HDC anticorps (AA 12-662) (Fluoro488)

N° du produit ABIN7997653

L’anticorps anti-HDC Polyclonal Lapin est utilisé pour la détection de HDC dans des échantillons de Humain et Souris. Il a été validé pour FACS.

Aperçu rapide pour HDC anticorps (AA 12-662) (Fluoro488) (ABIN7997653)

Antigène: HDC (Histidine Decarboxylase (HDC))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDC est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-HDC anticorps (Fluoro488)

Épitope: AA 12-662

Fonction: Anti-Histidine decarboxylase/HDC Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Histidine decarboxylase/HDC recombinant protein (Position: R12-V662).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur HDC

Antigène: HDC (Histidine Decarboxylase (HDC))

Autre désignation: HDC

Sujet:

Background: HDC(Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.

Gene Full Name: histidine decarboxylase

ID gène: 3067

UniProt: P19113