SCNN1D anticorps
Aperçu rapide pour SCNN1D anticorps (ABIN317816)
Antigène
Voir toutes SCNN1D AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody detects endogenous levels of ENaCδ protein. (region surrounding Pro446)
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Réactivité croisée (Details)
- Species reactivity (tested):Human.
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Purification
- Affinity chromatography
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anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (C-Term) antibody
SCNN1D Reactivité: Humain WB, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (AA 161-189), (N-Term) antibodySCNN1D Reactivité: Humain WB Hôte: Lapin Polyclonal RB37553 unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (AA 1-638) antibodySCNN1D Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (C-Term) antibodyVerified SCNN1D Reactivité: Humain ELISA, IHC Hôte: Chèvre Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) antibodySCNN1D Reactivité: Rat, Souris WB Hôte: Lapin Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (AA 292-519) antibodySCNN1D Reactivité: Humain ELISA, IF Hôte: Lapin Polyclonal unconjugated
anti-Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (AA 411-460) antibodySCNN1D Reactivité: Humain WB, ELISA, IF Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1,0 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- SCNN1D (Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D))
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Autre désignation
- ENAC delta / SCNN1D
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Sujet
- The epithelial sodium channel (ENaC) is a member of the ENaC/DEG superfamily that is located on the apical surface of cells. ENaC mediates sodium reabsorption in kidney, distal colon, lung, ducts of exocrine glands and other organs. ENaC is formed by heteromultimerization of four homologous subunits, α, β, γ and δ. The most frequently formed heterotetramer consists of 2α, 1β, and 1γ subunit, but the α subunit can be replaced by a δ subunit. The αENaC gene maps to human chromosome 12p13, and expresses a glycosylated protein. Both the β and γENaC genes map to human chromosome 16p12, and the γENaC transcript is detected as a glycosylated protein. The carboxy-terminus of all ENaC subunits contains PY motifs, which interact with the ubiquitin protein ligase, Nedd4, to regulate intracellular sodium concentrations. Gain-of-function mutations involving the PY motif cause Liddle's syndrome, an autosomal dominant form of hypertension, resulting from excessive renal sodium absorption. Conversely, ENaC loss-of-function mutations result in pseudohypoaldosteronism type I, a disorder characterized by salt wasting and hypotension.Synonyms: Amiloride-sensitive sodium channel subunit delta, DNACH, Delta-ENaC, Delta-NaCH, ENaCD, Epithelial Na(+) channel subunit delta, Nonvoltage-gated sodium channel 1 subunit delta, SCNED
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Poids moléculaire
- approx. 80 kDa
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ID gène
- 6339
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NCBI Accession
- NP_001123885
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UniProt
- P51172
Antigène
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