BACH1 anticorps
Aperçu rapide pour BACH1 anticorps (ABIN272133)
Antigène
Voir toutes BACH1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody detects endogenous levels of BACH1 protein. (region surrounding Leu160)
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Réactivité croisée (Details)
- Species reactivity (tested):Human.
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Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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Pureté
- > 95 % pure by SDS-PAGE
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anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 396-492) antibody
BACH1 Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 1B8 unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (Internal Region) antibodyBACH1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) antibodyBACH1 Reactivité: Humain WB, IHC, IHC (p), FACS Hôte: Souris Monoclonal 4E11 unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 1-320) antibodyBACH1 Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 1-320) antibodyBACH1 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (Center) antibodyBACH1 Reactivité: Humain, Singe WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 250-263) antibodyVerified BACH1 Reactivité: Humain WB, ELISA Hôte: Chèvre Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 134-421) antibodyBACH1 Reactivité: Humain WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (C-Term) antibodyBACH1 Reactivité: Humain, Lapin WB Hôte: Lapin Polyclonal unconjugated
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) antibodyBACH1 Reactivité: Humain WB Hôte: Souris Monoclonal 25GB8110 unconjugated
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Indications d'application
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ELISA: 1: 20000approx. 140000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1,0 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- DO NOT FREEZE!
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Stock
- 4 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C.
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- BACH1 (BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1))
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Autre désignation
- BACH1
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Sujet
- Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors. They dimerize with other proteins and bind DNA to either represse or activate transcription depending on the dimer compositions. BACH1 and BACH2, heterodimerization partners of MafK, are members of a novel family of BTB/POZ-basic region leucine zipper (bzip) factors. BACH1 and BACH2 have significant similarity to each other in BTB domain and Cap'n' collar-type bZip domain but are otherwise divergent. BACH1 appears ubiquitous, whereas BACH2 is restricted to monocytes, neuronal cells and is abundantly expressed in the early stages of B-cell differentiation. BACH2, a 841 amino acid polypeptide, is an Nrf2-related transcription repressor and a tissue-specific partner of the Maf oncoprotein family. In culture cells, BACH2 is localized to the cytoplasm through its C-terminal cytoplasmic localization signal (CLS). Oxidative stressors aborted the CLS activity and induce nuclear accumulation of BACH2, which mediates nucleocytoplasmic communciation to couple oxidative stress and transcription repression in mammalian cells. BACH2 heterodimerizes with MAZR through its BTB/POZ domain to activate transcription. BACH2 also plays an important role in the regulation of B cell development.Synonyms: BTB and CNC homolog 1, HA2303, Transcription regulator protein BACH1, basic leucine zipper transcription factor 1
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Poids moléculaire
- approx. 83 kDa
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ID gène
- 571
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NCBI Accession
- NP_001177
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UniProt
- O14867
Antigène
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