Recombinant MAP2 anticorps (pSer136)

N° du produit ABIN7879708

Cet anticorps anti-MAP2 Monoclonal Lapin (Clone 32M37) (ABIN7879708) détecte spécifiquement MAP2 dans WB, IHC, ICC et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant MAP2 anticorps (pSer136) (ABIN7879708)

Antigène: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MAP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 32M37

Détail du produit anti-MAP2 anticorps

Épitope: pSer136

Fonction: Phospho-MAP2 (Ser136) Antibody / Microtubule-associated protein 2

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Phospho-MAP2 (S136) was used as the immunogen for the Phospho-MAP2 (Ser136) antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Phospho-MAP2 (Ser136) antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the Phospho-MAP2 (Ser136) antibody at -20oC.

Détails sur MAP2

Antigène: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Autre désignation: MAP2

Sujet: Phospho-MAP2 (Ser136) antibody detects microtubule-associated protein 2 (MAP2) when phosphorylated at serine 136. MAP2 is a neuronal cytoskeletal protein that stabilizes microtubules and contributes to dendritic architecture, synaptic plasticity, and neuronal signaling. Phosphorylation at Ser136, mediated by kinases such as PKA and CaMKII, modulates MAP2's ability to bind microtubules and regulate cytoskeletal dynamics.

Research using Phospho-MAP2 (Ser136) antibody has demonstrated its importance in neuronal development and function. Phosphorylation at Ser136 reduces MAP2's affinity for microtubules, promoting reorganization of dendritic structures. This regulation is critical during synaptogenesis, axon guidance, and activity-dependent plasticity. In models of learning and memory, changes in Ser136 phosphorylation correlate with synaptic remodeling and behavioral adaptation.

In neurodegenerative disease, dysregulated MAP2 phosphorylation contributes to cytoskeletal instability and neuronal dysfunction. Aberrant phosphorylation patterns are observed in Alzheimer's disease, Parkinson's disease, and traumatic brain injury, where MAP2 loss or mislocalization signals neuronal damage. Monitoring Ser136 phosphorylation provides insights into neuronal health and disease progression.

MAP2 phosphorylation also influences interactions with signaling molecules and cytoskeletal regulators. By modulating dendritic morphology, phospho-MAP2 contributes to long-term potentiation and depression, essential processes underlying cognition. Altered Ser136 phosphorylation has been linked to psychiatric conditions, including schizophrenia and depression, where synaptic dysfunction is a hallmark.

Antibodies against phospho-MAP2 (Ser136) are validated for immunohistochemistry, immunofluorescence, and western blot. These reagents selectively detect the phosphorylated form, distinguishing it from total MAP2. Clone-based antibodies ensure reproducibility and specificity in complex neuronal systems.

NSJ Bioreagents supplies this Phospho-MAP2 (Ser136) antibody for studies in neurodevelopment, synaptic plasticity, and neurodegenerative disease.

UniProt: P11137