KPNA2 anticorps (AA 254-497)
(3 références)Aperçu rapide pour KPNA2 anticorps (AA 254-497) (ABIN967998)
Antigène
Voir toutes KPNA2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
-
-
Épitope
- AA 254-497
-
Réactivité croisée
- Souris, Rat (Rattus), Chien, Mouche des fruits (Drosophila melanogaster)
-
Attributs du produit
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
-
Immunogène
- Human Rch-1 aa. 254-497
-
Isotype
- IgG1
-
-
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (AA 1-530) antibody
KPNA2 Reactivité: Humain, Souris WB, IHC, ELISA, ICC, FACS Hôte: Souris Monoclonal 1E8B7 unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (AA 51-529) antibodyKPNA2 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, FACS Hôte: Lapin Polyclonal unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (AA 157-412) antibodyKPNA2 Reactivité: Humain WB, IHC, ICC, IF, FACS Hôte: Lapin Polyclonal unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (C-Term) antibodyVerified KPNA2 Reactivité: Humain, Rat WB, IHC, ELISA, IF, FACS Hôte: Chèvre Polyclonal unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (AA 2-285) antibodyKPNA2 Reactivité: Humain WB, IHC, ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (AA 1-290) antibodyKPNA2 Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (C-Term) antibodyKPNA2 Reactivité: Humain WB, ICC, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (AA 157-412) antibodyKPNA2 Reactivité: Humain WB, ICC, IF, FACS Hôte: Souris Monoclonal C10 unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) antibodyKPNA2 Reactivité: Humain, Souris, Rat WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) (AA 1-529) antibodyKPNA2 Reactivité: Humain WB Hôte: Souris Polyclonal unconjugated
-
-
Commentaires
-
Related Products: ABIN968535, ABIN967389
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Concentration
- 250 μg/mL
-
Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
-
Agent conservateur
- Sodium azide
-
Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Stock
- -20 °C
-
Stockage commentaire
- Store undiluted at -20° C.
-
-
-
: "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 14, pp. 7835-40, (2000) (PubMed).
: "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 14, pp. 6532-6, (1995) (PubMed).
: "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences." dans: Science (New York, N.Y.), Vol. 268, Issue 5213, pp. 1049-53, (1995) (PubMed).
-
-
- KPNA2 (Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))
-
Autre désignation
- Karyopherin alpha 2
-
Sujet
-
The two step process of importing proteins into the nucleus involves the binding and interaction of several cytosolic and nuclear pore proteins. Proteins to be translocated into the nucleus contain a nuclear localization sequence (NLS) which is recognized and bound by carrier proteins in the cytosol. Heterodimers belonging to a highly conserved family of proteins called karyopherins are required for successful nuclear localization of cytosolic proteins. The alpha-subunits appear to function in the binding of NLS (both simple and bitartite NLS motifs), but both alpha- and beta-subunits are required for successful docking to the nuclear envelope. ATP is required for complete translocation of proteins into the nucleus. Karyopherin alpha2 was first identified as Rch-1, an NLS receptor which interacts with the RAG-1 recombination-activating protein in developing B and T cells. Rch-1 has been reported to be 44% identical to karyopherin alpha1 (hSRP-1 /NPI-1). This antibody is routinely tested by western blot analysis.
Synonyms: Rch-1 -
Poids moléculaire
- 58 kDa
-
Pathways
- M Phase, Protein targeting to Nucleus
Antigène
-
