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Ion Channels

Ion channels are pore-forming proteins that allow the flow of ions across membranes, either plasma membranes or the membranes of intracellular organelles. Many ion channels (such as most Na, K Ca and some Cl channels) are gated by voltage but others (such as certain K and Cl channels, TRP channels, ryanodine receptors and IP3 receptors) are relatively voltage-insensitive and are gated by second messengers and other intracellular and/or extracellular mediators.

Most ion channels are highly selective for the class of ions crossing the channel. They can therefore be easily classified into sodium channels, calcium channels, potassium channels, proton channels or non-selective cation channels. Research on ion channels requires a large number of methods and materials. We offer monoclonal and polyclonal antibodies, ELISA kits and high-quality made-to-order proteins for this complex topic.

Aquaporins

Aquaporins (often called aquaporin water channels) are a family of small, integral membrane proteins that are expressed broadly throughout the animal and plant kingdoms. They have a similar basic structure, with aquaporin monomers consisting of six transmembrane helical segments and two short helical segments that surround cytoplasmic and extracellular vestibules connected by a narrow aqueous pore.

To search our Aquaporin antibodies, kits, proteins click on the links below.

Calcium Channels

A calcium channel is a transmembrane ion channel that is permeable to calcium ions. The permeability is controlled either by voltage-gated calcium channels or ligand-gated calcium channels. We offer some hand-picked monoclonal and polyclonal antibodies for research on calcium channels.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Clonalité Polyclonal
Application ICC, IF, IHC (p), WB
N° du produit ABIN2854649
Quantité 100 μL
Reactivity Mammalian
Clonalité Monoclonal
Application ISt, IHC, WB
N° du produit ABIN1304590
Quantité 5 mL
Reactivity Human, Mouse, Rat
Clonalité Monoclonal
Application ICC, IF, IP, IHC, WB
N° du produit ABIN1721482
Quantité 100 μg
Reactivity Human, Mouse, Rabbit, Rat
Clonalité Monoclonal
Application ICC, FACS, IF, IP, IHC, WB
N° du produit ABIN1721483
Quantité 100 μg
Reactivity Human, Mouse, Rat
Clonalité Monoclonal
Application IHC, WB
N° du produit ABIN1098196
Quantité 100 μg
Reactivity Mammalian
Clonalité Monoclonal
Application ISt, IHC, WB
N° du produit ABIN1304586
Quantité 5 mL

See all Calcium Channel Antibodies

Potassium Channels

Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting other ions.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Clonalité Monoclonal
Application ICC, FACS, IF, IP, IHC, WB
N° du produit ABIN1721589
Quantité 100 μg
Reactivity Human, Mouse, Rat
Clonalité Monoclonal
Application ICC, FACS, IF, IP, IHC, WB
N° du produit ABIN1721590
Quantité 100 μg
Reactivity Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep
Clonalité Polyclonal
Application WB
N° du produit ABIN2776142
Quantité 100 μL
Reactivity Mouse
Clonalité Monoclonal
Application FM, IHC, IP, WB
N° du produit ABIN6657686
Quantité 100 μg
Reactivity Mouse
Clonalité Monoclonal
Application IHC, IP, WB
N° du produit ABIN6657685
Quantité 100 μg
Reactivity Human
Clonalité Monoclonal
Application FACS, ELISA, WB
N° du produit ABIN969227
Quantité 100 μL
Reactivity Human, Mouse, Pig, Rat
Clonalité Polyclonal
Application ELISA
N° du produit ABIN570733
Quantité 100 μg
Reactivity Human, Mouse
Clonalité Polyclonal
Application ELISA, WB
N° du produit ABIN3185286
Quantité 100 μL

