Ion Channels

Ion channels are pore-forming proteins that allow the flow of ions across membranes, either plasma membranes or the membranes of intracellular organelles. Many ion channels (such as most Na, K Ca and some Cl channels) are gated by voltage but others (such as certain K and Cl channels, TRP channels, ryanodine receptors and IP3 receptors) are relatively voltage-insensitive and are gated by second messengers and other intracellular and/or extracellular mediators.(1)

Most ion channels are highly selective for the class of ions crossing the channel. They can therefore be easily classified into sodium channels, calcium channels, potassium channels, proton channels or non-selective cation channels. Research on ion channels requires a large number of methods and materials. We offer monoclonal and polyclonal antibodies, ELISA kits and high-quality made-to-order proteins for this complex topic.

Aquaporins

Aquaporins (often called aquaporin water channels) are a family of small, integral membrane proteins that are expressed broadly throughout the animal and plant kingdoms. They have a similar basic structure, with aquaporin monomers consisting of six transmembrane helical segments and two short helical segments that surround cytoplasmic and extracellular vestibules connected by a narrow aqueous pore.(2)

To search our Aquaporin antibodies, kits, proteins click on the links below.

Calcium Channels

A calcium channel is a transmembrane ion channel that is permeable to calcium ions. The permeability is controlled either by voltage-gated calcium channels or ligand-gated calcium channels. We offer some hand-picked monoclonal and polyclonal antibodies for research on calcium channels.

Produit Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-Cav1.2 Ca2+ Channel (AA 1507-1733), (C-Term) antibody Human, Mouse (Murine), Rat (Rattus) Monoclonal ICC, IF, IP, IHC, WB ABIN1721482 100 μg element-ABIN1721482
anti-Cav1.3 Ca+2 Channel (AA 2025-2161), (C-Term) antibody Human, Mouse (Murine), Rabbit, Rat (Rattus) Monoclonal ICC, FACS, IF, IP, IHC, WB ABIN1721483 100 μg element-ABIN1721483
anti-Cav3.1 Ca2+ Channel (AA 2052-2172), (C-Term), (Cytoplasmic) antibody Human, Mouse (Murine), Rat (Rattus) Monoclonal IHC, WB ABIN1098196 100 μg element-ABIN1098196
anti-Cavbeta1 (N-Term) antibody Rat (Rattus) Monoclonal FM, IHC, IP, WB ABIN6658066 100 μg element-ABIN6658066
anti-Cavbeta1 antibody Mammalian Monoclonal ISt, IHC, WB ABIN1304586 5 mL element-ABIN1304586
anti-Cavbeta2 Ca+2 Channel (AA 189-205) antibody Human, Mouse (Murine), Rat (Rattus) Monoclonal ICC, IF, IHC, WB ABIN1721488 100 μg element-ABIN1721488
anti-Cavbeta4 (C-Term) antibody Human, Mouse (Murine) Polyclonal ICC, IF, IHC (p), WB ABIN2854649 100 μL element-ABIN2854649
anti-Cavbeta4 antibody Mammalian Monoclonal ISt, IHC, WB ABIN1304590 5 mL element-ABIN1304590

See all Calcium Channel Antibodies

Potassium Channels

Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting other ions.(3)

