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Signalisation RTK

Signalisation RTK

Les récepteurs tyrosine kinase (RTK) sont des kinases liées à la membrane qui sont activées lorsque les ligands spécifiques aux récepteurs se lient. Ils constituent la plus grande classe de récepteurs de membrane qui provoquent des cascades de signalisation via leur activité enzymatique inhérente.

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Signalisation TLR

Signalisation TLR

Les récepteurs de type Toll jouent un rôle essentiel dans la réponse immunitaire innée contre divers agents pathogènes tels que les virus, les bactéries et les champignons. Les TLR déclenchent l'une des deux voies inflammatoires conservées : la voie TRIF ou la voie MyD88. En outre, la signalisation TLR induit également la maturation des cellules dendritiques et la réponse immunitaire adaptative.

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Signalisation WNT

Signalisation WNT

Les Wnt sont une classe de glycoprotéines modifiées par des lipides, conservées au cours de l'évolution, qui jouent un rôle central dans le développement et l'homéostasie par le biais d'un certain nombre de voies de transduction de signaux paracrines et autocrines différentes.

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Signalistation JAK/STAT

Signalistation JAK/STAT

La signalisation JAK-STAT est hautement conservée chez les vertébrés et même d’autres métazoaires. L’association de kinases activées par les récepteurs et de facteurs de...

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Système du Complément

Système du Complément

Le système du complément fait partie du système immunitaire inné, et il joue un rôle essentiel dans la défense...

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TCR Signaling

TCR Signaling

The T-Cell Receptor (TCR) is a protein complex on the surface of T-cell responsible for the recognition of antigens on the surface of antigen presenting cells (APC). Cell surface glycoproteins CD4 and CD8 serve as coreceptors with the TCR primarily for the interaction with the major histocompatibility complex class II (MHC II) loaded with peptides derived from cytosolic proteins and MHC I with extracellular protein peptides respectively. Activation of the TCR induces a number of signaling cascades, ultimately leading to the transcription of several gene products essential for T cells differentiation, proliferation and secretion of a number of cytokines.

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Ubiquitin Proteasome Pathway

Ubiquitin Proteasome Pathway

Unlike most regulatory mechanisms, protein degradation is inherently irreversible. Destruction of a protein can lead to a complete, rapid, and sustained termination of the process involving the protein as well as a change in cell composition. The rapid degradation of specific proteins permits adaptation to new physiologic conditions.

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Unfolded Protein Response

Unfolded Protein Response

La réponse aux protéines non repliées (UPR) est une réponse de stress cellulaire activée dans les cellules eucaryotes en réponse au stress du réticulum endoplasmique (RE), une accumulation de protéines non repliées dans la lumière du RE.

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VEGF Signaling

VEGF Signaling

Vascular endothelial growth factors (VEGFs) constitute a sub-family of growth factors that stimulate the growth of new blood vessels. VEGFs are important signaling proteins and initiate angiogenesis via several signalling cascades.

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Activated T Cell Proliferation

Browse our antibodies, ELISA kits and proteins related to activated T cell proliferation.

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Activation of Innate immune Response

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AMPK Signaling

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Asymmetric Protein Localization

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Brown Fat Cell Differentiation

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C21-Steroid Hormone Metabolic Process

Browse our antibodies, ELISA kits and proteins related to C21-steroid hormone metabolic process.

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cAMP Metabolic Process

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Carbohydrate Homeostasis

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Caspase Cascade in Apoptosis

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Cell RedoxHomeostasis

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Cell-Cell Junction Organization

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Cellular Glucan Metabolic Process

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Cellular Response to Molecule of Bacterial Origin

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Chromatin Binding

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CXCR4-mediated Signaling Events

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Dicarboxylic Acid Transport

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DNA Replication

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Dopaminergic Neurogenesis

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EGFR Downregulation

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EGFR Signaling Pathway

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Embryonic Body Morphogenesis

Browse our antibodies, ELISA kits and proteins related to embryonic body morphogenesis.

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ER-Nucleus Signaling

Browse our antibodies, ELISA kits and proteins related to the ER-nucleus signaling pathway.

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Fc-epsilon Receptor Signaling Pathway

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Feeding Behaviour

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G-protein mediated Events

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Glycosaminoglycan Metabolic Process

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Growth Factor Binding

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Hepatitis C

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Hormone Activity

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Hormone Transport

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Inositol Metabolic Process

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Integrin Complex

Browse our antibodies, ELISA kits and proteins related to the integrin complex.

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Interaction of EGFR with phospholipase C-gamma

Browse our antibodies, ELISA kits and proteins related EGFR and its interaction with phospholipase C-gamma.

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Interferon-gamma Pathway

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Intracellular Steroid Hormone Receptor Signaling Pathway

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M Phase

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Maintenance of Protein Location

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Metabolism of Steroid Hormones and Vitamin D

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Methionine Biosynthetic Process

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Mitotic G1-G1/S Phases

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Monocarboxylic Acid Catabolic Process

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Myometrial Relaxation and Contraction

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Negative Regulation of Hormone Secretion

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Negative Regulation of intrinsic apoptotic Signaling

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Negative Regulation of Transporter Activity

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Neurotrophin Signaling Pathway

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Nuclear Hormone Receptor Binding

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Nuclear Receptor Transcription Pathway

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Nucleotide Phosphorylation

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Peptide Hormone Metabolism

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Photoperiodism

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Phototransduction

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Platelet-derived growth Factor Receptor Signaling

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Positive Regulation of Endopeptidase Activity

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Positive Regulation of fat Cell Differentiation

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Positive Regulation of Immune Effector Process

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Positive Regulation of Peptide Hormone Secretion

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Positive Regulation of Response to DNA Damage Stimulus

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Production of Molecular Mediator of Immune Response

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Protein targeting to Nucleus

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Proton Transport

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Regulation of Actin Filament Polymerization

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Regulation of Carbohydrate Metabolic Process

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Regulation of Cell Size

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Regulation of G-Protein Coupled Receptor Protein Signaling

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Regulation of Hormone Biosynthetic Process

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Regulation of Hormone Metabolic Process

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Regulation of Intracellular Steroid Hormone Receptor Signaling

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Regulation of Leukocyte Mediated Immunity

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Regulation of Lipid Metabolism by PPARalpha

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Regulation of long-term Neuronal Synaptic Plasticity

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Regulation of Muscle Cell Differentiation

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Regulation of Systemic Arterial Blood Pressure by Hormones

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Regulatory RNA Pathways

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Response to Growth Hormone Stimulus

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Response to Water Deprivation

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Retinoic Acid Receptor Signaling Pathway

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Ribonucleoprotein Complex Subunit Organization

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Ribonucleoside Biosynthetic Process

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Ribosome Assembly

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Sensory Perception of Sound

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Signaling Events mediated by VEGFR1 and VEGFR2

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Signaling of Hepatocyte Growth Factor Receptor

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Skeletal Muscle Fiber Development

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Smooth Muscle Cell Migration

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Stem Cell Maintenance

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Steroid Hormone Biosynthesis

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Steroid Hormone Mediated Signaling Pathway

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Synaptic Membrane

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Synaptic Vesicle Exocytosis

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Synthesis of DNA

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Telomere Maintenance

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Thromboxane A2 Receptor Signaling

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Thyroid Hormone Synthesis

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Toll-Like Receptors Cascades

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Transition Metal Ion Homeostasis

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Tube Formation

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VEGFR1 Specific Signals

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