Tel:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@anticorps-enligne.fr

Ion Channels

Ion channels are pore-forming proteins that allow the flow of ions across membranes, either plasma membranes or the membranes of intracellular organelles. Many ion channels (such as most Na, K Ca and some Cl channels) are gated by voltage but others (such as certain K and Cl channels, TRP channels, ryanodine receptors and IP3 receptors) are relatively voltage-insensitive and are gated by second messengers and other intracellular and/or extracellular mediators.(1)

Most ion channels are highly selective for the class of ions crossing the channel. They can therefore be easily classified into sodium channels, calcium channels, potassium channels, proton channels or non-selective cation channels. Research on ion channels requires a large number of methods and materials. We offer monoclonal and polyclonal antibodies, ELISA kits and high-quality made-to-order proteins for this complex topic.

Aquaporins

Aquaporins (often called aquaporin water channels) are a family of small, integral membrane proteins that are expressed broadly throughout the animal and plant kingdoms. They have a similar basic structure, with aquaporin monomers consisting of six transmembrane helical segments and two short helical segments that surround cytoplasmic and extracellular vestibules connected by a narrow aqueous pore.(2)

To search our Aquaporin antibodies, kits, proteins click on the links below.

Calcium Channels

A calcium channel is a transmembrane ion channel that is permeable to calcium ions. The permeability is controlled either by voltage-gated calcium channels or ligand-gated calcium channels. We offer some hand-picked monoclonal and polyclonal antibodies for research on calcium channels.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationICC, IF, IP, IHC, WB
N° du produitABIN1721482
Quantité100 μg
ReactivityHuman, Mouse, Rabbit, Rat
ClonalitéMonoclonal
ApplicationICC, FACS, IF, IP, IHC, WB
N° du produitABIN1721483
Quantité100 μg
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationIHC, WB
N° du produitABIN1098196
Quantité100 μg
ReactivityRat
ClonalitéMonoclonal
ApplicationFM, IHC, IP, WB
N° du produitABIN6658066
Quantité100 μg
ReactivityMammalian
ClonalitéMonoclonal
ApplicationISt, IHC, WB
N° du produitABIN1304586
Quantité5 mL
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationICC, IF, IHC, WB
N° du produitABIN1721488
Quantité100 μg
ReactivityHuman, Mouse
ClonalitéPolyclonal
ApplicationICC, IF, IHC (p), WB
N° du produitABIN2854649
Quantité100 μL
ReactivityMammalian
ClonalitéMonoclonal
ApplicationISt, IHC, WB
N° du produitABIN1304590
Quantité5 mL

See all Calcium Channel Antibodies

Potassium Channels

Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting other ions.(3)

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
ReactivityMouse
ClonalitéMonoclonal
ApplicationIHC, IP, WB
N° du produitABIN6657685
Quantité100 μg
ReactivityMouse
ClonalitéMonoclonal
ApplicationFM, IHC, IP, WB
N° du produitABIN6657686
Quantité100 μg
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationICC, FACS, IF, IP, IHC, WB
N° du produitABIN1721589
Quantité100 μg
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationICC, FACS, IF, IP, IHC, WB
N° du produitABIN1721590
Quantité100 μg
ReactivityCow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep
ClonalitéPolyclonal
ApplicationWB
N° du produitABIN2776142
Quantité100 μL
ReactivityHuman
ClonalitéMonoclonal
ApplicationFACS, ELISA, WB
N° du produitABIN969227
Quantité100 μL
ReactivityHamster, Human, Mouse, Rat
ClonalitéMonoclonal
ApplicationAA, ICC, IF, IHC, IP, WB
N° du produitABIN2482775
Quantité100 μg
ReactivityHuman, Mouse, Pig, Rat
ClonalitéPolyclonal
ApplicationELISA
N° du produitABIN570733
Quantité100 μg
ReactivityHuman, Mouse
ClonalitéPolyclonal
ApplicationELISA, WB
N° du produitABIN3185286
Quantité100 μL

Sodium Channels

There are two major classes of sodium channels in mammals: The voltage-gated sodium channel (VGSC) family and the epithelial sodium channel (ESC). Voltage-gated sodium channels exist throughout the body in various cell types, while epithelial sodium channels are located primarily in the skin and kidney.(4)

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
ReactivityCow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
ClonalitéPolyclonal
ApplicationWB
N° du produitABIN2776229
Quantité100 μL
ReactivityHamster, Human, Mouse, Rat, Xenopus laevis
ClonalitéPolyclonal
ApplicationICC, IF, IHC, WB
N° du produitABIN863204
Quantité100 μg
ReactivityHuman, Mouse, Rat
ClonalitéPolyclonal
ApplicationIF (p), IHC (p), WB
N° du produitABIN713471
Quantité100 μL
ReactivityHamster, Human, Mouse, Rat, Xenopus laevis
ClonalitéPolyclonal
ApplicationICC, IF, IHC, WB
N° du produitABIN2486428
Quantité100 μg
ReactivityHuman
ClonalitéPolyclonal
ApplicationELISA, WB
N° du produitABIN565642
Quantité50 μL
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationICC, IF, WB
N° du produitABIN2483030
Quantité100 μg

