APOBEC3A anticorps (C-Term)

N° du produit ABIN8094802

Cet anticorps Lapin Polyclonal détecte spécifiquement APOBEC3A dans WB. Il présente une réactivité avec des échantillons de Humain et Porc.

Aperçu rapide pour APOBEC3A anticorps (C-Term) (ABIN8094802)

Antigène: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Reactivité: Humain, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APOBEC3A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-APOBEC3A anticorps

Épitope: C-Term

Fonction: APOBEC3A Antibody - C-terminal region

Séquence: AQVSIMTYDE FKHCWDTFVD HQGCPFQPWD GLDEHSQALS GRLRAILQNQ

Homologie: Human: 100%, Pig: 100%

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ABC3A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP61579-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur APOBEC3A

Antigène: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Autre désignation: APOBEC3A

Sujet:

Background Information: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.

Gene Name: APOBEC3A and APOBEC3B deletion hybrid

Alternative Symbols: A3A, APOBEC3A

Protein Name: probable DNA dC->dU-editing enzyme APOBEC-3A

Poids moléculaire: 21kDa

ID gène: 100913187

NCBI Accession: XP_005277017

UniProt: P31941