TBXA2R anticorps (Extracellular, N-Term)

N° du produit ABIN7885575

Cet anticorps Lapin Polyclonal détecte spécifiquement TBXA2R dans WB, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TBXA2R anticorps (Extracellular, N-Term) (ABIN7885575)

Antigène: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBXA2R est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-TBXA2R anticorps

Épitope: AA 13-27, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to Thromboxane A2 Receptor (extracellular).

Homologie: Mouse,rat - 12 out of 15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RPTNITLEERRLIAS, corresponding to amino acid residues 13 - 27 of human TBXA2R 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237389)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TBXA2R

Antigène: TBXA2R (Thromboxane A2 Receptor (TBXA2R))

Autre désignation: Prostanoid TP receptor

Sujet:

Synonyms: Prostanoid TP receptor, TXA2-R, TBXA2R

Description: Thromboxane A2 (TxA2) is a prostanoid that is synthesized from arachidonic acid and plays an important role in haemostasis, a process regulating platelet aggregation and vascular tone. Thromboxane A2 binds to the thromboxane A2 receptor (TBXA2R) to induce strong vasoconstriction in renal arteries.Thromboxane A2 receptor is a seven-transmembrane G-protein coupled receptor localized on the cell membrane and in intracellular compartments. TBXA2R is expressed in the central nervous system in several types of cells, such as microglia, oligodendrocytes and astrocytes. Imbalances in the levels of the receptor is widely implicated in several cardiovascular, pulmonary, renal and prostate pathologies1-3.Thromboxane A2 receptor mediates vasoconstriction and ischemia and its activation is implicated in atherosclerosis and inflammation. Activation of the receptor induces endothelial cell apoptosis by inhibiting Akt phosphorylation and also inhibits endothelial cell migration and angiogenesis by decreasing Akt and eNOS phosphorylation1-3.

ID gène: 6915

UniProt: P21731