Produit Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-BK Channel BETA2 (C-Term), (N-Term) antibody Mouse (Murine) Monoclonal IHC, IP, WB ABIN6657685 100 μg element-ABIN6657685
anti-BK Channel BETA3 (N-Term) antibody Mouse (Murine) Monoclonal FM, IHC, IP, WB ABIN6657686 100 μg element-ABIN6657686
anti-KCNQ1 K+ Channel antibody Human, Mouse (Murine), Rat (Rattus) Monoclonal ICC, FACS, IF, IP, IHC, WB ABIN1721589 100 μg element-ABIN1721589
anti-KCNQ2 K+ Channel (AA 1-59) antibody Human, Mouse (Murine), Rat (Rattus) Monoclonal ICC, FACS, IF, IP, IHC, WB ABIN1721590 100 μg element-ABIN1721590
anti-Potassium Channel, Subfamily K, Member 3 (KCNK3) (C-Term) antibody Cow (Bovine), Dog (Canine), Guinea Pig, Human, Mouse (Murine), Rabbit, Rat (Rattus), Sheep (Ovine) Polyclonal WB ABIN2776142 100 μL element-ABIN2776142
anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) antibody Human Monoclonal FACS, ELISA, WB ABIN969227 100 μL element-ABIN969227
anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) (AA 1-59) antibody (FITC) Hamster, Human, Mouse (Murine), Rat (Rattus) Monoclonal AA, ICC, IF, IHC, IP, WB ABIN2482775 100 μg element-ABIN2482775
anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 3 (KCNQ3) (C-Term) antibody Human, Mouse (Murine), Rat (Rattus), Pig (Porcine) Polyclonal ELISA ABIN570733 100 μg element-ABIN570733
anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) (C-Term) antibody Human, Mouse (Murine) Polyclonal ELISA, WB ABIN3185286 100 μL element-ABIN3185286

Sodium Channels

There are two major classes of sodium channels in mammals: The voltage-gated sodium channel (VGSC) family and the epithelial sodium channel (ESC). Voltage-gated sodium channels exist throughout the body in various cell types, while epithelial sodium channels are located primarily in the skin and kidney.(4)

Produit Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) antibody Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus) Polyclonal WB ABIN2776229 100 μL element-ABIN2776229
anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 629-650) antibody Hamster, Human, Mouse (Murine), Rat (Rattus), Xenopus laevis Polyclonal ICC, IF, IHC, WB ABIN863204 100 μg element-ABIN863204
anti-Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B) (AA 600-640), (pSer633) antibody Human, Mouse (Murine), Rat (Rattus) Polyclonal IF (p), IHC (p), WB ABIN713471 100 μL element-ABIN713471
anti-Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) (AA 629-650) antibody (FITC) Hamster, Human, Mouse (Murine), Rat (Rattus), Xenopus laevis Polyclonal ICC, IF, IHC, WB ABIN2486428 100 μg element-ABIN2486428
anti-Sodium Channel, Voltage-Gated, Type VII, alpha Subunit (SCN7A) (AA 2272-2371) antibody Human Polyclonal ELISA, WB ABIN565642 50 μL element-ABIN565642
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (FITC) Human, Mouse (Murine), Rat (Rattus) Monoclonal ICC, IF, WB ABIN2483030 100 μg element-ABIN2483030

TRP

Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.(5)

Produit Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) (AA 500-540), (Extracellular Loop) antibody Rat (Rattus), Mouse (Murine), Human Polyclonal IHC, WB ABIN351117 100 μL element-ABIN351117
anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5) (AA 827-845) antibody (FITC) Human, Mouse (Murine), Rat (Rattus) Monoclonal AA, IHC, IP, WB ABIN2485379 100 μg element-ABIN2485379
anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (C-Term) antibody Human, Chimpanzee Monoclonal IHC, ELISA, WB ABIN964697 100 μg element-ABIN964697
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) antibody Dog (Canine), Human, Monkey Monoclonal IHC, WB ABIN2725815 0.1 mL element-ABIN2725815
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (Middle Region) antibody Human Polyclonal EIA, IHC (p), WB ABIN4620541 0.1 mg element-ABIN4620541

See all TRP-related Antibodies

Cyclic Nucleotide-gated Ion Channels

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels.(6) Below you will find a selection of polyclonal antibodies against CNG ion channels.

