VDAC1 anticorps (C-Term)
Aperçu rapide pour VDAC1 anticorps (C-Term) (ABIN183134)
Antigène
Voir toutes VDAC1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- C-Term
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Séquence
- SAKVNNSSLI GLGYTQTLKP GIKLTLSALL DGKNVNAGGH KLGLGLEFQA
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Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%
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Attributs du produit
- This is a rabbit polyclonal antibody against VDAC1. It was validated on Western Blot and immunohistochemistry.
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Purification
- Protein A purified
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Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human VDAC1
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Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
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Commentaires
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Antigen size: 283 AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes." dans: PLoS ONE, Vol. 8, Issue 6, pp. e66478, (2013) (PubMed).
: "Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic." dans: Human molecular genetics, Vol. 21, Issue 21, pp. 4680-702, (2012) (PubMed).
: "Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins." dans: Journal of proteome research, Vol. 8, Issue 11, pp. 5196-211, (2009) (PubMed).
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- VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))
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Autre désignation
- VDAC1
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Sujet
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The voltage-dependent anion-selective channel 1 (VDAC1) functions as a channel in membranous structures for the outer mitochondrial membrane, the cell membrane, endosomes, caveolae, the sarcoplasmatic reticulum, synaptosomes, and post-synaptic density fraction. A major function of VDAC1 in the plasma membrane is that of a NADH(-ferricyanide) reductase that may be involved in the maintenance of cellular redox homeostasis.
Alias Symbols: PORIN, VDAC-1
Protein Interaction Partner: UBC, KLHL40, SPRTN, MDM2, ADRB2, ASB14, ASB17, PARK2, BAG3, env, VCAM1, HK1, ATF2, FMNL1, TUBA1B, MDC1, CAV1, Htt, SFXN3, SUGP1, UBAP2, UFM1, ACAD9, MGAT4B, ACAA2, ZMPSTE24, VAPA, ALDH5A1, SF1, VDAC3, VDAC2, UBA52, TIAL1, FLOT2, CDK2, SIRT7, SUMO4, MAPK3,
Protein Size: 283 -
Poids moléculaire
- 31 kDa
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ID gène
- 7416
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NCBI Accession
- NM_003374, NP_003365
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UniProt
- Q5FVE7
Antigène
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