TRP

Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.(5)

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
ReactivityHuman, Mouse, Rat
ClonalitéPolyclonal
ApplicationIHC, WB
N° du produitABIN351117
Quantité100 μL
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationAA, IHC, IP, WB
N° du produitABIN2485379
Quantité100 μg
ReactivityHuman, Chimpanzee
ClonalitéMonoclonal
ApplicationIHC, ELISA, WB
N° du produitABIN964697
Quantité100 μg
ReactivityDog, Human, Monkey
ClonalitéMonoclonal
ApplicationIHC, WB
N° du produitABIN2725815
Quantité0.1 mL
ReactivityHuman
ClonalitéPolyclonal
ApplicationEIA, IHC (p), WB
N° du produitABIN4620541
Quantité0.1 mg

See all TRP-related Antibodies

Cyclic Nucleotide-gated Ion Channels

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels.(6) Below you will find a selection of polyclonal antibodies against CNG ion channels.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
ReactivityHuman
ClonalitéPolyclonal
ApplicationICC, IF, IHC (p), WB
N° du produitABIN2856869
Quantité100 μL
ReactivityHuman
ClonalitéPolyclonal
ApplicationWB
N° du produitABIN1679299
Quantité100 μg
ReactivityMouse
ClonalitéPolyclonal
ApplicationIHC (p), WB
N° du produitABIN5532896
Quantité400 μL
ReactivityHuman
ClonalitéPolyclonal
ApplicationWB
N° du produitABIN5619308
Quantité100 μL

See all CNG ion channel Antibodies

Hyperpolarization-activated Cyclic Nucleotide-gated Channels (HCN)

A hyperpolarization-activated cyclic nucleotide-gated channel (HCN) is a subtype of CNG channel that is gated by hyperpolarization of the cell membrane. There are four HCN channels HCN1, HCN2, HCN3, and HCN4.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationAA, IHC, IP, WB
N° du produitABIN2483966
Quantité100 μg
ReactivityRat
ClonalitéMonoclonal
ApplicationFM, IHC, IP, WB
N° du produitABIN6658118
Quantité100 μg
ReactivityHuman, Mouse, Rat
ClonalitéMonoclonal
ApplicationAA, ICC, IF, IHC, WB
N° du produitABIN2483847
Quantité100 μg
ReactivityHuman, Mouse, Rat
ClonalitéPolyclonal
ApplicationIF (p), IHC (p), WB
N° du produitABIN733043
Quantité100 μL

See all HCN ion channel Antibodies

We offer you Made-to-order Channel Proteins

We offer high-purity made-to-order ion channel proteins with native state folding guarantee. Below you will find a selection of potassium channel proteins. Please contact us via email, chat, or phone for more information about our made-to-order proteins.

Produit
Protein Type
Conjugate
N° du produit
Quantité
Protein TypeRecombinant
ConjugateHis tag
N° du produitABIN3077909
Quantité1 mg
Protein TypeRecombinant
ConjugateHis tag
N° du produitABIN3081371
Quantité1 mg
Protein TypeRecombinant
ConjugateHis tag
N° du produitABIN3093393
Quantité1 mg
Protein TypeRecombinant
Conjugaterho-1D4 tag
N° du produitABIN3093343
Quantité0.5 mg
Protein TypeRecombinant
ConjugateHis tag
N° du produitABIN3130433
Quantité1 mg

References:

(1) Ion Channels. Br J Pharmacol. 2011 Nov;164(Suppl 1):S137–S174. doi: 10.1111/j.1476-5381.2011.01649_5.x. PMCID: PMC3315630.

(2) Verkman AS. Aquaporins. Curr Biol. 2013 Jan 21;23(2):R52-5. doi: 10.1016/j.cub.2012.11.025. PMID: 23347934; PMCID: PMC3590904.

(3) Kuang Q, Purhonen P, Hebert H. Structure of potassium channels. Cell Mol Life Sci. 2015 Oct;72(19):3677-93. doi: 10.1007/s00018-015-1948-5. Epub 2015 Jun 13. PMID: 26070303; PMCID: PMC4565861.

(4) Hernandez CM, Richards JR. Physiology, Sodium Channels. [Updated 2019 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545257/

(5) Dhakal S, Lee Y. Transient Receptor Potential Channels and Metabolism. Mol Cells. 2019 Aug 31;42(8):569-578. doi: 10.14348/molcells.2019.0007. PMID: 31446746; PMCID: PMC6715338.

(6) Kaupp UB, Seifert R. Cyclic nucleotide-gated ion channels. Physiol Rev. 2002 Jul;82(3):769-824.

Vous êtes ici:
help Support technique