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NFKB2 anticorps (Middle Region)

Cet anticorps Lapin Polyclonal détecte spécifiquement NFKB2 dans IHC. Il présente une réactivité avec des échantillons de Humain. Il a été cité dans 7+ publications.
N° du produit ABIN966670
603,63 €
Plus frais de livraison 40,00 € et TVA
0.1 mg
Destination: France
Envoi sous 8 à 12 jours ouvrables

Aperçu rapide pour NFKB2 anticorps (Middle Region) (ABIN966670)

Antigène

Voir toutes NFKB2 Anticorps
NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

Reactivité

  • 144
  • 106
  • 71
  • 9
  • 7
  • 6
  • 6
  • 5
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Humain

Hôte

  • 146
  • 7
Lapin

Clonalité

  • 114
  • 38
  • 1
Polyclonal

Conjugué

  • 87
  • 10
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Cet anticorp NFKB2 est non-conjugé

Application

  • 104
  • 51
  • 50
  • 44
  • 41
  • 33
  • 15
  • 13
  • 13
  • 11
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (IHC)
  • Épitope

    • 16
    • 10
    • 9
    • 9
    • 8
    • 7
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Immunogène

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to middle amino acid residues of human NFKB2 (Nuclear factor NF-kappa-B p100 subunit)
  • Restrictions

    For Research Use only
  • Stock

    4 °C
  • Li, Nabel: "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." dans: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, (1997) (PubMed).

    Dobrzanski, Ryseck, Bravo: "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." dans: The EMBO journal, Vol. 13, Issue 19, pp. 4608-16, (1994) (PubMed).

    Beg, Baldwin: "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor." dans: Oncogene, Vol. 9, Issue 5, pp. 1487-92, (1994) (PubMed).

    Potter, Larson, Eckes, Schmid, Nabel, Verdine, Sharp: "Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene." dans: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18882-90, (1993) (PubMed).

    Bours, Franzoso, Azarenko, Park, Kanno, Brown, Siebenlist: "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers." dans: Cell, Vol. 72, Issue 5, pp. 729-39, (1993) (PubMed).

    Bours, Burd, Brown, Villalobos, Park, Ryseck, Bravo, Kelly, Siebenlist: "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site." dans: Molecular and cellular biology, Vol. 12, Issue 2, pp. 685-95, (1992) (PubMed).

    Schmid, Perkins, Duckett, Andrews, Nabel: "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65." dans: Nature, Vol. 352, Issue 6337, pp. 733-6, (1991) (PubMed).

  • Antigène

    NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

    Autre désignation

    NFKB2

    Sujet

    NFKB2 (Nuclear factor NF-kappa-B p100 subunit) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function.
    Synonyms: LYT10(Lymphocyte translocation chromosome 10)

    Pathways

    Toll-Like Receptors Cascades
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