Produit Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (C-Term) antibody Human Polyclonal ICC, IF, IHC (p), WB ABIN2856869 100 μL element-ABIN2856869
anti-Cyclic Nucleotide Gated Channel alpha 3 (CNGA3) antibody Human Polyclonal WB ABIN1679299 100 μg element-ABIN1679299
anti-Cyclic Nucleotide Gated Channel alpha 4 (CNGA4) (AA 131-160), (N-Term) antibody Mouse (Murine) Polyclonal IHC (p), WB ABIN5532896 400 μL element-ABIN5532896
anti-Cyclic Nucleotide Gated Channel beta 1 (CNGB1) (Center) antibody Human Polyclonal WB ABIN5619308 100 μL element-ABIN5619308

See all CNG ion channel Antibodies

Hyperpolarization-activated Cyclic Nucleotide-gated Channels (HCN)

A hyperpolarization-activated cyclic nucleotide-gated channel (HCN) is a subtype of CNG channel that is gated by hyperpolarization of the cell membrane. There are four HCN channels HCN1, HCN2, HCN3, and HCN4.

Produit Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (HRP) Human, Mouse (Murine), Rat (Rattus) Monoclonal AA, IHC, IP, WB ABIN2483966 100 μg element-ABIN2483966
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (C-Term) antibody Rat (Rattus) Monoclonal FM, IHC, IP, WB ABIN6658118 100 μg element-ABIN6658118
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 3 (HCN3) (AA 660-779) antibody (HRP) Human, Mouse (Murine), Rat (Rattus) Monoclonal AA, ICC, IF, IHC, WB ABIN2483847 100 μg element-ABIN2483847
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) antibody Human, Mouse (Murine), Rat (Rattus) Polyclonal IF (p), IHC (p), WB ABIN733043 100 μL element-ABIN733043

See all HCN ion channel Antibodies

We offer you Made-to-order Channel Proteins

We offer high-purity made-to-order ion channel proteins with native state folding guarantee. Below you will find a selection of potassium channel proteins. Please contact us via email, chat, or phone for more information about our made-to-order proteins.

Produit Protein Type Conjugate Cat. No. Quantity Relevance ProductGrid: uniqueid
Cyclic Nucleotide Gated Channel alpha 1 (CNGA1) (AA 1-164) protein (His tag) Recombinant His tag ABIN3077909 1 mg element-ABIN3077909
Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 1-146) protein (His tag) Recombinant His tag ABIN3081371 1 mg element-ABIN3081371
Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1) (AA 389-1236) protein (His tag) Recombinant His tag ABIN3093393 1 mg element-ABIN3093393
Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) (AA 1-872) protein (rho-1D4 tag) Recombinant rho-1D4 tag ABIN3093343 0.5 mg element-ABIN3093343
Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5) (AA 1-330) protein (His tag) Recombinant His tag ABIN3130433 1 mg element-ABIN3130433

References:

(1) Ion Channels. Br J Pharmacol. 2011 Nov;164(Suppl 1):S137–S174. doi: 10.1111/j.1476-5381.2011.01649_5.x. PMCID: PMC3315630.

(2) Verkman AS. Aquaporins. Curr Biol. 2013 Jan 21;23(2):R52-5. doi: 10.1016/j.cub.2012.11.025. PMID: 23347934; PMCID: PMC3590904.

(3) Kuang Q, Purhonen P, Hebert H. Structure of potassium channels. Cell Mol Life Sci. 2015 Oct;72(19):3677-93. doi: 10.1007/s00018-015-1948-5. Epub 2015 Jun 13. PMID: 26070303; PMCID: PMC4565861.

(4) Hernandez CM, Richards JR. Physiology, Sodium Channels. [Updated 2019 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545257/

(5) Dhakal S, Lee Y. Transient Receptor Potential Channels and Metabolism. Mol Cells. 2019 Aug 31;42(8):569-578. doi: 10.14348/molcells.2019.0007. PMID: 31446746; PMCID: PMC6715338.

(6) Kaupp UB, Seifert R. Cyclic nucleotide-gated ion channels. Physiol Rev. 2002 Jul;82(3):769-824.