Sodium Channels

There are two major classes of sodium channels in mammals: The voltage-gated sodium channel (VGSC) family and the epithelial sodium channel (ESC). Voltage-gated sodium channels exist throughout the body in various cell types, while epithelial sodium channels are located primarily in the skin and kidney.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
Fiche technique
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Clonalité Polyclonal
Application WB
N° du produit ABIN2776229
Quantité 100 μL
Reactivity Human
Clonalité Polyclonal
Application ELISA, WB
N° du produit ABIN565642
Quantité 50 μL
Reactivity Hamster, Human, Mouse, Rat, Xenopus laevis
Clonalité Polyclonal
Application ICC, IF, IHC, WB
N° du produit ABIN863204
Quantité 100 μg
Reactivity Human, Mouse
Clonalité Polyclonal
Application ELISA, IF (cc), IF (p), IHC (fro), WB
N° du produit ABIN713471
Quantité 100 μL
Reactivity Hamster, Human, Mouse, Rat, Xenopus laevis
Clonalité Polyclonal
Application ICC, IF, IHC, WB
N° du produit ABIN2486428
Quantité 100 μg
Reactivity Human, Mouse, Rat
Clonalité Monoclonal
Application ICC, IF, WB
N° du produit ABIN2483030
Quantité 100 μg

TRP

Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Clonalité Polyclonal
Application IHC, WB
N° du produit ABIN351117
Quantité 100 μL
Reactivity Human, Mouse, Rat
Clonalité Monoclonal
Application AA, IHC, IP, WB
N° du produit ABIN2485379
Quantité 100 μg
Reactivity Human, Chimpanzee
Clonalité Monoclonal
Application IHC, ELISA, WB
N° du produit ABIN964697
Quantité 100 μg
Reactivity Dog, Human, Monkey
Clonalité Monoclonal
Application IHC, WB
N° du produit ABIN2725815
Quantité 0.1 mL

See all TRP-related Antibodies

Cyclic Nucleotide-gated Ion Channels

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels. Below you will find a selection of polyclonal antibodies against CNG ion channels.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
Fiche technique
Reactivity Human
Clonalité Polyclonal
Application ICC, IF, IHC (p), WB
N° du produit ABIN2856869
Quantité 100 μL
Reactivity Human
Clonalité Polyclonal
Application WB
N° du produit ABIN5619308
Quantité 100 μL

See all CNG ion channel Antibodies

Hyperpolarization-activated Cyclic Nucleotide-gated Channels (HCN)

A hyperpolarization-activated cyclic nucleotide-gated channel (HCN) is a subtype of CNG channel that is gated by hyperpolarization of the cell membrane. There are four HCN channels HCN1, HCN2, HCN3, and HCN4.

Produit
Reactivity
Clonalité
Application
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Clonalité Monoclonal
Application AA, IHC, IP, WB
N° du produit ABIN2483966
Quantité 100 μg
Reactivity Rat
Clonalité Monoclonal
Application FM, IHC, IP, WB
N° du produit ABIN6658118
Quantité 100 μg
Reactivity Dog, Human, Mouse, Rat
Clonalité Polyclonal
Application IF (cc), IF (p), IHC (fro), IHC (p), WB
N° du produit ABIN733043
Quantité 100 μL

See all HCN ion channel Antibodies

We offer you Made-to-order Channel Proteins

We offer high-purity made-to-order ion channel proteins with native state folding guarantee. Below you will find a selection of potassium channel proteins. Please contact us via email, chat, or phone for more information about our made-to-order proteins.

Produit
Protein Type
Conjugué
N° du produit
Quantité
Fiche technique
Protein Type Recombinant
Conjugué His tag
N° du produit ABIN3077909
Quantité 1 mg
Protein Type Recombinant
Conjugué His tag
N° du produit ABIN3081371
Quantité 1 mg
Protein Type Recombinant
Conjugué His tag
N° du produit ABIN3093393
Quantité 1 mg
Protein Type Recombinant
Conjugué rho-1D4 tag
N° du produit ABIN3093343
Quantité 0.5 mg
Protein Type Recombinant
Conjugué His tag
N° du produit ABIN3130433
Quantité 1 mg

References:

Verkman: "Aquaporins." dans: Current biology : CB, Vol. 23, Issue 2, pp. R52-5, (2013) (PubMed).

Kuang, Purhonen, Hebert: "Structure of potassium channels." dans: Cellular and molecular life sciences : CMLS, Vol. 72, Issue 19, pp. 3677-93, (2015) (PubMed).

Dhakal, Lee: "Transient Receptor Potential Channels and Metabolism." dans: Molecules and cells, Vol. 42, Issue 8, pp. 569-578, (2020) (PubMed).

Kaupp, Seifert: "Cyclic nucleotide-gated ion channels." dans: Physiological reviews, Vol. 82, Issue 3, pp. 769-824, (2002) (PubMed).

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