TBXA2R anticorps (3rd Intracellular Loop)

N° du produit ABIN7885574

Cet anticorps anti-TBXA2R Polyclonal Lapin (ABIN7885574) détecte spécifiquement TBXA2R dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TBXA2R anticorps (3rd Intracellular Loop) (ABIN7885574)

Antigène: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBXA2R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-TBXA2R anticorps

Épitope: 3rd Intracellular Loop, AA 225-239

Fonction: A Rabbit Polyclonal Antibody to Thromboxane A2 Receptor

Homologie: Rat - 14,15 amino acid residues identical, human - 12, mouse - 13

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HAREATQRPRD(S)EVE, corresponding to amino acid residues 225-239 of rat TBXA2R

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237385)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TBXA2R

Antigène: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Autre désignation: Prostanoid TP receptor

Sujet:

Synonyms: Prostanoid TP receptor, TXA2-R, TBXA2R

Description: Thromboxane A2 (TxA2) is a prostanoid that is synthesized from arachidonic acid and plays an important role in haemostasis, a process regulating platelet aggregation and vascular tone. Thromboxane A2 binds to the thromboxane A2 receptor (TBXA2R) to induce strong vasoconstriction in renal arteries.Thromboxane A2 receptor is a seven-transmembrane G-protein coupled receptor localized on the cell membrane and in intracellular compartments. TBXA2R is expressed in the central nervous system in several types of cells, such as microglia, oligodendrocytes and astrocytes. Imbalances in the levels of the receptor is widely implicated in several cardiovascular, pulmonary, renal and prostate pathologies1-3.Thromboxane A2 receptor mediates vasoconstriction and ischemia and its activation is implicated in atherosclerosis and inflammation. Activation of the receptor induces endothelial cell apoptosis by inhibiting Akt phosphorylation and also inhibits endothelial cell migration and angiogenesis by decreasing Akt and eNOS phosphorylation1-3.

ID gène: 24816

UniProt: P34978